TopFIND 4.0

Q96BI3: Gamma-secretase subunit APH-1A

General Information

Protein names
- Gamma-secretase subunit APH-1A
- APH-1a
- Aph-1alpha
- Presenilin-stabilization factor
Gene names APH1A
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q96BI3

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT 
        70         80         90        100        110        120 
DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV 
       130        140        150        160        170        180 
SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD 
       190        200        210        220        230        240 
ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ 
       250        260    
RSLLCRRQED SRVMVYSALR IPPED

Isoforms

- Isoform 2 of Gamma-secretase subunit APH-1A - Isoform 3 of Gamma-secretase subunit APH-1A

Sequence View

        10         20         30         40         50         60 
MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT 
        70         80         90        100        110        120 
DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV 
       130        140        150        160        170        180 
SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD 
       190        200        210        220        230        240 
ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ 
       250        260    
RSLLCRRQED SRVMVYSALR IPPED         10         20         30         40         50         60 
MGAAVFFGCT FVAFGPAFAL FLITVAGDPL RVIILVAGAF FWLVSLLLAS VVWFILVHVT 
        70         80         90        100        110        120 
DRSDARLQYG LLIFGAAVSV LLQEVFRFAY YKLLKKADEG LASLSEDGRS PISIRQMAYV 
       130        140        150        160        170        180 
SGLSFGIISG VFSVINILAD ALGPGVVGIH GDSPYYFLTS AFLTAAIILL HTFWGVVFFD 
       190        200        210        220        230        240 
ACERRRYWAL GLVVGSHLLT SGLTFLNPWY EASLLPIYAV TVSMGLWAFI TAGGSLRSIQ 
       250        260    
RSLLCRRQED SRVMVYSALR IPPED



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Physiological Relevance:


Evidence Codes:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q96BI3-1-unknown MGAAVF... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q96BI3-1-unknown MGAAVF... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt67221
    Q96BI3-1-unknown MGAAVF... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt67222

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...IPPED 265 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...IPPED 265 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt62840

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)