Q91ZX7: Prolow-density lipoprotein receptor-related protein 1
| Protein names | - Prolow-density lipoprotein receptor-related protein 1 - LRP-1 - Alpha-2-macroglobulin receptor - A2MR - CD91 - Low-density lipoprotein receptor-related protein 1 85 kDa subunit - LRP-85 - Low-density lipoprotein receptor-related protein 1 515 kDa subunit - LRP-515 - Low-density lipoprotein receptor-related protein 1 intracellular domain - LRPICD |
|---|---|
| Gene names | Lrp1 |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q91ZX7 |
3
N-termini
3
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLTPPLLLLL PLLSALVSGA TMDAPKTCSP KQFACRDQIT CISKGWRCDG ERDCPDGSDE
70 80 90 100 110 120
APEICPQSKA QRCPPNEHSC LGTELCVPMS RLCNGIQDCM DGSDEGAHCR ELRANCSRMG
130 140 150 160 170 180
CQHHCVPTPS GPTCYCNSSF QLQADGKTCK DFDECSVYGT CSQLCTNTDG SFTCGCVEGY
190 200 210 220 230 240
LLQPDNRSCK AKNEPVDRPP VLLIANSQNI LATYLSGAQV STITPTSTRQ TTAMDFSYAN
250 260 270 280 290 300
ETVCWVHVGD SAAQTQLKCA RMPGLKGFVD EHTINISLSL HHVEQMAIDW LTGNFYFVDD
310 320 330 340 350 360
IDDRIFVCNR NGDTCVTLLD LELYNPKGIA LDPAMGKVFF TDYGQIPKVE RCDMDGQNRT
370 380 390 400 410 420
KLVDSKIVFP HGITLDLVSR LVYWADAYLD YIEVVDYEGK GRQTIIQGIL IEHLYGLTVF
430 440 450 460 470 480
ENYLYATNSD NANTQQKTSV IRVNRFNSTE YQVVTRVDKG GALHIYHQRR QPRVRSHACE
490 500 510 520 530 540
NDQYGKPGGC SDICLLANSH KARTCRCRSG FSLGSDGKSC KKPEHELFLV YGKGRPGIIR
550 560 570 580 590 600
GMDMGAKVPD EHMIPIENLM NPRALDFHAE TGFIYFADTT SYLIGRQKID GTERETILKD
610 620 630 640 650 660
GIHNVEGVAV DWMGDNLYWT DDGPKKTISV ARLEKAAQTR KTLIEGKMTH PRAIVVDPLN
670 680 690 700 710 720
GWMYWTDWEE DPKDSRRGRL ERAWMDGSHR DIFVTSKTVL WPNGLSLDIP AGRLYWVDAF
730 740 750 760 770 780
YDRIETILLN GTDRKIVYEG PELNHAFGLC HHGNYLFWTE YRSGSVYRLE RGVAGAPPTV
790 800 810 820 830 840
TLLRSERPPI FEIRMYDAQQ QQVGTNKCRV NNGGCSSLCL ATPGSRQCAC AEDQVLDTDG
850 860 870 880 890 900
VTCLANPSYV PPPQCQPGEF ACANNRCIQE RWKCDGDNDC LDNSDEAPAL CHQHTCPSDR
910 920 930 940 950 960
FKCENNRCIP NRWLCDGDND CGNSEDESNA TCSARTCPPN QFSCASGRCI PISWTCDLDD
970 980 990 1000 1010 1020
DCGDRSDESA SCAYPTCFPL TQFTCNNGRC ININWRCDND NDCGDNSDEA GCSHSCSSTQ
1030 1040 1050 1060 1070 1080
FKCNSGRCIP EHWTCDGDND CGDYSDETHA NCTNQATRPP GGCHSDEFQC RLDGLCIPLR
1090 1100 1110 1120 1130 1140
WRCDGDTDCM DSSDEKSCEG VTHVCDPNVK FGCKDSARCI SKAWVCDGDS DCEDNSDEEN
1150 1160 1170 1180 1190 1200
CEALACRPPS HPCANNTSVC LPPDKLCDGK DDCGDGSDEG ELCDQCSLNN GGCSHNCSVA
1210 1220 1230 1240 1250 1260
PGEGIVCSCP LGMELGSDNH TCQIQSYCAK HLKCSQKCDQ NKFSVKCSCY EGWVLEPDGE
1270 1280 1290 1300 1310 1320
SCRSLDPFKP FIIFSNRHEI RRIDLHKGDY SVLVPGLRNT IALDFHLSQS ALYWTDVVED
1330 1340 1350 1360 1370 1380
KIYRGKLLDN GALTSFEVVI QYGLATPEGL AVDWIAGNIY WVESNLDQIE VAKLDGTLRT
1390 1400 1410 1420 1430 1440
TLLAGDIEHP RAIALDPRDG ILFWTDWDAS LPRIEAASMS GAGRRTIHRE TGSGGWPNGL
1450 1460 1470 1480 1490 1500
TVDYLEKRIL WIDARSDAIY SARYDGSGHM EVLRGHEFLS HPFAVTLYGG EVYWTDWRTN
1510 1520 1530 1540 1550 1560
TLAKANKWTG HNVTVVQRTN TQPFDLQVYH PSRQPMAPNP CEANGGRGPC SHLCLINYNR
1570 1580 1590 1600 1610 1620
TVSCACPHLM KLHKDNTTCY EFKKFLLYAR QMEIRGVDLD APYYNYIISF TVPDIDNVTV
1630 1640 1650 1660 1670 1680
LDYDAREQRV YWSDVRTQAI KRAFINGTGV ETVVSADLPN AHGLAVDWVS RNLFWTSYDT
1690 1700 1710 1720 1730 1740
NKKQINVARL DGSFKNAVVQ GLEQPHGLVV HPLRGKLYWT DGDNISMANM DGSNHTLLFS
1750 1760 1770 1780 1790 1800
GQKGPVGLAI DFPESKLYWI SSGNHTINRC NLDGSELEVI DTMRSQLGKA TALAIMGDKL
1810 1820 1830 1840 1850 1860
WWADQVSEKM GTCNKADGSG SVVLRNSTTL VMHMKVYDES IQLEHEGTNP CSVNNGDCSQ
1870 1880 1890 1900 1910 1920
LCLPTSETTR SCMCTAGYSL RSGQQACEGV GSFLLYSVHE GIRGIPLDPN DKSDALVPVS
1930 1940 1950 1960 1970 1980
GTSLAVGIDF HAENDTIYWV DMGLSTISRA KRDQTWREDV VTNGIGRVEG IAVDWIAGNI
1990 2000 2010 2020 2030 2040
YWTDQGFDVI EVARLNGSFR YVVISQGLDK PRAITVHPEK GYLFWTEWGH YPRIERSRLD
2050 2060 2070 2080 2090 2100
GTERVVLVNV SISWPNGISV DYQGGKLYWC DARMDKIERI DLETGENREV VLSSNNMDMF
2110 2120 2130 2140 2150 2160
SVSVFEDFIY WSDRTHANGS IKRGCKDNAT DSVPLRTGIG VQLKDIKVFN RDRQKGTNVC
2170 2180 2190 2200 2210 2220
AVANGGCQQL CLYRGGGQRA CACAHGMLAE DGASCREYAG YLLYSERTIL KSIHLSDERN
2230 2240 2250 2260 2270 2280
LNAPVQPFED PEHMKNVIAL AFDYRAGTSP GTPNRIFFSD IHFGNIQQIN DDGSGRTTIV
2290 2300 2310 2320 2330 2340
ENVGSVEGLA YHRGWDTLYW TSYTTSTITR HTVDQTRPGA FERETVITMS GDDHPRAFVL
2350 2360 2370 2380 2390 2400
DECQNLMFWT NWNELHPSIM RAALSGANVL TLIEKDIRTP NGLAIDHRAE KLYFSDATLD
2410 2420 2430 2440 2450 2460
KIERCEYDGS HRYVILKSEP VHPFGLAVYG EHIFWTDWVR RAVQRANKYV GSDMKLLRVD
2470 2480 2490 2500 2510 2520
IPQQPMGIIA VANDTNSCEL SPCRINNGGC QDLCLLTHQG HVNCSCRGGR ILQEDFTCRA
2530 2540 2550 2560 2570 2580
VNSSCRAQDE FECANGECIS FSLTCDGVSH CKDKSDEKPS YCNSRRCKKT FRQCNNGRCV
2590 2600 2610 2620 2630 2640
SNMLWCNGVD DCGDGSDEIP CNKTACGVGE FRCRDGSCIG NSSRCNQFVD CEDASDEMNC
2650 2660 2670 2680 2690 2700
SATDCSSYFR LGVKGVLFQP CERTSLCYAP SWVCDGANDC GDYSDERDCP GVKRPRCPLN
2710 2720 2730 2740 2750 2760
YFACPSGRCI PMSWTCDKED DCENGEDETH CNKFCSEAQF ECQNHRCISK QWLCDGSDDC
2770 2780 2790 2800 2810 2820
GDGSDEAAHC EGKTCGPSSF SCPGTHVCVP ERWLCDGDKD CTDGADESVT AGCLYNSTCD
2830 2840 2850 2860 2870 2880
DREFMCQNRL CIPKHFVCDH DRDCADGSDE SPECEYPTCG PNEFRCANGR CLSSRQWECD
2890 2900 2910 2920 2930 2940
GENDCHDHSD EAPKNPHCTS PEHKCNASSQ FLCSSGRCVA EALLCNGQDD CGDGSDERGC
2950 2960 2970 2980 2990 3000
HVNECLSRKL SGCSQDCEDL KIGFKCRCRP GFRLKDDGRT CADLDECSTT FPCSQLCINT
3010 3020 3030 3040 3050 3060
HGSYKCLCVE GYAPRGGDPH SCKAVTDEEP FLIFANRYYL RKLNLDGSNY TLLKQGLNNA
3070 3080 3090 3100 3110 3120
VALDFDYREQ MIYWTDVTTQ GSMIRRMHLN GSNVQVLHRT GLSNPDGLAV DWVGGNLYWC
3130 3140 3150 3160 3170 3180
DKGRDTIEVS KLNGAYRTVL VSSGLREPRA LVVDVQNGYL YWTDWGDHSL IGRIGMDGSG
3190 3200 3210 3220 3230 3240
RSIIVDTKIT WPNGLTVDYV TERIYWADAR EDYIEFASLD GSNRHVVLSQ DIPHIFALTL
3250 3260 3270 3280 3290 3300
FEDYVYWTDW ETKSINRAHK TTGANKTLLI STLHRPMDLH VFHALRQPDV PNHPCKVNNG
3310 3320 3330 3340 3350 3360
GCSNLCLLSP GGGHKCACPT NFYLGGDGRT CVSNCTASQF VCKNDKCIPF WWKCDTEDDC
3370 3380 3390 3400 3410 3420
GDHSDEPPDC PEFKCRPGQF QCSTGICTNP AFICDGDNDC QDNSDEANCD IHVCLPSQFK
3430 3440 3450 3460 3470 3480
CTNTNRCIPG IFRCNGQDNC GDGEDERDCP EVTCAPNQFQ CSITKRCIPR VWVCDRDNDC
3490 3500 3510 3520 3530 3540
VDGSDEPANC TQMTCGVDEF RCKDSGRCIP ARWKCDGEDD CGDGSDEPKE ECDERTCEPY
3550 3560 3570 3580 3590 3600
QFRCKNNRCV PGRWQCDYDN DCGDNSDEES CTPRPCSESE FSCANGRCIA GRWKCDGDHD
3610 3620 3630 3640 3650 3660
CADGSDEKDC TPRCDMDQFQ CKSGHCIPLR WRCDADADCM DGSDEEACGT GVRTCPLDEF
3670 3680 3690 3700 3710 3720
QCNNTLCKPL AWKCDGEDDC GDNSDENPEE CARFICPPNR PFRCKNDRVC LWIGRQCDGV
3730 3740 3750 3760 3770 3780
DNCGDGTDEE DCEPPTAQNP HCKDKKEFLC RNQRCLSSSL RCNMFDDCGD GSDEEDCSID
3790 3800 3810 3820 3830 3840
PKLTSCATNA SMCGDEARCV RTEKAAYCAC RSGFHTVPGQ PGCQDINECL RFGTCSQLCN
3850 3860 3870 3880 3890 3900
NTKGGHLCSC ARNFMKTHNT CKAEGSEYQV LYIADDNEIR SLFPGHPHSA YEQTFQGDES
3910 3920 3930 3940 3950 3960
VRIDAMDVHV KAGRVYWTNW HTGTISYRSL PPAAPPTTSN RHRRQIDRGV THLNISGLKM
3970 3980 3990 4000 4010 4020
PRGIAIDWVA GNVYWTDSGR DVIEVAQMKG ENRKTLISGM IDEPHAIVVD PLRGTMYWSD
4030 4040 4050 4060 4070 4080
WGNHPKIETA AMDGTLRETL VQDNIQWPTG LAVDYHNERL YWADAKLSVI GSIRLNGTDP
4090 4100 4110 4120 4130 4140
IVAADSKRGL SHPFSIDVFE DYIYGVTYIN NRVFKIHKFG HSPLINLTGG LSHASDVVLY
4150 4160 4170 4180 4190 4200
HQHKQPEVTN PCDRKKCEWL CLLSPSGPVC TCPNGKRLDN GTCVPVPSPT PPPDAPRPGT
4210 4220 4230 4240 4250 4260
CTLQCFNGGS CFLNARRQPK CRCQPRYTGD KCELDQCWEY CHNGGTCAAS PSGMPTCRCP
4270 4280 4290 4300 4310 4320
TGFTGPKCTA QVCAGYCSNN STCTVNQGNQ PQCRCLPGFL GDRCQYRQCS GFCENFGTCQ
4330 4340 4350 4360 4370 4380
MAADGSRQCR CTVYFEGPRC EVNKCSRCLQ GACVVNKQTG DVTCNCTDGR VAPSCLTCID
4390 4400 4410 4420 4430 4440
HCSNGGSCTM NSKMMPECQC PPHMTGPRCE EQVVSQQQPG HMASILIPLL LLLLLLLVAG
4450 4460 4470 4480 4490 4500
VVFWYKRRVR GAKGFQHQRM TNGAMNVEIG NPTYKMYEGG EPDDVGGLLD ADFALDPDKP
4510 4520 4530 4540
TNFTNPVYAT LYMGGHGSRH SLASTDEKRE LLGRGPEDEI GDPLA
Isoforms
Sequence View
Protein Neighborhood
Domains & Features
3 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q91ZX7-20-unknown | ATMDAP... | 20 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q91ZX7-3945-unknown | QIDRGV... | 3945 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q91ZX7-4442-unknown | VFWYKR... | 4442 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...HANCTN | 1053 | inferred from electronic annotation | unknown | Ensembl | inferred from ensembl protein ENSMUSP00000115305 | |||
| ...NRHRRQ | 3944 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...GDPLA | 4545 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|