TopFIND 4.0

Q92813: Type II iodothyronine deiodinase

General Information

Protein names
- Type II iodothyronine deiodinase
- 1.21.99.4
- 5DII
- DIOII
- Type 2 DI
- Type-II 5'-deiodinase
Gene names DIO2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q92813

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE WRRMLTSEGL 
        70         80         90        100        110        120 
RCVWKSFLLD AYKQVKLGED APNSSVVHVS STEGGDNSGN GTQEKIAEGA TCHLLDFASP 
       130        140        150        160        170        180 
ERPLVVNFGS ATUPPFTSQL PAFRKLVEEF SSVADFLLVY IDEAHPSDGW AIPGDSSLSF 
       190        200        210        220        230        240 
EVKKHQNQED RCAAAQQLLE RFSLPPQCRV VADRMDNNAN IAYGVAFERV CIVQRQKIAY 
       250        260        270    
LGGKGPFSYN LQEVRHWLEK NFSKRUKKTR LAG

Isoforms

- Isoform 2 of Type II iodothyronine deiodinase - Isoform 3 of Type II iodothyronine deiodinase

Sequence View

        10         20         30         40         50         60 
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE WRRMLTSEGL 
        70         80         90        100        110        120 
RCVWKSFLLD AYKQVKLGED APNSSVVHVS STEGGDNSGN GTQEKIAEGA TCHLLDFASP 
       130        140        150        160        170        180 
ERPLVVNFGS ATUPPFTSQL PAFRKLVEEF SSVADFLLVY IDEAHPSDGW AIPGDSSLSF 
       190        200        210        220        230        240 
EVKKHQNQED RCAAAQQLLE RFSLPPQCRV VADRMDNNAN IAYGVAFERV CIVQRQKIAY 
       250        260        270    
LGGKGPFSYN LQEVRHWLEK NFSKRUKKTR LAG         10         20         30         40         50         60 
MGILSVDLLI TLQILPVFFS NCLFLALYDS VILLKHVVLL LSRSKSTRGE WRRMLTSEGL 
        70         80         90        100        110        120 
RCVWKSFLLD AYKQVKLGED APNSSVVHVS STEGGDNSGN GTQEKIAEGA TCHLLDFASP 
       130        140        150        160        170        180 
ERPLVVNFGS ATUPPFTSQL PAFRKLVEEF SSVADFLLVY IDEAHPSDGW AIPGDSSLSF 
       190        200        210        220        230        240 
EVKKHQNQED RCAAAQQLLE RFSLPPQCRV VADRMDNNAN IAYGVAFERV CIVQRQKIAY 
       250        260        270    
LGGKGPFSYN LQEVRHWLEK NFSKRUKKTR LAG



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q92813-1-unknown MGILSV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q92813-1-unknown MGILSV... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt77986

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...TRLAG 273 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...TRLAG 273 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt73604

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)