TopFIND 4.0

Q92630: Dual specificity tyrosine-phosphorylation-regulated kinase 2

General Information

Protein names
- Dual specificity tyrosine-phosphorylation-regulated kinase 2
- 2.7.12.1
Gene names DYRK2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q92630

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MLTRKPSAAA PAAYPTGRGG DSAVRQLQAS PGLGAGATRS GVGTGPPSPI ALPPLRASNA 
        70         80         90        100        110        120 
AAAAHTIGGS KHTMNDHLHV GSHAHGQIQV QQLFEDNSNK RTVLTTQPNG LTTVGKTGLP 
       130        140        150        160        170        180 
VVPERQLDSI HRRQGSSTSL KSMEGMGKVK ATPMTPEQAM KQYMQKLTAF EHHEIFSYPE 
       190        200        210        220        230        240 
IYFLGLNAKK RQGMTGGPNN GGYDDDQGSY VQVPHDHVAY RYEVLKVIGK GSFGQVVKAY 
       250        260        270        280        290        300 
DHKVHQHVAL KMVRNEKRFH RQAAEEIRIL EHLRKQDKDN TMNVIHMLEN FTFRNHICMT 
       310        320        330        340        350        360 
FELLSMNLYE LIKKNKFQGF SLPLVRKFAH SILQCLDALH KNRIIHCDLK PENILLKQQG 
       370        380        390        400        410        420 
RSGIKVIDFG SSCYEHQRVY TYIQSRFYRA PEVILGARYG MPIDMWSLGC ILAELLTGYP 
       430        440        450        460        470        480 
LLPGEDEGDQ LACMIELLGM PSQKLLDASK RAKNFVSSKG YPRYCTVTTL SDGSVVLNGG 
       490        500        510        520        530        540 
RSRRGKLRGP PESREWGNAL KGCDDPLFLD FLKQCLEWDP AVRMTPGQAL RHPWLRRRLP 
       550        560        570        580        590        600 
KPPTGEKTSV KRITESTGAI TSISKLPPPS SSASKLRTNL AQMTDANGNI QQRTVLPKLV 
   
S

Isoforms

- Isoform 2 of Dual specificity tyrosine-phosphorylation-regulated kinase 2

Sequence View

        10         20         30         40         50         60 
MLTRKPSAAA PAAYPTGRGG DSAVRQLQAS PGLGAGATRS GVGTGPPSPI ALPPLRASNA 
        70         80         90        100        110        120 
AAAAHTIGGS KHTMNDHLHV GSHAHGQIQV QQLFEDNSNK RTVLTTQPNG LTTVGKTGLP 
       130        140        150        160        170        180 
VVPERQLDSI HRRQGSSTSL KSMEGMGKVK ATPMTPEQAM KQYMQKLTAF EHHEIFSYPE 
       190        200        210        220        230        240 
IYFLGLNAKK RQGMTGGPNN GGYDDDQGSY VQVPHDHVAY RYEVLKVIGK GSFGQVVKAY 
       250        260        270        280        290        300 
DHKVHQHVAL KMVRNEKRFH RQAAEEIRIL EHLRKQDKDN TMNVIHMLEN FTFRNHICMT 
       310        320        330        340        350        360 
FELLSMNLYE LIKKNKFQGF SLPLVRKFAH SILQCLDALH KNRIIHCDLK PENILLKQQG 
       370        380        390        400        410        420 
RSGIKVIDFG SSCYEHQRVY TYIQSRFYRA PEVILGARYG MPIDMWSLGC ILAELLTGYP 
       430        440        450        460        470        480 
LLPGEDEGDQ LACMIELLGM PSQKLLDASK RAKNFVSSKG YPRYCTVTTL SDGSVVLNGG 
       490        500        510        520        530        540 
RSRRGKLRGP PESREWGNAL KGCDDPLFLD FLKQCLEWDP AVRMTPGQAL RHPWLRRRLP 
       550        560        570        580        590        600 
KPPTGEKTSV KRITESTGAI TSISKLPPPS SSASKLRTNL AQMTDANGNI QQRTVLPKLV 
   
S



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q92630-1-unknown MLTRKP... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q92630-74-unknown MNDHLH... 74 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73447

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...PKLVS 601 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...PKLVS 601 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt69065

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)