Q91WC0: Actin-histidine N-methyltransferase {ECO:0000305}

General Information

Protein names	- Actin-histidine N-methyltransferase {ECO:0000305} - 2.1.1.85 {ECO:0000269\|PubMed:30626964} - Endothelial differentiation inhibitory protein D10 {ECO:0000303\|PubMed:16008511} - SET domain-containing protein 3 {ECO:0000305}
Gene names	Setd3
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q91WC0

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI
        70         80         90        100        110        120
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF
       130        140        150        160        170        180
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP
       190        200        210        220        230        240
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT
       250        260        270        280        290        300
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
       310        320        330        340        350        360
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA
       370        380        390        400        410        420
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW
       430        440        450        460        470        480
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK
       490        500        510        520        530        540
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE
       550        560        570        580        590
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL

Isoforms

- Isoform 2 of Histone-lysine N-methyltransferase setd3 - Isoform 3 of Histone-lysine N-methyltransferase setd3 - Isoform 4 of Histone-lysine N-methyltransferase setd3 - Isoform 2 of Actin-histidine N-methyltransferase - Isoform 3 of Actin-histidine N-methyltransferase - Isoform 4 of Actin-histidine N-methyltransferase

Sequence View

        10         20         30         40         50         60
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI
        70         80         90        100        110        120
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF
       130        140        150        160        170        180
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP
       190        200        210        220        230        240
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT
       250        260        270        280        290        300
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
       310        320        330        340        350        360
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA
       370        380        390        400        410        420
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW
       430        440        450        460        470        480
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK
       490        500        510        520        530        540
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE
       550        560        570        580        590
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL         10         20         30         40         50         60
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI
        70         80         90        100        110        120
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF
       130        140        150        160        170        180
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP
       190        200        210        220        230        240
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT
       250        260        270        280        290        300
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
       310        320        330        340        350        360
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA
       370        380        390        400        410        420
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW
       430        440        450        460        470        480
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK
       490        500        510        520        530        540
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE
       550        560        570        580        590
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL         10         20         30         40         50         60
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI
        70         80         90        100        110        120
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF
       130        140        150        160        170        180
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP
       190        200        210        220        230        240
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT
       250        260        270        280        290        300
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
       310        320        330        340        350        360
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA
       370        380        390        400        410        420
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW
       430        440        450        460        470        480
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK
       490        500        510        520        530        540
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE
       550        560        570        580        590
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL         10         20         30         40         50         60
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI
        70         80         90        100        110        120
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF
       130        140        150        160        170        180
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP
       190        200        210        220        230        240
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT
       250        260        270        280        290        300
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
       310        320        330        340        350        360
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA
       370        380        390        400        410        420
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW
       430        440        450        460        470        480
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK
       490        500        510        520        530        540
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE
       550        560        570        580        590
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL         10         20         30         40         50         60
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI
        70         80         90        100        110        120
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF
       130        140        150        160        170        180
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP
       190        200        210        220        230        240
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT
       250        260        270        280        290        300
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
       310        320        330        340        350        360
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA
       370        380        390        400        410        420
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW
       430        440        450        460        470        480
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK
       490        500        510        520        530        540
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE
       550        560        570        580        590
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL         10         20         30         40         50         60
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PSPGKEWEEY TQIRALVEKI
        70         80         90        100        110        120
RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF
       130        140        150        160        170        180
LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP
       190        200        210        220        230        240
SEYDTPLYFE EEEVRCLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKESFT
       250        260        270        280        290        300
YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL
       310        320        330        340        350        360
QDFQAGDQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA
       370        380        390        400        410        420
GIPTSSVFAL HSTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNAEFPVSW
       430        440        450        460        470        480
DNEVKLWTFL EDRASLLLKT YKTTIEEDKI VLKNPDLSVR ATMAIKLRLG EKEILEKAVK
       490        500        510        520        530        540
SAAVNREYYR KHMEERAPLP RYEESDLGLL EGGVGDSRLP LVLRKLEEEA GVQESLSLTE
       550        560        570        580        590
TVSKVKAAEN GLVNGENLIP NGTRSENESL SPEESENVTG EESSGSMAKV KERL

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q91WC0-1-unknown	MGKKSR...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q91WC0-129-unknown	MTVESA...	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89352
Q91WC0-129-unknown	MTVESA...	129	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89354
Q91WC0-352-unknown	MKAEVL...	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89353
Q91WC0-352-unknown	MKAEVL...	352	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt96334

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VKERL	594	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VKERL	594	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84971
...VKERL	594	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84970

TopFIND

Q91WC0: Actin-histidine N-methyltransferase {ECO:0000305}

General Information

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates