Q92599: Septin-8 {ECO:0000305}

General Information

Protein names	- Septin-8 {ECO:0000305}
Gene names	SEPT8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q92599

4 N-termini

5 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Septin-8 - Isoform 3 of Septin-8 - Isoform 4 of Septin-8

Sequence View

        10         20         30         40         50         60
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL
        70         80         90        100        110        120
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI
       130        140        150        160        170        180
VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN
       190        200        210        220        230        240
IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV
       250        260        270        280        290        300
GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
       310        320        330        340        350        360
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK
       370        380        390        400        410        420
EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP
       430        440        450        460        470        480
LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT KASVEPLNCS SWWPAIQCCS CLVRDATWRE

GFL         10         20         30         40         50         60
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL
        70         80         90        100        110        120
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI
       130        140        150        160        170        180
VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN
       190        200        210        220        230        240
IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV
       250        260        270        280        290        300
GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
       310        320        330        340        350        360
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK
       370        380        390        400        410        420
EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP
       430        440        450        460        470        480
LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT KASVEPLNCS SWWPAIQCCS CLVRDATWRE

GFL         10         20         30         40         50         60
MAATDLERFS NAEPEPRSLS LGGHVGFDSL PDQLVSKSVT QGFSFNILCV GETGIGKSTL
        70         80         90        100        110        120
MNTLFNTTFE TEEASHHEAC VRLRPQTYDL QESNVQLKLT IVDAVGFGDQ INKDESYRPI
       130        140        150        160        170        180
VDYIDAQFEN YLQEELKIRR SLFDYHDTRI HVCLYFITPT GHSLKSLDLV TMKKLDSKVN
       190        200        210        220        230        240
IIPIIAKADT ISKSELHKFK IKIMGELVSN GVQIYQFPTD DEAVAEINAV MNAHLPFAVV
       250        260        270        280        290        300
GSTEEVKVGN KLVRARQYPW GVVQVENENH CDFVKLREML IRVNMEDLRE QTHSRHYELY
       310        320        330        340        350        360
RRCKLEEMGF QDSDGDSQPF SLQETYEAKR KEFLSELQRK EEEMRQMFVN KVKETELELK
       370        380        390        400        410        420
EKERELHEKF EHLKRVHQEE KRKVEEKRRE LEEETNAFNR RKAAVEALQS QALHATSQQP
       430        440        450        460        470        480
LRKDKDKKNR SDIGAHQPGM SLSSSKVMMT KASVEPLNCS SWWPAIQCCS CLVRDATWRE

GFL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 5 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q92599-2-unknown	MAATDL...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92599-1-unknown	MAATDL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89298
Q92599-1-unknown	MAATDL...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89300
Q92599-2-Acetylation	AATDLE...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q92599-2-Acetylation	AATDLE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q92599-2-Acetylation	AATDLE...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q92599-2-Acetylation	AATDLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110308
Q92599-2-Acetylation	AATDLE...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110309
Q92599-61-unknown	MNTLFN...	61		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt89299
Q92599-61-unknown	MNTLFN...	61		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000367971
Q92599-61-unknown	MNTLFN...	61		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000407421
Q92599-61-unknown	MNTLFN...	61		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000411823
Q92599-61-unknown	MNTLFN...	61		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000360548
Q92599-61-unknown	MNTLFN...	61		inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399840
Q92599-61-unknown	MNTLFN...	61		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107715
Q92599-61-unknown	MNTLFN...	61		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt107716

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...EELKIR	138	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000360548
...EELKIR	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154830
...EELKIR	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154829
...EELKIR	138	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154831
...CLYFIT	157	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000411823
...CLYFIT	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155057
...CLYFIT	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155056
...CLYFIT	157	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155058
...ADTISK	192	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000407421
...ADTISK	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155542
...ADTISK	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155541
...ADTISK	192	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt155543
...KDKKNR	429	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84917
...KDKKNR	429	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt84916
...KDKKNR	429	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000296873
...KDKKNR	429	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000367971
...KDKKNR	429	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000399840
...REGFL	483	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)