TopFIND 4.0

Q969P6: DNA topoisomerase I, mitochondrial

General Information

Protein names
- DNA topoisomerase I, mitochondrial
- TOP1mt
- 5.6.2.2 {ECO:0000255|PROSITE-ProRule:PRU10130}
Gene names TOP1MT
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q969P6

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRVVRLLRLR AALTLLGEVP RRPASRGVPG SRRTQKGSGA RWEKEKHEDG VKWRQLEHKG 
        70         80         90        100        110        120 
PYFAPPYEPL PDGVRFFYEG RPVRLSVAAE EVATFYGRML DHEYTTKEVF RKNFFNDWRK 
       130        140        150        160        170        180 
EMAVEEREVI KSLDKCDFTE IHRYFVDKAA ARKVLSREEK QKLKEEAEKL QQEFGYCILD 
       190        200        210        220        230        240 
GHQEKIGNFK IEPPGLFRGR GDHPKMGMLK RRITPEDVVI NCSRDSKIPE PPAGHQWKEV 
       250        260        270        280        290        300 
RSDNTVTWLA AWTESVQNSI KYIMLNPCSK LKGETAWQKF ETARRLRGFV DEIRSQYRAD 
       310        320        330        340        350        360 
WKSREMKTRQ RAVALYFIDK LALRAGNEKE DGEAADTVGC CSLRVEHVQL HPEADGCQHV 
       370        380        390        400        410        420 
VEFDFLGKDC IRYYNRVPVE KPVYKNLQLF MENKDPRDDL FDRLTTTSLN KHLQELMDGL 
       430        440        450        460        470        480 
TAKVFRTYNA SITLQEQLRA LTRAEDSIAA KILSYNRANR VVAILCNHQR ATPSTFEKSM 
       490        500        510        520        530        540 
QNLQTKIQAK KEQVAEARAE LRRARAEHKA QGDGKSRSVL EKKRRLLEKL QEQLAQLSVQ 
       550        560        570        580        590        600 
ATDKEENKQV ALGTSKLNYL DPRISIAWCK RFRVPVEKIY SKTQRERFAW ALAMAGEDFE 
   
F

Isoforms

- Isoform 2 of DNA topoisomerase I, mitochondrial

Sequence View

        10         20         30         40         50         60 
MRVVRLLRLR AALTLLGEVP RRPASRGVPG SRRTQKGSGA RWEKEKHEDG VKWRQLEHKG 
        70         80         90        100        110        120 
PYFAPPYEPL PDGVRFFYEG RPVRLSVAAE EVATFYGRML DHEYTTKEVF RKNFFNDWRK 
       130        140        150        160        170        180 
EMAVEEREVI KSLDKCDFTE IHRYFVDKAA ARKVLSREEK QKLKEEAEKL QQEFGYCILD 
       190        200        210        220        230        240 
GHQEKIGNFK IEPPGLFRGR GDHPKMGMLK RRITPEDVVI NCSRDSKIPE PPAGHQWKEV 
       250        260        270        280        290        300 
RSDNTVTWLA AWTESVQNSI KYIMLNPCSK LKGETAWQKF ETARRLRGFV DEIRSQYRAD 
       310        320        330        340        350        360 
WKSREMKTRQ RAVALYFIDK LALRAGNEKE DGEAADTVGC CSLRVEHVQL HPEADGCQHV 
       370        380        390        400        410        420 
VEFDFLGKDC IRYYNRVPVE KPVYKNLQLF MENKDPRDDL FDRLTTTSLN KHLQELMDGL 
       430        440        450        460        470        480 
TAKVFRTYNA SITLQEQLRA LTRAEDSIAA KILSYNRANR VVAILCNHQR ATPSTFEKSM 
       490        500        510        520        530        540 
QNLQTKIQAK KEQVAEARAE LRRARAEHKA QGDGKSRSVL EKKRRLLEKL QEQLAQLSVQ 
       550        560        570        580        590        600 
ATDKEENKQV ALGTSKLNYL DPRISIAWCK RFRVPVEKIY SKTQRERFAW ALAMAGEDFE 
   
F



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(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q969P6-51-unknown VKWRQL... 51 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q969P6-99-unknown MLDHEY... 99 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt92760

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EDFEF 601 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EDFEF 601 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt88378

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)