TopFIND 4.0

Q96SW2: Protein cereblon

General Information

Protein names
- Protein cereblon
Gene names CRBN
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q96SW2

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL 
        70         80         90        100        110        120 
GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF 
       130        140        150        160        170        180 
AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA 
       190        200        210        220        230        240 
KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW 
       250        260        270        280        290        300 
PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK 
       310        320        330        340        350        360 
IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL 
       370        380        390        400        410        420 
TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS 
       430        440    
ALLPTIPDTE DEISPDKVIL CL

Isoforms

- Isoform 2 of Protein cereblon

Sequence View

        10         20         30         40         50         60 
MAGEGDQQDA AHNMGNHLPL LPAESEEEDE MEVEDQDSKE AKKPNIINFD TSLPTSHTYL 
        70         80         90        100        110        120 
GADMEEFHGR TLHDDDSCQV IPVLPQVMMI LIPGQTLPLQ LFHPQEVSMV RNLIQKDRTF 
       130        140        150        160        170        180 
AVLAYSNVQE REAQFGTTAE IYAYREEQDF GIEIVKVKAI GRQRFKVLEL RTQSDGIQQA 
       190        200        210        220        230        240 
KVQILPECVL PSTMSAVQLE SLNKCQIFPS KPVSREDQCS YKWWQKYQKR KFHCANLTSW 
       250        260        270        280        290        300 
PRWLYSLYDA ETLMDRIKKQ LREWDENLKD DSLPSNPIDF SYRVAACLPI DDVLRIQLLK 
       310        320        330        340        350        360 
IGSAIQRLRC ELDIMNKCTS LCCKQCQETE ITTKNEIFSL SLCGPMAAYV NPHGYVHETL 
       370        380        390        400        410        420 
TVYKACNLNL IGRPSTEHSW FPGYAWTVAQ CKICASHIGW KFTATKKDMS PQKFWGLTRS 
       430        440    
ALLPTIPDTE DEISPDKVIL CL



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Evidence Codes:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q96SW2-1-unknown MAGEGD... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q96SW2-1-unknown MAGEGD... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt71647
    Q96SW2-10- AAHNMG... 10 Subtiligase Based Positive Selection Wells apoptotic_MM1s_bort 23264352

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...VILCL 442 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...VILCL 442 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt67265

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)