TopFIND 4.0

Q91VA3: Calpain-8

General Information

Protein names
- Calpain-8
- 3.4.22.53
- New calpain 2
- nCL-2
- Stomach-specific M-type calpain
Gene names Capn8
Organism Mus musculus
Protease Family C02.007
Protease ID C02.007
Chromosome location
UniProt ID Q91VA3

2

N-termini

2

C-termini

1

Cleavages

1

Substrates

Sequence

        10         20         30         40         50         60 
MAALAAGISK QRAAAQGLGS NQNAVKYLGQ DFETLRKQCL NSGVLFKDPE FPACPSALGY 
        70         80         90        100        110        120 
RDLGPGSAET QGIIWKRPTE LCSNPQFIVG GATRTDIRQG GLGDCWLLAA IASLTLNEKL 
       130        140        150        160        170        180 
LYRVVPRDQS FQKNYAGIFH FQFWQYGEWV EVVIDDRLPT KNGQLLFLHS EEGNEFWSAL 
       190        200        210        220        230        240 
LEKAYAKLNG SYEALAGGST IEGFEDFTGG ISEFYDLRKP PGNLYYTIQK ALRKGSLLGC 
       250        260        270        280        290        300 
SIDVSNAAEA EATTRQKLVK GHAYSVTGVE EVDFRGLPEK LIRLRNPWGE VEWTGAWSDS 
       310        320        330        340        350        360 
APEWNYIDPQ KKGELDKRAE DGEFWMSFSD FLKQFSRLEI CNLSPDSLSS EEIHKWNLVL 
       370        380        390        400        410        420 
FNGRWTRGST AGGCQNYPAT YWTNPQFKIH LDEVDEDQEE GTSEPCCTVL LGLMQKNRRR 
       430        440        450        460        470        480 
QRRIGQGMLS IGYAVYQIPK ELENHTDEHL GRDFFQGRQP STCSSTYMNL REVSSRVQLP 
       490        500        510        520        530        540 
PGQYLVVPST FEPFKDGDFC LRVFSEKKAQ ALEIGDAVPG DPHEPHPRDM DGEDEHFWSL 
       550        560        570        580        590        600 
SEEFADKDSE ISAHQLKRVL NGLLSKRTDM KFDGFNINTC REMISLLDGD GTGSLRPVEF 
       610        620        630        640        650        660 
KTLWLKICKY LEIYQEMDHS RAGTIDAHEM RTALKKAGFT LNNQVQQTIA TRYACSKLGV 
       670        680        690        700    
DFDGFVACMI RLEILFKLFR LLDKDQNGIV QLSLAEWLCR ALV

Isoforms

- Isoform 2 of Calpain-8

Sequence View

        10         20         30         40         50         60 
MAALAAGISK QRAAAQGLGS NQNAVKYLGQ DFETLRKQCL NSGVLFKDPE FPACPSALGY 
        70         80         90        100        110        120 
RDLGPGSAET QGIIWKRPTE LCSNPQFIVG GATRTDIRQG GLGDCWLLAA IASLTLNEKL 
       130        140        150        160        170        180 
LYRVVPRDQS FQKNYAGIFH FQFWQYGEWV EVVIDDRLPT KNGQLLFLHS EEGNEFWSAL 
       190        200        210        220        230        240 
LEKAYAKLNG SYEALAGGST IEGFEDFTGG ISEFYDLRKP PGNLYYTIQK ALRKGSLLGC 
       250        260        270        280        290        300 
SIDVSNAAEA EATTRQKLVK GHAYSVTGVE EVDFRGLPEK LIRLRNPWGE VEWTGAWSDS 
       310        320        330        340        350        360 
APEWNYIDPQ KKGELDKRAE DGEFWMSFSD FLKQFSRLEI CNLSPDSLSS EEIHKWNLVL 
       370        380        390        400        410        420 
FNGRWTRGST AGGCQNYPAT YWTNPQFKIH LDEVDEDQEE GTSEPCCTVL LGLMQKNRRR 
       430        440        450        460        470        480 
QRRIGQGMLS IGYAVYQIPK ELENHTDEHL GRDFFQGRQP STCSSTYMNL REVSSRVQLP 
       490        500        510        520        530        540 
PGQYLVVPST FEPFKDGDFC LRVFSEKKAQ ALEIGDAVPG DPHEPHPRDM DGEDEHFWSL 
       550        560        570        580        590        600 
SEEFADKDSE ISAHQLKRVL NGLLSKRTDM KFDGFNINTC REMISLLDGD GTGSLRPVEF 
       610        620        630        640        650        660 
KTLWLKICKY LEIYQEMDHS RAGTIDAHEM RTALKKAGFT LNNQVQQTIA TRYACSKLGV 
       670        680        690        700    
DFDGFVACMI RLEILFKLFR LLDKDQNGIV QLSLAEWLCR ALV



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 1 Substrates

N-termini

C-termini

Cleavages

Substrates