Q96S66: Chloride channel CLIC-like protein 1

General Information

Protein names	- Chloride channel CLIC-like protein 1 - Mid-1-related chloride channel protein 1
Gene names	CLCC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96S66

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Chloride channel CLIC-like protein 1 - Isoform 3 of Chloride channel CLIC-like protein 1 - Isoform 4 of Chloride channel CLIC-like protein 1

Sequence View

        10         20         30         40         50         60
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG EKDVSPDLSC
        70         80         90        100        110        120
ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY LNKILIEAGK LGLPDENKGD
       130        140        150        160        170        180
MHYDAEIILK RETLLEIQKF LNGEDWKPGA LDDALSDILI NFKFHDFETW KWRFEDSFGV
       190        200        210        220        230        240
DPYNVLMVLL CLLCIVVLVA TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH
       250        260        270        280        290        300
QAEVAKMEPL NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
       310        320        330        340        350        360
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC YGAGKSVHVL
       370        380        390        400        410        420
RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY RGQMGPTEQG PYAKTYEGRR
       430        440        450        460        470        480
EILRERDVDL RFQTGNKSPE VLRAFDVPDA EAREHPTVVP SHKSPVLDTK PKETGGILGE
       490        500        510        520        530        540
GTPKESSTES SQSAKPVSGQ DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP
       550
RGQDPVSSPC G         10         20         30         40         50         60
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG EKDVSPDLSC
        70         80         90        100        110        120
ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY LNKILIEAGK LGLPDENKGD
       130        140        150        160        170        180
MHYDAEIILK RETLLEIQKF LNGEDWKPGA LDDALSDILI NFKFHDFETW KWRFEDSFGV
       190        200        210        220        230        240
DPYNVLMVLL CLLCIVVLVA TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH
       250        260        270        280        290        300
QAEVAKMEPL NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
       310        320        330        340        350        360
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC YGAGKSVHVL
       370        380        390        400        410        420
RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY RGQMGPTEQG PYAKTYEGRR
       430        440        450        460        470        480
EILRERDVDL RFQTGNKSPE VLRAFDVPDA EAREHPTVVP SHKSPVLDTK PKETGGILGE
       490        500        510        520        530        540
GTPKESSTES SQSAKPVSGQ DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP
       550
RGQDPVSSPC G         10         20         30         40         50         60
MLCSLLLCEC LLLVAGYAHD DDWIDPTDML NYDAASGTMR KSQAKYGISG EKDVSPDLSC
        70         80         90        100        110        120
ADEISECYHK LDSLTYKIDE CEKKKREDYE SQSNPVFRRY LNKILIEAGK LGLPDENKGD
       130        140        150        160        170        180
MHYDAEIILK RETLLEIQKF LNGEDWKPGA LDDALSDILI NFKFHDFETW KWRFEDSFGV
       190        200        210        220        230        240
DPYNVLMVLL CLLCIVVLVA TELWTYVRWY TQLRRVLIIS FLFSLGWNWM YLYKLAFAQH
       250        260        270        280        290        300
QAEVAKMEPL NNVCAKKMDW TGSIWEWFRS SWTYKDDPCQ KYYELLLVNP IWLVPPTKAL
       310        320        330        340        350        360
AVTFTTFVTE PLKHIGKGTG EFIKALMKEI PALLHLPVLI IMALAILSFC YGAGKSVHVL
       370        380        390        400        410        420
RHIGGPESEP PQALRPRDRR RQEEIDYRPD GGAGDADFHY RGQMGPTEQG PYAKTYEGRR
       430        440        450        460        470        480
EILRERDVDL RFQTGNKSPE VLRAFDVPDA EAREHPTVVP SHKSPVLDTK PKETGGILGE
       490        500        510        520        530        540
GTPKESSTES SQSAKPVSGQ DTSGNTEGSP AAEKAQLKSE AAGSPDQGST YSPARGVAGP
       550
RGQDPVSSPC G

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q96S66-1-unknown	MLCSLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70912
Q96S66-1-unknown	MLCSLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70913
Q96S66-1-unknown	MLCSLL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt70911
Q96S66-19-unknown	HDDDWI...	19	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q96S66-19-unknown	HDDDWI...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112121
Q96S66-19-unknown	HDDDWI...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112122
Q96S66-19-unknown	HDDDWI...	19	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt112123
Q96S66-391-unknown	GGAGDA...	391	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC1343
Q96S66-391-unknown	GGAGDA...	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146749
Q96S66-391-unknown	GGAGDA...	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149114
Q96S66-391-unknown	GGAGDA...	391	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt150753

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DYRPDG	390	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1343
...DYRPDG	390	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt130060
...DYRPDG	390	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt132499
...DYRPDG	390	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt134153
...SSPCG	551		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SSPCG	551	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SSPCG	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66531
...SSPCG	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66530
...SSPCG	551	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66529
...SSPCG	551		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	390	RPDG.\|.GGAG	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)