Q923E4: NAD-dependent protein deacetylase sirtuin-1

General Information

Protein names	- NAD-dependent protein deacetylase sirtuin-1 - 3.5.1.- {ECO:0000269\|PubMed:20167603, ECO:0000269\|PubMed:28883095} - Regulatory protein SIR2 homolog 1 - SIR2-like protein 1 - SIR2alpha - Sir2 - mSIR2a - SirtT1 75 kDa fragment - 75SirT1
Gene names	Sirt1
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q923E4

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MADEVALALQ AAGSPSAAAA MEAASQPADE PLRKRPRRDG PGLGRSPGEP SAAVAPAAAG
        70         80         90        100        110        120
CEAASAAAPA ALWREAAGAA ASAEREAPAT AVAGDGDNGS GLRREPRAAD DFDDDEGEEE
       130        140        150        160        170        180
DEAAAAAAAA AIGYRDNLLL TDGLLTNGFH SCESDDDDRT SHASSSDWTP RPRIGPYTFV
       190        200        210        220        230        240
QQHLMIGTDP RTILKDLLPE TIPPPELDDM TLWQIVINIL SEPPKRKKRK DINTIEDAVK
       250        260        270        280        290        300
LLQECKKIIV LTGAGVSVSC GIPDFRSRDG IYARLAVDFP DLPDPQAMFD IEYFRKDPRP
       310        320        330        340        350        360
FFKFAKEIYP GQFQPSLCHK FIALSDKEGK LLRNYTQNID TLEQVAGIQR ILQCHGSFAT
       370        380        390        400        410        420
ASCLICKYKV DCEAVRGDIF NQVVPRCPRC PADEPLAIMK PEIVFFGENL PEQFHRAMKY
       430        440        450        460        470        480
DKDEVDLLIV IGSSLKVRPV ALIPSSIPHE VPQILINREP LPHLHFDVEL LGDCDVIINE
       490        500        510        520        530        540
LCHRLGGEYA KLCCNPVKLS EITEKPPRPQ KELVHLSELP PTPLHISEDS SSPERTVPQD
       550        560        570        580        590        600
SSVIATLVDQ ATNNNVNDLE VSESSCVEEK PQEVQTSRNV ENINVENPDF KAVGSSTADK
       610        620        630        640        650        660
NERTSVAETV RKCWPNRLAK EQISKRLEGN QYLFVPPNRY IFHGAEVYSD SEDDVLSSSS
       670        680        690        700        710        720
CGSNSDSGTC QSPSLEEPLE DESEIEEFYN GLEDDTERPE CAGGSGFGAD GGDQEVVNEA
       730
IATRQELTDV NYPSDKS

Isoforms

- Isoform 2 of NAD-dependent protein deacetylase sirtuin-1

Sequence View

        10         20         30         40         50         60
MADEVALALQ AAGSPSAAAA MEAASQPADE PLRKRPRRDG PGLGRSPGEP SAAVAPAAAG
        70         80         90        100        110        120
CEAASAAAPA ALWREAAGAA ASAEREAPAT AVAGDGDNGS GLRREPRAAD DFDDDEGEEE
       130        140        150        160        170        180
DEAAAAAAAA AIGYRDNLLL TDGLLTNGFH SCESDDDDRT SHASSSDWTP RPRIGPYTFV
       190        200        210        220        230        240
QQHLMIGTDP RTILKDLLPE TIPPPELDDM TLWQIVINIL SEPPKRKKRK DINTIEDAVK
       250        260        270        280        290        300
LLQECKKIIV LTGAGVSVSC GIPDFRSRDG IYARLAVDFP DLPDPQAMFD IEYFRKDPRP
       310        320        330        340        350        360
FFKFAKEIYP GQFQPSLCHK FIALSDKEGK LLRNYTQNID TLEQVAGIQR ILQCHGSFAT
       370        380        390        400        410        420
ASCLICKYKV DCEAVRGDIF NQVVPRCPRC PADEPLAIMK PEIVFFGENL PEQFHRAMKY
       430        440        450        460        470        480
DKDEVDLLIV IGSSLKVRPV ALIPSSIPHE VPQILINREP LPHLHFDVEL LGDCDVIINE
       490        500        510        520        530        540
LCHRLGGEYA KLCCNPVKLS EITEKPPRPQ KELVHLSELP PTPLHISEDS SSPERTVPQD
       550        560        570        580        590        600
SSVIATLVDQ ATNNNVNDLE VSESSCVEEK PQEVQTSRNV ENINVENPDF KAVGSSTADK
       610        620        630        640        650        660
NERTSVAETV RKCWPNRLAK EQISKRLEGN QYLFVPPNRY IFHGAEVYSD SEDDVLSSSS
       670        680        690        700        710        720
CGSNSDSGTC QSPSLEEPLE DESEIEEFYN GLEDDTERPE CAGGSGFGAD GGDQEVVNEA
       730
IATRQELTDV NYPSDKS

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q923E4-2-unknown	MADEVA...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q923E4-2-unknown	MADEVA...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q923E4-1-unknown	MADEVA...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt89787
Q923E4-2-Acetylation	ADEVAL...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q923E4-2-Acetylation	ADEVAL...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt110279
Q923E4-2-Acetylation	ADEVAL...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...PTPLHI	525	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSDKS	737	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PSDKS	737	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt85405

TopFIND

Q923E4: NAD-dependent protein deacetylase sirtuin-1

General Information

3

N-termini

2

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates