Q91V12: Cytosolic acyl coenzyme A thioester hydrolase

General Information

Protein names	- Cytosolic acyl coenzyme A thioester hydrolase - 3.1.2.2 {ECO:0000250\|UniProtKB:Q64559} - Acyl-CoA thioesterase 7 - Brain acyl-CoA hydrolase - BACH - CTE-IIa - CTE-II - Long chain acyl-CoA thioester hydrolase
Gene names	Acot7
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q91V12

5 N-termini

4 C-termini

3 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform A of Cytosolic acyl coenzyme A thioester hydrolase - Isoform C of Cytosolic acyl coenzyme A thioester hydrolase - Isoform D of Cytosolic acyl coenzyme A thioester hydrolase

Sequence View

        10         20         30         40         50         60
MKLLVGTLRL WEVGRQVAFS SLTPGQECSG LRKTFWAAMR AVRTRADHQK LGHCVTMGRI
        70         80         90        100        110        120
MRPDDANVAG NVHGGTILKM IEEAGAIIST RHCNSQNGER CVAALARVER TDFLSPMCIG
       130        140        150        160        170        180
EVAHVSAEIT YTSKHSVEVQ VHVMSENILT GTKKLTNKAT LWYVPLSLKN VDKVLEVPPI
       190        200        210        220        230        240
VYLRQEQEEE GRKRYEAQKL ERMETKWRNG DIVQPVLNPE PNTVSYSQSS LIHLVGPSDC
       250        260        270        280        290        300
TLHGFVHGGV TMKLMDEVAG IVAARHCKTN IVTASVDAIN FHDKIRKGCV ITISGRMTFT
       310        320        330        340        350        360
SNKSMEIEVL VDADPVVDNS QKRYRAASAF FTYVSLNQEG KPMPVPQLVP ETEDEKKRFE
       370        380
EGKGRYLQMK AKRQGHTEPQ P         10         20         30         40         50         60
MKLLVGTLRL WEVGRQVAFS SLTPGQECSG LRKTFWAAMR AVRTRADHQK LGHCVTMGRI
        70         80         90        100        110        120
MRPDDANVAG NVHGGTILKM IEEAGAIIST RHCNSQNGER CVAALARVER TDFLSPMCIG
       130        140        150        160        170        180
EVAHVSAEIT YTSKHSVEVQ VHVMSENILT GTKKLTNKAT LWYVPLSLKN VDKVLEVPPI
       190        200        210        220        230        240
VYLRQEQEEE GRKRYEAQKL ERMETKWRNG DIVQPVLNPE PNTVSYSQSS LIHLVGPSDC
       250        260        270        280        290        300
TLHGFVHGGV TMKLMDEVAG IVAARHCKTN IVTASVDAIN FHDKIRKGCV ITISGRMTFT
       310        320        330        340        350        360
SNKSMEIEVL VDADPVVDNS QKRYRAASAF FTYVSLNQEG KPMPVPQLVP ETEDEKKRFE
       370        380
EGKGRYLQMK AKRQGHTEPQ P         10         20         30         40         50         60
MKLLVGTLRL WEVGRQVAFS SLTPGQECSG LRKTFWAAMR AVRTRADHQK LGHCVTMGRI
        70         80         90        100        110        120
MRPDDANVAG NVHGGTILKM IEEAGAIIST RHCNSQNGER CVAALARVER TDFLSPMCIG
       130        140        150        160        170        180
EVAHVSAEIT YTSKHSVEVQ VHVMSENILT GTKKLTNKAT LWYVPLSLKN VDKVLEVPPI
       190        200        210        220        230        240
VYLRQEQEEE GRKRYEAQKL ERMETKWRNG DIVQPVLNPE PNTVSYSQSS LIHLVGPSDC
       250        260        270        280        290        300
TLHGFVHGGV TMKLMDEVAG IVAARHCKTN IVTASVDAIN FHDKIRKGCV ITISGRMTFT
       310        320        330        340        350        360
SNKSMEIEVL VDADPVVDNS QKRYRAASAF FTYVSLNQEG KPMPVPQLVP ETEDEKKRFE
       370        380
EGKGRYLQMK AKRQGHTEPQ P

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q91V12-1-unknown	MKLLVG...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q91V12-81-unknown	IEEAGA...	81	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30876
Q91V12-81-unknown	IEEAGA...	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138193
Q91V12-81-unknown	IEEAGA...	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt139192
Q91V12-81-unknown	IEEAGA...	81	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt141256
Q91V12-115-unknown	SPMCIG...	115	inferred from electronic annotation	unknown	TISdb	inferred from TISdb
Q91V12-115-unknown	SPMCIG...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197160
Q91V12-115-unknown	SPMCIG...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197159
Q91V12-115-unknown	SPMCIG...	115	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt197158
Q91V12-255-unknown	MDEVAG...	255	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30880
Q91V12-255-unknown	MDEVAG...	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147062
Q91V12-255-unknown	MDEVAG...	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt147526
Q91V12-255-unknown	MDEVAG...	255	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt148543
Q91V12-367-unknown	LQMKAK...	367	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30884
Q91V12-367-unknown	LQMKAK...	367	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150417
Q91V12-367-unknown	LQMKAK...	367	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150643
Q91V12-367-unknown	LQMKAK...	367	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt151306

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...TILKMI	80	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30876
...TILKMI	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121222
...TILKMI	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt122267
...TILKMI	80	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124419
...VTMKLM	254	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30880
...VTMKLM	254	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130395
...VTMKLM	254	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt130876
...VTMKLM	254	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt131917
...GKGRYL	366	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30884
...GKGRYL	366	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt133813
...GKGRYL	366	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134041
...GKGRYL	366	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt134708
...TEPQP	381	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...TEPQP	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63776
...TEPQP	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63777
...TEPQP	381	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt63778

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Evidence name
CATE_MOUSE	80	LKMI.\|.IEEA	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> BACH_MOUSE @80
CATE_MOUSE	254	MKLM.\|.MDEV	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> BACH_MOUSE @254
CATE_MOUSE	366	GRYL.\|.LQMK	inferred from experiment	unknown	MEROPS	Merops CATE_MOUSE -> BACH_MOUSE @366

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)