Q96CV9: Optineurin

General Information

Protein names	- Optineurin - E3-14.7K-interacting protein - FIP-2 - Huntingtin yeast partner L - Huntingtin-interacting protein 7 - HIP-7 - Huntingtin-interacting protein L - NEMO-related protein - Optic neuropathy-inducing protein - Transcription factor IIIA-interacting protein - TFIIIA-IntP
Gene names	OPTN
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96CV9

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL
        70         80         90        100        110        120
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER
       130        140        150        160        170        180
SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE
       190        200        210        220        230        240
IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL
       250        260        270        280        290        300
REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE
       310        320        330        340        350        360
ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK
       370        380        390        400        410        420
LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR
       430        440        450        460        470        480
AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA
       490        500        510        520        530        540
AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE
       550        560        570
DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII

Isoforms

- Isoform 2 of Optineurin - Isoform 3 of Optineurin - Isoform 2 of Optineurin - Isoform 3 of Optineurin

Sequence View

        10         20         30         40         50         60
MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL
        70         80         90        100        110        120
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER
       130        140        150        160        170        180
SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE
       190        200        210        220        230        240
IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL
       250        260        270        280        290        300
REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE
       310        320        330        340        350        360
ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK
       370        380        390        400        410        420
LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR
       430        440        450        460        470        480
AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA
       490        500        510        520        530        540
AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE
       550        560        570
DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII         10         20         30         40         50         60
MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL
        70         80         90        100        110        120
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER
       130        140        150        160        170        180
SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE
       190        200        210        220        230        240
IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL
       250        260        270        280        290        300
REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE
       310        320        330        340        350        360
ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK
       370        380        390        400        410        420
LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR
       430        440        450        460        470        480
AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA
       490        500        510        520        530        540
AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE
       550        560        570
DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII         10         20         30         40         50         60
MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL
        70         80         90        100        110        120
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER
       130        140        150        160        170        180
SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE
       190        200        210        220        230        240
IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL
       250        260        270        280        290        300
REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE
       310        320        330        340        350        360
ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK
       370        380        390        400        410        420
LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR
       430        440        450        460        470        480
AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA
       490        500        510        520        530        540
AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE
       550        560        570
DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII         10         20         30         40         50         60
MSHQPLSCLT EKEDSPSEST GNGPPHLAHP NLDTFTPEEL LQQMKELLTE NHQLKEAMKL
        70         80         90        100        110        120
NNQAMKGRFE ELSAWTEKQK EERQFFEIQS KEAKERLMAL SHENEKLKEE LGKLKGKSER
       130        140        150        160        170        180
SSEDPTDDSR LPRAEAEQEK DQLRTQVVRL QAEKADLLGI VSELQLKLNS SGSSEDSFVE
       190        200        210        220        230        240
IRMAEGEAEG SVKEIKHSPG PTRTVSTGTA LSKYRSRSAD GAKNYFEHEE LTVSQLLLCL
       250        260        270        280        290        300
REGNQKVERL EVALKEAKER VSDFEKKTSN RSEIETQTEG STEKENDEEK GPETVGSEVE
       310        320        330        340        350        360
ALNLQVTSLF KELQEAHTKL SEAELMKKRL QEKCQALERK NSAIPSELNE KQELVYTNKK
       370        380        390        400        410        420
LELQVESMLS EIKMEQAKTE DEKSKLTVLQ MTHNKLLQEH NNALKTIEEL TRKESEKVDR
       430        440        450        460        470        480
AVLKELSEKL ELAEKALASK QLQMDEMKQT IAKQEEDLET MTILRAQMEV YCSDFHAERA
       490        500        510        520        530        540
AREKIHEEKE QLALQLAVLL KENDAFEDGG RQSLMEMQSR HGARTSDSDQ QAYLVQRGAE
       550        560        570
DRDWRQQRNI PIHSCPKCGE VLPDIDTLQI HVMDCII

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q96CV9-1-unknown	MSHQPL...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q96CV9-1-unknown	MSHQPL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83815
Q96CV9-58-unknown	MKLNNQ...	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt83816
Q96CV9-58-unknown	MKLNNQ...	58	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101813

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...MDCII	577	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...MDCII	577	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79434
...MDCII	577	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt79433

TopFIND

Q96CV9: Optineurin

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

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Protease Assignment Confidence:

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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates