Q96RR4: Calcium/calmodulin-dependent protein kinase kinase 2

General Information

Protein names	- Calcium/calmodulin-dependent protein kinase kinase 2 - CaM-KK 2 - CaM-kinase kinase 2 - CaMKK 2 - 2.7.11.17 - Calcium/calmodulin-dependent protein kinase kinase beta - CaM-KK beta - CaM-kinase kinase beta - CaMKK beta
Gene names	CAMKK2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96RR4

5 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Calcium/calmodulin-dependent protein kinase kinase 2 - Isoform 3 of Calcium/calmodulin-dependent protein kinase kinase 2 - Isoform 4 of Calcium/calmodulin-dependent protein kinase kinase 2 - Isoform 5 of Calcium/calmodulin-dependent protein kinase kinase 2 - Isoform 6 of Calcium/calmodulin-dependent protein kinase kinase 2 - Isoform 7 of Calcium/calmodulin-dependent protein kinase kinase 2

Sequence View

        10         20         30         40         50         60
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP
        70         80         90        100        110        120
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR
       130        140        150        160        170        180
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK
       190        200        210        220        230        240
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL
       250        260        270        280        290        300
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
       310        320        330        340        350        360
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS
       370        380        390        400        410        420
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK
       430        440        450        460        470        480
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS
       490        500        510        520        530        540
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP
       550        560        570        580
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE         10         20         30         40         50         60
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP
        70         80         90        100        110        120
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR
       130        140        150        160        170        180
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK
       190        200        210        220        230        240
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL
       250        260        270        280        290        300
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
       310        320        330        340        350        360
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS
       370        380        390        400        410        420
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK
       430        440        450        460        470        480
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS
       490        500        510        520        530        540
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP
       550        560        570        580
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE         10         20         30         40         50         60
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP
        70         80         90        100        110        120
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR
       130        140        150        160        170        180
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK
       190        200        210        220        230        240
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL
       250        260        270        280        290        300
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
       310        320        330        340        350        360
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS
       370        380        390        400        410        420
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK
       430        440        450        460        470        480
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS
       490        500        510        520        530        540
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP
       550        560        570        580
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE         10         20         30         40         50         60
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP
        70         80         90        100        110        120
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR
       130        140        150        160        170        180
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK
       190        200        210        220        230        240
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL
       250        260        270        280        290        300
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
       310        320        330        340        350        360
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS
       370        380        390        400        410        420
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK
       430        440        450        460        470        480
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS
       490        500        510        520        530        540
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP
       550        560        570        580
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE         10         20         30         40         50         60
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP
        70         80         90        100        110        120
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR
       130        140        150        160        170        180
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK
       190        200        210        220        230        240
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL
       250        260        270        280        290        300
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
       310        320        330        340        350        360
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS
       370        380        390        400        410        420
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK
       430        440        450        460        470        480
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS
       490        500        510        520        530        540
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP
       550        560        570        580
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE         10         20         30         40         50         60
MSSCVSSQPS SNRAAPQDEL GGRGSSSSES QKPCEALRGL SSLSIHLGME SFIVVTECEP
        70         80         90        100        110        120
GCAVDLGLAR DRPLEADGQE VPLDTSGSQA RPHLSGRKLS LQERSQGGLA AGGSLDMNGR
       130        140        150        160        170        180
CICPSLPYSP VSSPQSSPRL PRRPTVESHH VSITGMQDCV QLNQYTLKDE IGKGSYGVVK
       190        200        210        220        230        240
LAYNENDNTY YAMKVLSKKK LIRQAGFPRR PPPRGTRPAP GGCIQPRGPI EQVYQEIAIL
       250        260        270        280        290        300
KKLDHPNVVK LVEVLDDPNE DHLYMVFELV NQGPVMEVPT LKPLSEDQAR FYFQDLIKGI
       310        320        330        340        350        360
EYLHYQKIIH RDIKPSNLLV GEDGHIKIAD FGVSNEFKGS DALLSNTVGT PAFMAPESLS
       370        380        390        400        410        420
ETRKIFSGKA LDVWAMGVTL YCFVFGQCPF MDERIMCLHS KIKSQALEFP DQPDIAEDLK
       430        440        450        460        470        480
DLITRMLDKN PESRIVVPEI KLHPWVTRHG AEPLPSEDEN CTLVEVTEEE VENSVKHIPS
       490        500        510        520        530        540
LATVILVKTM IRKRSFGNPF EGSRREERSL SAPGNLLTKK PTRECESLSE LKEARQRRQP
       550        560        570        580
PGHRPAPRGG GGSALVRGSP CVESCWAPAP GSPARMHPLR PEEAMEPE

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

5 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96RR4-1-unknown	MSSCVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79034
Q96RR4-1-unknown	MSSCVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79035
Q96RR4-1-unknown	MSSCVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79036
Q96RR4-1-unknown	MSSCVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79037
Q96RR4-1-unknown	MSSCVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79038
Q96RR4-1-unknown	MSSCVS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt79039
Q96RR4-2-unknown	MSSCVS...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111331
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111332
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111333
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111334
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111335
Q96RR4-2-Acetylation	SSCVSS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111336
Q96RR4-562-	VESCWA...	562			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q96RR4-562-unknown	VESCWA...	562		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt176437

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...AMEPE	588	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...AMEPE	588	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt74654

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)