TopFIND 4.0

Q92565: Rap guanine nucleotide exchange factor 5

General Information

Protein names
- Rap guanine nucleotide exchange factor 5
- Guanine nucleotide exchange factor for Rap1
- M-Ras-regulated Rap GEF
- MR-GEF
- Related to Epac
- Repac
Gene names RAPGEF5
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q92565

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGSSRLRVFD PHLERKDSAA ALSDRELPLP TFDVPYFKYI DEEDEDDEWS SRSQSSTEDD 
        70         80         90        100        110        120 
SVDSLLSDRY VVVSGTPEKI LEHLLNDLHL EEVQDKETET LLDDFLLTYT VFMTTDDLCQ 
       130        140        150        160        170        180 
ALLRHYSAKK YQGKEENSDV PRRKRKVLHL VSQWIALYKD WLPEDEHSKM FLKTIYRNVL 
       190        200        210        220        230        240 
DDVYEYPILE KELKEFQKIL GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET 
       250        260        270        280        290        300 
EEIFCHVYIT EHSYVSVKAK VSSIAQEILK VVAEKIQYAE EDLALVAITF SGEKHELQPN 
       310        320        330        340        350        360 
DLVISKSLEA SGRIYVYRKD LADTLNPFAE NEESQQRSMR ILGMNTWDLA LELMNFDWSL 
       370        380        390        400        410        420 
FNSIHEQELI YFTFSRQGSG EHTANLSLLL QRCNEVQLWV ATEILLCSQL GKRVQLVKKF 
       430        440        450        460        470        480 
IKIAAHCKAQ RNLNSFFAIV MGLNTASVSR LSQTWEKIPG KFKKLFSELE SLTDPSLNHK 
       490        500        510        520        530        540 
AYRDAFKKMK PPKIPFMPLL LKDVTFIHEG NKTFLDNLVN FEKLHMIADT VRTLRHCRTN 
       550        560        570        580    
QFGDLSPKEH QELKSYVNHL YVIDSQQALF ELSHRIEPRV 

Isoforms

- Isoform 2 of Rap guanine nucleotide exchange factor 5

Sequence View

        10         20         30         40         50         60 
MGSSRLRVFD PHLERKDSAA ALSDRELPLP TFDVPYFKYI DEEDEDDEWS SRSQSSTEDD 
        70         80         90        100        110        120 
SVDSLLSDRY VVVSGTPEKI LEHLLNDLHL EEVQDKETET LLDDFLLTYT VFMTTDDLCQ 
       130        140        150        160        170        180 
ALLRHYSAKK YQGKEENSDV PRRKRKVLHL VSQWIALYKD WLPEDEHSKM FLKTIYRNVL 
       190        200        210        220        230        240 
DDVYEYPILE KELKEFQKIL GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET 
       250        260        270        280        290        300 
EEIFCHVYIT EHSYVSVKAK VSSIAQEILK VVAEKIQYAE EDLALVAITF SGEKHELQPN 
       310        320        330        340        350        360 
DLVISKSLEA SGRIYVYRKD LADTLNPFAE NEESQQRSMR ILGMNTWDLA LELMNFDWSL 
       370        380        390        400        410        420 
FNSIHEQELI YFTFSRQGSG EHTANLSLLL QRCNEVQLWV ATEILLCSQL GKRVQLVKKF 
       430        440        450        460        470        480 
IKIAAHCKAQ RNLNSFFAIV MGLNTASVSR LSQTWEKIPG KFKKLFSELE SLTDPSLNHK 
       490        500        510        520        530        540 
AYRDAFKKMK PPKIPFMPLL LKDVTFIHEG NKTFLDNLVN FEKLHMIADT VRTLRHCRTN 
       550        560        570        580    
QFGDLSPKEH QELKSYVNHL YVIDSQQALF ELSHRIEPRV 



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q92565-1-unknown MGSSRL... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q92565-1-unknown MGSSRL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt88146

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...IEPRV 580 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...IEPRV 580 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt83764

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)