Q99217: Amelogenin, X isoform

General Information

Protein names	- Amelogenin, X isoform
Gene names	AMELX
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99217

9 N-termini

8 C-termini

7 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Amelogenin, X isoform - Isoform 3 of Amelogenin, X isoform

Sequence View

        10         20         30         40         50         60
MGTWILFACL LGAAFAMPLP PHPGHPGYIN FSYEVLTPLK WYQSIRPPYP SYGYEPMGGW
        70         80         90        100        110        120
LHHQIIPVLS QQHPPTHTLQ PHHHIPVVPA QQPVIPQQPM MPVPGQHSMT PIQHHQPNLP
       130        140        150        160        170        180
PPAQQPYQPQ PVQPQPHQPM QPQPPVHPMQ PLPPQPPLPP MFPMQPLPPM LPDLTLEAWP
       190
STDKTKREEV D         10         20         30         40         50         60
MGTWILFACL LGAAFAMPLP PHPGHPGYIN FSYEVLTPLK WYQSIRPPYP SYGYEPMGGW
        70         80         90        100        110        120
LHHQIIPVLS QQHPPTHTLQ PHHHIPVVPA QQPVIPQQPM MPVPGQHSMT PIQHHQPNLP
       130        140        150        160        170        180
PPAQQPYQPQ PVQPQPHQPM QPQPPVHPMQ PLPPQPPLPP MFPMQPLPPM LPDLTLEAWP
       190
STDKTKREEV D

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

9 N-termini - 8 C-termini - 7 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99217-1-unknown	MGTWIL...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66789
Q99217-17-unknown	MPLPPH...	17	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99217-34-unknown	EVLTPL...	34	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21805
Q99217-61-unknown	LHHQII...	61	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21806
Q99217-61-unknown	LHHQII...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt138714
Q99217-61-unknown	LHHQII...	61	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt140954
Q99217-164-unknown	MQPLPP...	164	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21809
Q99217-164-unknown	MQPLPP...	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt144628
Q99217-164-unknown	MQPLPP...	164	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145820
Q99217-173-unknown	DLTLEA...	173	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21812
Q99217-173-unknown	DLTLEA...	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145021
Q99217-173-unknown	DLTLEA...	173	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146139
Q99217-176-unknown	LEAWPS...	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21815
Q99217-176-unknown	LEAWPS...	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145129
Q99217-176-unknown	LEAWPS...	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146243
Q99217-177-unknown	EAWPST...	177	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21818
Q99217-177-unknown	EAWPST...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145178
Q99217-177-unknown	EAWPST...	177	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146274
Q99217-181-unknown	STDKTK...	181	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21821
Q99217-181-unknown	STDKTK...	181	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt145333
Q99217-181-unknown	STDKTK...	181	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt146422

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...INFSYE	33	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21805
...INFSYE	33	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153767
...PMGGWL	60	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21806
...PMGGWL	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt121768
...PMGGWL	60	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt124101
...PPMFPM	163	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21809
...PPMFPM	163	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt127895
...PPMFPM	163	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129117
...PPMLPD	172	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21812
...PPMLPD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128300
...PPMLPD	172	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129441
...LPDLTL	175	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21815
...LPDLTL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128415
...LPDLTL	175	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129547
...PDLTLE	176	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21818
...PDLTLE	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128466
...PDLTLE	176	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129579
...LEAWPS	180	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC21821
...LEAWPS	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt128624
...LEAWPS	180	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt129727
...REEVD	191	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...REEVD	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62406
...REEVD	191	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62407

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
MMP20_HUMAN	33	FSYE.\|.EVLT	inferred from experiment	unknown	MEROPS	Li W	Zhu L et al.:Comparative properties of recom... (M10.019)	18336793,
MMP20_HUMAN	60	GGWL.\|.LHHQ	inferred from experiment	unknown	MEROPS	Li W	Zhu L et al.:Comparative properties of recom... (M10.019)	18336793,
MMP20_HUMAN	163	MFPM.\|.MQPL	inferred from experiment	unknown	MEROPS	Li W	Zhu L et al.:Comparative properties of recom... (M10.019)	18336793,
MMP20_HUMAN	172	MLPD.\|.DLTL	inferred from experiment	unknown	MEROPS	Li W	Zhu L et al.:Comparative properties of recom... (M10.019)	18336793,
MMP20_HUMAN	175	DLTL.\|.LEAW	inferred from experiment	unknown	MEROPS	Li W	Zhu L et al.:Comparative properties of recom... (M10.019)	18336793,
MMP20_HUMAN	176	LTLE.\|.EAWP	inferred from experiment	unknown	MEROPS	Li W	Zhu L et al.:Comparative properties of recom... (M10.019)	18336793,
MMP20_HUMAN	180	AWPS.\|.STDK	inferred from experiment	unknown	MEROPS	Li W	Zhu L et al.:Comparative properties of recom... (M10.019)	18336793,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)