Q96T60: Bifunctional polynucleotide phosphatase/kinase

General Information

Protein names	- Bifunctional polynucleotide phosphatase/kinase - DNA 5'-kinase/3'-phosphatase - Polynucleotide kinase-3'-phosphatase - Polynucleotide 3'-phosphatase - 3.1.3.32 - 2'(3')-polynucleotidase - Polynucleotide 5'-hydroxyl-kinase - 2.7.1.78
Gene names	PNKP
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q96T60

2 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MGEVEAPGRL WLESPPGGAP PIFLPSDGQA LVLGRGPLTQ VTDRKCSRTQ VELVADPETR
        70         80         90        100        110        120
TVAVKQLGVN PSTTGTQELK PGLEGSLGVG DTLYLVNGLH PLTLRWEETR TPESQPDTPP
       130        140        150        160        170        180
GTPLVSQDEK RDAELPKKRM RKSNPGWENL EKLLVFTAAG VKPQGKVAGF DLDGTLITTR
       190        200        210        220        230        240
SGKVFPTGPS DWRILYPEIP RKLRELEAEG YKLVIFTNQM SIGRGKLPAE EFKAKVEAVV
       250        260        270        280        290        300
EKLGVPFQVL VATHAGLYRK PVTGMWDHLQ EQANDGTPIS IGDSIFVGDA AGRPANWAPG
       310        320        330        340        350        360
RKKKDFSCAD RLFALNLGLP FATPEEFFLK WPAAGFELPA FDPRTVSRSG PLCLPESRAL
       370        380        390        400        410        420
LSASPEVVVA VGFPGAGKST FLKKHLVSAG YVHVNRDTLG SWQRCVTTCE TALKQGKRVA
       430        440        450        460        470        480
IDNTNPDAAS RARYVQCARA AGVPCRCFLF TATLEQARHN NRFREMTDSS HIPVSDMVMY
       490        500        510        520
GYRKQFEAPT LAEGFSAILE IPFRLWVEPR LGRLYCQFSE G

Isoforms

- Isoform 2 of Bifunctional polynucleotide phosphatase/kinase

Sequence View

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Protein Neighborhood

Domains & Features

2 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q96T60-1-Acetylation	MGEVEA...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q96T60-1-Acetylation	MGEVEA...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q96T60-2-acetylation	GEVEAP...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SDGQAL	30	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000470887
...VAVKQL	66	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000469848
...QFSEG	521		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...QFSEG	521	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...QFSEG	521		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)