TopFIND 4.0

Q920B6: Potassium channel subfamily K member 2 {ECO:0000250|UniProtKB:O95069}

General Information

Protein names
- Potassium channel subfamily K member 2 {ECO:0000250|UniProtKB:O95069}
- Outward rectifying potassium channel protein TREK-1 {ECO:0000250|UniProtKB:O95069}
- Stretch-activated potassium channel TREK-1 {ECO:0000303|PubMed:16248991}
- TREK-1 K(+) channel subunit {ECO:0000250|UniProtKB:O95069}
- Two pore domain potassium channel TREK-1 {ECO:0000303|PubMed:24196565}
- Two pore potassium channel TPKC1 {ECO:0000250|UniProtKB:O95069}
Gene names Kcnk2 {ECO:0000312|EMBL:AAU06141.1, ECO:0000312|Ensembl:ENSRNOP00000003684, ECO:0000312|RGD:621448}
Organism Rattus norvegicus
Protease Family
Protease ID
Chromosome location
UniProt ID Q920B6

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLASASRERP GYTAGVAAPD LLDPKSAAQN SKPRLSFSAK PTVLASRVES DSAINVMKWK 
        70         80         90        100        110        120 
TVSTIFLVVV LYLIIGATVF KALEQPQEIS QRTTIVIQKQ NFIAQHACVN STELDELIQQ 
       130        140        150        160        170        180 
IVTAINAGII PLGNNSNQVS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL 
       190        200        210        220        230        240 
GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL 
       250        260        270        280        290        300 
PAVIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 
       310        320        330        340        350        360 
AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS 
       370        380        390        400        410        420 
VKRKLSAELA GNHNQELTPC RRTLSVNHLT SEREVLPPLL KAESIYLNGL TPHCAAEDIA 
   
VIENMK

Isoforms

- Isoform 2 of Potassium channel subfamily K member 2 - Isoform 3 of Potassium channel subfamily K member 2 - Isoform 4 of Potassium channel subfamily K member 2 - Isoform 5 of Potassium channel subfamily K member 2

Sequence View

        10         20         30         40         50         60 
MLASASRERP GYTAGVAAPD LLDPKSAAQN SKPRLSFSAK PTVLASRVES DSAINVMKWK 
        70         80         90        100        110        120 
TVSTIFLVVV LYLIIGATVF KALEQPQEIS QRTTIVIQKQ NFIAQHACVN STELDELIQQ 
       130        140        150        160        170        180 
IVTAINAGII PLGNNSNQVS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL 
       190        200        210        220        230        240 
GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL 
       250        260        270        280        290        300 
PAVIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 
       310        320        330        340        350        360 
AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS 
       370        380        390        400        410        420 
VKRKLSAELA GNHNQELTPC RRTLSVNHLT SEREVLPPLL KAESIYLNGL TPHCAAEDIA 
   
VIENMK         10         20         30         40         50         60 
MLASASRERP GYTAGVAAPD LLDPKSAAQN SKPRLSFSAK PTVLASRVES DSAINVMKWK 
        70         80         90        100        110        120 
TVSTIFLVVV LYLIIGATVF KALEQPQEIS QRTTIVIQKQ NFIAQHACVN STELDELIQQ 
       130        140        150        160        170        180 
IVTAINAGII PLGNNSNQVS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL 
       190        200        210        220        230        240 
GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL 
       250        260        270        280        290        300 
PAVIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 
       310        320        330        340        350        360 
AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS 
       370        380        390        400        410        420 
VKRKLSAELA GNHNQELTPC RRTLSVNHLT SEREVLPPLL KAESIYLNGL TPHCAAEDIA 
   
VIENMK         10         20         30         40         50         60 
MLASASRERP GYTAGVAAPD LLDPKSAAQN SKPRLSFSAK PTVLASRVES DSAINVMKWK 
        70         80         90        100        110        120 
TVSTIFLVVV LYLIIGATVF KALEQPQEIS QRTTIVIQKQ NFIAQHACVN STELDELIQQ 
       130        140        150        160        170        180 
IVTAINAGII PLGNNSNQVS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL 
       190        200        210        220        230        240 
GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL 
       250        260        270        280        290        300 
PAVIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 
       310        320        330        340        350        360 
AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS 
       370        380        390        400        410        420 
VKRKLSAELA GNHNQELTPC RRTLSVNHLT SEREVLPPLL KAESIYLNGL TPHCAAEDIA 
   
VIENMK         10         20         30         40         50         60 
MLASASRERP GYTAGVAAPD LLDPKSAAQN SKPRLSFSAK PTVLASRVES DSAINVMKWK 
        70         80         90        100        110        120 
TVSTIFLVVV LYLIIGATVF KALEQPQEIS QRTTIVIQKQ NFIAQHACVN STELDELIQQ 
       130        140        150        160        170        180 
IVTAINAGII PLGNNSNQVS HWDLGSSFFF AGTVITTIGF GNISPRTEGG KIFCIIYALL 
       190        200        210        220        230        240 
GIPLFGFLLA GVGDQLGTIF GKGIAKVEDT FIKWNVSQTK IRIISTIIFI LFGCVLFVAL 
       250        260        270        280        290        300 
PAVIFKHIEG WSALDAIYFV VITLTTIGFG DYVAGGSDIE YLDFYKPVVW FWILVGLAYF 
       310        320        330        340        350        360 
AAVLSMIGDW LRVISKKTKE EVGEFRAHAA EWTANVTAEF KETRRRLSVE IYDKFQRATS 
       370        380        390        400        410        420 
VKRKLSAELA GNHNQELTPC RRTLSVNHLT SEREVLPPLL KAESIYLNGL TPHCAAEDIA 
   
VIENMK



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Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q920B6-1-unknown MLASAS... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)