Q96RR1: Twinkle protein, mitochondrial {ECO:0000305}
Protein names | - Twinkle protein, mitochondrial {ECO:0000305} - 3.6.4.12 - Progressive external ophthalmoplegia 1 protein - T7 gp4-like protein with intramitochondrial nucleoid localization - T7-like mitochondrial DNA helicase - Twinkle mtDNA helicase {ECO:0000312|HGNC:HGNC:1160} |
---|---|
Gene names | PEO1 |
Organism | Homo sapiens |
Protease Family | |
Protease ID | |
Chromosome location | |
UniProt ID | Q96RR1 |
2
N-termini
2
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MWVLLRSGYP LRILLPLRGE WMGRRGLPRN LAPGPPRRRY RKETLQALDM PVLPVTATEI
70 80 90 100 110 120
RQYLRGHGIP FQDGHSCLRA LSPFAESSQL KGQTGVTTSF SLFIDKTTGH FLCMTSLAEG
130 140 150 160 170 180
SWEDFQASVE GRGDGAREGF LLSKAPEFED SEEVRRIWNR AIPLWELPDQ EEVQLADTMF
190 200 210 220 230 240
GLTKVTDDTL KRFSVRYLRP ARSLVFPWFS PGGSGLRGLK LLEAKCQGDG VSYEETTIPR
250 260 270 280 290 300
PSAYHNLFGL PLISRRDAEV VLTSRELDSL ALNQSTGLPT LTLPRGTTCL PPALLPYLEQ
310 320 330 340 350 360
FRRIVFWLGD DLRSWEAAKL FARKLNPKRC FLVRPGDQQP RPLEALNGGF NLSRILRTAL
370 380 390 400 410 420
PAWHKSIVSF RQLREEVLGE LSNVEQAAGL RWSRFPDLNR ILKGHRKGEL TVFTGPTGSG
430 440 450 460 470 480
KTTFISEYAL DLCSQGVNTL WGSFEISNVR LARVMLTQFA EGRLEDQLDK YDHWADRFED
490 500 510 520 530 540
LPLYFMTFHG QQSIRTVIDT MQHAVYVYDI CHVIIDNLQF MMGHEQLSTD RIAAQDYIIG
550 560 570 580 590 600
VFRKFATDNN CHVTLVIHPR KEDDDKELQT ASIFGSAKAS QEADNVLILQ DRKLVTGPGK
610 620 630 640 650 660
RYLQVSKNRF DGDVGVFPLE FNKNSLTFSI PPKNKARLKK IKDDTGPVAK KPSSGKKGAT
670 680
TQNSEICSGQ APTPDQPDTS KRSK
Isoforms
- Isoform 2 of Twinkle protein, mitochondrial - Isoform 3 of Twinkle protein, mitochondrialSequence View
10 20 30 40 50 60
MWVLLRSGYP LRILLPLRGE WMGRRGLPRN LAPGPPRRRY RKETLQALDM PVLPVTATEI
70 80 90 100 110 120
RQYLRGHGIP FQDGHSCLRA LSPFAESSQL KGQTGVTTSF SLFIDKTTGH FLCMTSLAEG
130 140 150 160 170 180
SWEDFQASVE GRGDGAREGF LLSKAPEFED SEEVRRIWNR AIPLWELPDQ EEVQLADTMF
190 200 210 220 230 240
GLTKVTDDTL KRFSVRYLRP ARSLVFPWFS PGGSGLRGLK LLEAKCQGDG VSYEETTIPR
250 260 270 280 290 300
PSAYHNLFGL PLISRRDAEV VLTSRELDSL ALNQSTGLPT LTLPRGTTCL PPALLPYLEQ
310 320 330 340 350 360
FRRIVFWLGD DLRSWEAAKL FARKLNPKRC FLVRPGDQQP RPLEALNGGF NLSRILRTAL
370 380 390 400 410 420
PAWHKSIVSF RQLREEVLGE LSNVEQAAGL RWSRFPDLNR ILKGHRKGEL TVFTGPTGSG
430 440 450 460 470 480
KTTFISEYAL DLCSQGVNTL WGSFEISNVR LARVMLTQFA EGRLEDQLDK YDHWADRFED
490 500 510 520 530 540
LPLYFMTFHG QQSIRTVIDT MQHAVYVYDI CHVIIDNLQF MMGHEQLSTD RIAAQDYIIG
550 560 570 580 590 600
VFRKFATDNN CHVTLVIHPR KEDDDKELQT ASIFGSAKAS QEADNVLILQ DRKLVTGPGK
610 620 630 640 650 660
RYLQVSKNRF DGDVGVFPLE FNKNSLTFSI PPKNKARLKK IKDDTGPVAK KPSSGKKGAT
670 680
TQNSEICSGQ APTPDQPDTS KRSK
10 20 30 40 50 60
MWVLLRSGYP LRILLPLRGE WMGRRGLPRN LAPGPPRRRY RKETLQALDM PVLPVTATEI
70 80 90 100 110 120
RQYLRGHGIP FQDGHSCLRA LSPFAESSQL KGQTGVTTSF SLFIDKTTGH FLCMTSLAEG
130 140 150 160 170 180
SWEDFQASVE GRGDGAREGF LLSKAPEFED SEEVRRIWNR AIPLWELPDQ EEVQLADTMF
190 200 210 220 230 240
GLTKVTDDTL KRFSVRYLRP ARSLVFPWFS PGGSGLRGLK LLEAKCQGDG VSYEETTIPR
250 260 270 280 290 300
PSAYHNLFGL PLISRRDAEV VLTSRELDSL ALNQSTGLPT LTLPRGTTCL PPALLPYLEQ
310 320 330 340 350 360
FRRIVFWLGD DLRSWEAAKL FARKLNPKRC FLVRPGDQQP RPLEALNGGF NLSRILRTAL
370 380 390 400 410 420
PAWHKSIVSF RQLREEVLGE LSNVEQAAGL RWSRFPDLNR ILKGHRKGEL TVFTGPTGSG
430 440 450 460 470 480
KTTFISEYAL DLCSQGVNTL WGSFEISNVR LARVMLTQFA EGRLEDQLDK YDHWADRFED
490 500 510 520 530 540
LPLYFMTFHG QQSIRTVIDT MQHAVYVYDI CHVIIDNLQF MMGHEQLSTD RIAAQDYIIG
550 560 570 580 590 600
VFRKFATDNN CHVTLVIHPR KEDDDKELQT ASIFGSAKAS QEADNVLILQ DRKLVTGPGK
610 620 630 640 650 660
RYLQVSKNRF DGDVGVFPLE FNKNSLTFSI PPKNKARLKK IKDDTGPVAK KPSSGKKGAT
670 680
TQNSEICSGQ APTPDQPDTS KRSK
Protein Neighborhood
Domains & Features
2 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates
N-termini
Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
---|---|---|---|---|---|---|---|---|---|
Q96RR1-1-unknown | MWVLLR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt84863 | |||
Q96RR1-1-unknown | MWVLLR... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt84864 | |||
Q96RR1-32-unknown | APGPPR... | 32 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
Q96RR1-32-unknown | APGPPR... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114962 | |||
Q96RR1-32-unknown | APGPPR... | 32 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt114963 |
C-termini
Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|---|---|---|---|---|---|---|---|
...LSTDRI | 531 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt80482 | |||
...LSTDRI | 531 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt93015 | |||
...SKRSK | 684 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
---|
Substrates
Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
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