TopFIND 4.0

Q96LW4: DNA-directed primase/polymerase protein

General Information

Protein names
- DNA-directed primase/polymerase protein
- hPrimpol1
- 2.7.7.-
- Coiled-coil domain-containing protein 111
Gene names PRIMPOL
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q96LW4

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MNRKWEAKLK QIEERASHYE RKPLSSVYRP RLSKPEEPPS IWRLFHRQAQ AFNFVKSCKE 
        70         80         90        100        110        120 
DVHVFALECK VGDGQRIYLV TTYAEFWFYY KSRKNLLHCY EVIPENAVCK LYFDLEFNKP 
       130        140        150        160        170        180 
ANPGADGKKM VALLIEYVCK ALQELYGVNC SAEDVLNLDS STDEKFSRHL IFQLHDVAFK 
       190        200        210        220        230        240 
DNIHVGNFLR KILQPALDLL GSEDDDSAPE TTGHGFPHFS EAPARQGFSF NKMFTEKATE 
       250        260        270        280        290        300 
ESWTSNSKKL ERLGSAEQSS PDLSFLVVKN NMGEKHLFVD LGVYTRNRNF RLYKSSKIGK 
       310        320        330        340        350        360 
RVALEVTEDN KFFPIQSKDV SDEYQYFLSS LVSNVRFSDT LRILTCEPSQ NKQKGVGYFN 
       370        380        390        400        410        420 
SIGTSVETIE GFQCSPYPEV DHFVLSLVNK DGIKGGIRRW NYFFPEELLV YDICKYRWCE 
       430        440        450        460        470        480 
NIGRAHKSNN IMILVDLKNE VWYQKCHDPV CKAENFKSDC FPLPAEVCLL FLFKEEEEFT 
       490        500        510        520        530        540 
TDEADETRSN ETQNPHKPSP SRLSTGASAD AVWDNGIDDA YFLEATEDAE LAEAAENSLL 
       550        560    
SYNSEVDEIP DELIIEVLQE 

Isoforms

- Isoform 2 of DNA-directed primase/polymerase protein - Isoform 2 of DNA-directed primase/polymerase protein

Sequence View

        10         20         30         40         50         60 
MNRKWEAKLK QIEERASHYE RKPLSSVYRP RLSKPEEPPS IWRLFHRQAQ AFNFVKSCKE 
        70         80         90        100        110        120 
DVHVFALECK VGDGQRIYLV TTYAEFWFYY KSRKNLLHCY EVIPENAVCK LYFDLEFNKP 
       130        140        150        160        170        180 
ANPGADGKKM VALLIEYVCK ALQELYGVNC SAEDVLNLDS STDEKFSRHL IFQLHDVAFK 
       190        200        210        220        230        240 
DNIHVGNFLR KILQPALDLL GSEDDDSAPE TTGHGFPHFS EAPARQGFSF NKMFTEKATE 
       250        260        270        280        290        300 
ESWTSNSKKL ERLGSAEQSS PDLSFLVVKN NMGEKHLFVD LGVYTRNRNF RLYKSSKIGK 
       310        320        330        340        350        360 
RVALEVTEDN KFFPIQSKDV SDEYQYFLSS LVSNVRFSDT LRILTCEPSQ NKQKGVGYFN 
       370        380        390        400        410        420 
SIGTSVETIE GFQCSPYPEV DHFVLSLVNK DGIKGGIRRW NYFFPEELLV YDICKYRWCE 
       430        440        450        460        470        480 
NIGRAHKSNN IMILVDLKNE VWYQKCHDPV CKAENFKSDC FPLPAEVCLL FLFKEEEEFT 
       490        500        510        520        530        540 
TDEADETRSN ETQNPHKPSP SRLSTGASAD AVWDNGIDDA YFLEATEDAE LAEAAENSLL 
       550        560    
SYNSEVDEIP DELIIEVLQE          10         20         30         40         50         60 
MNRKWEAKLK QIEERASHYE RKPLSSVYRP RLSKPEEPPS IWRLFHRQAQ AFNFVKSCKE 
        70         80         90        100        110        120 
DVHVFALECK VGDGQRIYLV TTYAEFWFYY KSRKNLLHCY EVIPENAVCK LYFDLEFNKP 
       130        140        150        160        170        180 
ANPGADGKKM VALLIEYVCK ALQELYGVNC SAEDVLNLDS STDEKFSRHL IFQLHDVAFK 
       190        200        210        220        230        240 
DNIHVGNFLR KILQPALDLL GSEDDDSAPE TTGHGFPHFS EAPARQGFSF NKMFTEKATE 
       250        260        270        280        290        300 
ESWTSNSKKL ERLGSAEQSS PDLSFLVVKN NMGEKHLFVD LGVYTRNRNF RLYKSSKIGK 
       310        320        330        340        350        360 
RVALEVTEDN KFFPIQSKDV SDEYQYFLSS LVSNVRFSDT LRILTCEPSQ NKQKGVGYFN 
       370        380        390        400        410        420 
SIGTSVETIE GFQCSPYPEV DHFVLSLVNK DGIKGGIRRW NYFFPEELLV YDICKYRWCE 
       430        440        450        460        470        480 
NIGRAHKSNN IMILVDLKNE VWYQKCHDPV CKAENFKSDC FPLPAEVCLL FLFKEEEEFT 
       490        500        510        520        530        540 
TDEADETRSN ETQNPHKPSP SRLSTGASAD AVWDNGIDDA YFLEATEDAE LAEAAENSLL 
       550        560    
SYNSEVDEIP DELIIEVLQE 



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q96LW4-1-unknown MNRKWE... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q96LW4-1-unknown MNRKWE... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt86202

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EVLQE 560 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EVLQE 560 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt81820

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)