TopFIND 4.0

Q96G25: Mediator of RNA polymerase II transcription subunit 8

General Information

Protein names
- Mediator of RNA polymerase II transcription subunit 8
- Activator-recruited cofactor 32 kDa component
- ARC32
- Mediator complex subunit 8
Gene names MED8
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q96G25

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQREEKQLEA SLDALLSQVA DLKNSLGSFI CKLENEYGRL TWPSVLDSFA LLSGQLNTLN 
        70         80         90        100        110        120 
KVLKHEKTPL FRNQVIIPLV LSPDRDEDLM RQTEGRVPVF SHEVVPDHLR TKPDPEVEEQ 
       130        140        150        160        170        180 
EKQLTTDAAR IGADAAQKQI QSLNKMCSNL LEKISKEERE SESGGLRPNK QTFNPTDTNA 
       190        200        210        220        230        240 
LVAAVAFGKG LSNWRPSGSS GPGQAGQPGA GTILAGTSGL QQVQMAGAPS QQQPMLSGVQ 
       250        260    
MAQAGQPGKM PSGIKTNIKS ASMHPYQR

Isoforms

- Isoform 2 of Mediator of RNA polymerase II transcription subunit 8 - Isoform 3 of Mediator of RNA polymerase II transcription subunit 8

Sequence View

        10         20         30         40         50         60 
MQREEKQLEA SLDALLSQVA DLKNSLGSFI CKLENEYGRL TWPSVLDSFA LLSGQLNTLN 
        70         80         90        100        110        120 
KVLKHEKTPL FRNQVIIPLV LSPDRDEDLM RQTEGRVPVF SHEVVPDHLR TKPDPEVEEQ 
       130        140        150        160        170        180 
EKQLTTDAAR IGADAAQKQI QSLNKMCSNL LEKISKEERE SESGGLRPNK QTFNPTDTNA 
       190        200        210        220        230        240 
LVAAVAFGKG LSNWRPSGSS GPGQAGQPGA GTILAGTSGL QQVQMAGAPS QQQPMLSGVQ 
       250        260    
MAQAGQPGKM PSGIKTNIKS ASMHPYQR         10         20         30         40         50         60 
MQREEKQLEA SLDALLSQVA DLKNSLGSFI CKLENEYGRL TWPSVLDSFA LLSGQLNTLN 
        70         80         90        100        110        120 
KVLKHEKTPL FRNQVIIPLV LSPDRDEDLM RQTEGRVPVF SHEVVPDHLR TKPDPEVEEQ 
       130        140        150        160        170        180 
EKQLTTDAAR IGADAAQKQI QSLNKMCSNL LEKISKEERE SESGGLRPNK QTFNPTDTNA 
       190        200        210        220        230        240 
LVAAVAFGKG LSNWRPSGSS GPGQAGQPGA GTILAGTSGL QQVQMAGAPS QQQPMLSGVQ 
       250        260    
MAQAGQPGKM PSGIKTNIKS ASMHPYQR



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Physiological Relevance:


Evidence Codes:


Methodology:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)