TopFIND 4.0

Q96JA3: Pleckstrin homology domain-containing family A member 8

General Information

Protein names
- Pleckstrin homology domain-containing family A member 8
- PH domain-containing family A member 8
- Phosphatidylinositol-four-phosphate adapter protein 2
- FAPP-2
- Phosphoinositol 4-phosphate adapter protein 2
- hFAPP2
- Serologically defined breast cancer antigen NY-BR-86
Gene names PLEKHA8
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q96JA3

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR 
        70         80         90        100        110        120 
MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL 
       130        140        150        160        170        180 
RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE 
       190        200        210        220        230        240 
LLYRTPPGSP QLAMLKSSKM KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK 
       250        260        270        280        290        300 
NSLYLKSAEI DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL 
       310        320        330        340        350        360 
WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD 
       370        380        390        400        410        420 
LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT 
       430        440        450        460        470        480 
EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TVKEGDHQKE 
       490        500        510    
AFSIGMQRDL SLYLPAMEKQ LAILDTLYEV HGLESDEVV

Isoforms

- Isoform 2 of Pleckstrin homology domain-containing family A member 8 - Isoform 3 of Pleckstrin homology domain-containing family A member 8

Sequence View

        10         20         30         40         50         60 
MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR 
        70         80         90        100        110        120 
MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL 
       130        140        150        160        170        180 
RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE 
       190        200        210        220        230        240 
LLYRTPPGSP QLAMLKSSKM KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK 
       250        260        270        280        290        300 
NSLYLKSAEI DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL 
       310        320        330        340        350        360 
WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD 
       370        380        390        400        410        420 
LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT 
       430        440        450        460        470        480 
EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TVKEGDHQKE 
       490        500        510    
AFSIGMQRDL SLYLPAMEKQ LAILDTLYEV HGLESDEVV         10         20         30         40         50         60 
MEGVLYKWTN YLSGWQPRWF LLCGGILSYY DSPEDAWKGC KGSIQMAVCE IQVHSVDNTR 
        70         80         90        100        110        120 
MDLIIPGEQY FYLKARSVAE RQRWLVALGS AKACLTDSRT QKEKEFAENT ENLKTKMSEL 
       130        140        150        160        170        180 
RLYCDLLVQQ VDKTKEVTTT GVSNSEEGID VGTLLKSTCN TFLKTLEECM QIANAAFTSE 
       190        200        210        220        230        240 
LLYRTPPGSP QLAMLKSSKM KHPIIPIHNS LERQMELSTC ENGSLNMEIN GEEEILMKNK 
       250        260        270        280        290        300 
NSLYLKSAEI DCSISSEENT DDNITVQGEI RKEDGMENLK NHDNNLTQSG SDSSCSPECL 
       310        320        330        340        350        360 
WEEGKEVIPT FFSTMNTSFS DIELLEDSGI PTEAFLASCY AVVPVLDKLG PTVFAPVKMD 
       370        380        390        400        410        420 
LVGNIKKVNQ KYITNKEEFT TLQKIVLHEV EADVAQVRNS ATEALLWLKR GLKFLKGFLT 
       430        440        450        460        470        480 
EVKNGEKDIQ TALNNAYGKT LRQHHGWVVR GVFALALRAA PSYEDFVAAL TVKEGDHQKE 
       490        500        510    
AFSIGMQRDL SLYLPAMEKQ LAILDTLYEV HGLESDEVV



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q96JA3-1-unknown MEGVLY... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q96JA3-1-unknown MEGVLY... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85371
    Q96JA3-1-unknown MEGVLY... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt85372

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...SDEVV 519 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)