Q99246: Voltage-dependent L-type calcium channel subunit alpha-1D
| Protein names | - Voltage-dependent L-type calcium channel subunit alpha-1D - Calcium channel, L type, alpha-1 polypeptide isoform 2 - Voltage-gated calcium channel subunit alpha Cav1.3 |
|---|---|
| Gene names | Cacna1d |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q99246 |
1
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MMMMMMMKKM QHQRQHQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA
70 80 90 100 110 120
RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI
130 140 150 160 170 180
SIVEWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI
190 200 210 220 230 240
IAYGLLLHPN AYVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR
250 260 270 280 290 300
AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT
310 320 330 340 350 360
CFFADSDIVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC
370 380 390 400 410 420
ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG
430 440 450 460 470 480
DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS
490 500 510 520 530 540
GEGETQGCCG TLWCWWKRRG AAKTGPSGCR RWGQAISKSK LSRRWRRWNR FNRRRCRAAV
550 560 570 580 590 600
KSVTFYWLVI VLVFLNTLTI SSEHYNQPDW LTQIQDIANK VLLALFTCEM LVKMYSLGLQ
610 620 630 640 650 660
AYFVSLFNRF DCFVVCGGIT ETILVELELM SPLGVSVFRC VRLLRIFKVT RHWTSLSNLV
670 680 690 700 710 720
ASLLNSMKSI ASLLLLLFLF IIIFSLLGMQ LFGGKFNFDE TQTKRSTFDN FPQALLTVFQ
730 740 750 760 770 780
ILTGEDWNAV MYDGIMAYGG PSSSGMIVCI YFIILFICGN YILLNVFLAI AVDNLADAES
790 800 810 820 830 840
LNTAQKEEAE EKERKKIARK ESLENKKNNK PEVNQIANSD NKVTIDDYQE DAEDKDPYPP
850 860 870 880 890 900
CDVPVGEEEE EEEEDEPEVP AGPRPRRISE LNMKEKIAPI PEGSAFFILS KTNPIRVGCH
910 920 930 940 950 960
KLINHHIFTN LILVFIMLSS AALAAEDPIR SHSFRNTILG YFDYAFTAIF TVEILLKMTT
970 980 990 1000 1010 1020
FGAFLHKGAF CRNYFNLLDM LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG
1030 1040 1050 1060 1070 1080
LKHVVQCVFV AIRTIGNIMI VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS NPEECRGLFI
1090 1100 1110 1120 1130 1140
LYKDGDVDSP VVRERIWQNS DFNFDNVLSA MMALFTVSTF EGWPALLYKA IDSNGENVGP
1150 1160 1170 1180 1190 1200
VYNYRVEISI FFIIYIIIVA FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL
1210 1220 1230 1240 1250 1260
KARPLRRYIP KNPYQYKFWY VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL
1270 1280 1290 1300 1310 1320
NMVFTGVFTV EMVLKVIAFK PKGYFSDAWN TFDSLIVIGS IIDVALSEAD PSESETIPLP
1330 1340 1350 1360 1370 1380
TATPGNSEES NRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIAML
1390 1400 1410 1420 1430 1440
FFIYAVIGMQ MFGKVAMRDN NQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLACLPGKL
1450 1460 1470 1480 1490 1500
CDPDSDYNPG EEYTCGSNFA IVYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH
1510 1520 1530 1540 1550 1560
HLDEFKRIWS EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVAMNMPLNS
1570 1580 1590 1600 1610 1620
DGTVMFNATL FALVRTALKI KTEGNLEQAN EELRAVIKKI WKKTSMKLLD QVVPPAGDDE
1630 1640 1650 1660 1670 1680
VTVGKFYATF LIQDYFRKFK KRKEQGLVGK YPAKNTTIAL QAGLRTLHDI GPEIRRAISC
1690 1700 1710 1720 1730 1740
DLQDDEPEDS KPEEEDVFKR NGALLGNHVN HVNSDRRDSL QQTNTTHRPL HVQRPSMPPA
1750 1760 1770 1780 1790 1800
SDTEKPLFPP AGNSGCHNHH NHNSIGKQAP TSTNANLNNA NMSKAAHGKP PSIGNLEHVS
1810 1820 1830 1840 1850 1860
ENGHYSCKHD RELQRRSSIK RTRYYETYIR SESGDEQFPT ICREDPEIHG YFRDPRCLGE
1870 1880 1890 1900 1910 1920
QEYFSSEECC EDDSSPTWSR QNYNYYNRYP GSSMDFERPR GYHHPQGFLE DDDSPTGYDS
1930 1940 1950 1960 1970 1980
RRSPRRRLLP PTPPSHRRSS FNFECLRRQS SQDDVLPSPA LPHRAALPLH LMQQQIMAVA
1990 2000 2010 2020 2030 2040
GLDSSKAQKY SPSHSTRSWA TPPATPPYRD WSPCYTPLIQ VDRSESMDQV NGSLPSLHRS
2050 2060 2070 2080 2090 2100
SWYTDEPDIS YRTFTPASLT VPSSFRNKNS DKQRSADSLV EAVLISEGLG RYARDPKFVS
2110 2120 2130 2140 2150 2160
ATKHEIADAC DLTIDEMESA ASTLLNGSVC PRANGDMGPI SHRQDYELQD FGPGYSDEEP
2170
DPGREEEDLA DEMICITTL
Isoforms
- Isoform 2 of Voltage-dependent L-type calcium channel subunit alpha-1D - Isoform 3 of Voltage-dependent L-type calcium channel subunit alpha-1DSequence View
10 20 30 40 50 60
MMMMMMMKKM QHQRQHQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA
70 80 90 100 110 120
RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI
130 140 150 160 170 180
SIVEWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI
190 200 210 220 230 240
IAYGLLLHPN AYVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR
250 260 270 280 290 300
AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT
310 320 330 340 350 360
CFFADSDIVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC
370 380 390 400 410 420
ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG
430 440 450 460 470 480
DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS
490 500 510 520 530 540
GEGETQGCCG TLWCWWKRRG AAKTGPSGCR RWGQAISKSK LSRRWRRWNR FNRRRCRAAV
550 560 570 580 590 600
KSVTFYWLVI VLVFLNTLTI SSEHYNQPDW LTQIQDIANK VLLALFTCEM LVKMYSLGLQ
610 620 630 640 650 660
AYFVSLFNRF DCFVVCGGIT ETILVELELM SPLGVSVFRC VRLLRIFKVT RHWTSLSNLV
670 680 690 700 710 720
ASLLNSMKSI ASLLLLLFLF IIIFSLLGMQ LFGGKFNFDE TQTKRSTFDN FPQALLTVFQ
730 740 750 760 770 780
ILTGEDWNAV MYDGIMAYGG PSSSGMIVCI YFIILFICGN YILLNVFLAI AVDNLADAES
790 800 810 820 830 840
LNTAQKEEAE EKERKKIARK ESLENKKNNK PEVNQIANSD NKVTIDDYQE DAEDKDPYPP
850 860 870 880 890 900
CDVPVGEEEE EEEEDEPEVP AGPRPRRISE LNMKEKIAPI PEGSAFFILS KTNPIRVGCH
910 920 930 940 950 960
KLINHHIFTN LILVFIMLSS AALAAEDPIR SHSFRNTILG YFDYAFTAIF TVEILLKMTT
970 980 990 1000 1010 1020
FGAFLHKGAF CRNYFNLLDM LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG
1030 1040 1050 1060 1070 1080
LKHVVQCVFV AIRTIGNIMI VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS NPEECRGLFI
1090 1100 1110 1120 1130 1140
LYKDGDVDSP VVRERIWQNS DFNFDNVLSA MMALFTVSTF EGWPALLYKA IDSNGENVGP
1150 1160 1170 1180 1190 1200
VYNYRVEISI FFIIYIIIVA FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL
1210 1220 1230 1240 1250 1260
KARPLRRYIP KNPYQYKFWY VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL
1270 1280 1290 1300 1310 1320
NMVFTGVFTV EMVLKVIAFK PKGYFSDAWN TFDSLIVIGS IIDVALSEAD PSESETIPLP
1330 1340 1350 1360 1370 1380
TATPGNSEES NRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIAML
1390 1400 1410 1420 1430 1440
FFIYAVIGMQ MFGKVAMRDN NQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLACLPGKL
1450 1460 1470 1480 1490 1500
CDPDSDYNPG EEYTCGSNFA IVYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH
1510 1520 1530 1540 1550 1560
HLDEFKRIWS EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVAMNMPLNS
1570 1580 1590 1600 1610 1620
DGTVMFNATL FALVRTALKI KTEGNLEQAN EELRAVIKKI WKKTSMKLLD QVVPPAGDDE
1630 1640 1650 1660 1670 1680
VTVGKFYATF LIQDYFRKFK KRKEQGLVGK YPAKNTTIAL QAGLRTLHDI GPEIRRAISC
1690 1700 1710 1720 1730 1740
DLQDDEPEDS KPEEEDVFKR NGALLGNHVN HVNSDRRDSL QQTNTTHRPL HVQRPSMPPA
1750 1760 1770 1780 1790 1800
SDTEKPLFPP AGNSGCHNHH NHNSIGKQAP TSTNANLNNA NMSKAAHGKP PSIGNLEHVS
1810 1820 1830 1840 1850 1860
ENGHYSCKHD RELQRRSSIK RTRYYETYIR SESGDEQFPT ICREDPEIHG YFRDPRCLGE
1870 1880 1890 1900 1910 1920
QEYFSSEECC EDDSSPTWSR QNYNYYNRYP GSSMDFERPR GYHHPQGFLE DDDSPTGYDS
1930 1940 1950 1960 1970 1980
RRSPRRRLLP PTPPSHRRSS FNFECLRRQS SQDDVLPSPA LPHRAALPLH LMQQQIMAVA
1990 2000 2010 2020 2030 2040
GLDSSKAQKY SPSHSTRSWA TPPATPPYRD WSPCYTPLIQ VDRSESMDQV NGSLPSLHRS
2050 2060 2070 2080 2090 2100
SWYTDEPDIS YRTFTPASLT VPSSFRNKNS DKQRSADSLV EAVLISEGLG RYARDPKFVS
2110 2120 2130 2140 2150 2160
ATKHEIADAC DLTIDEMESA ASTLLNGSVC PRANGDMGPI SHRQDYELQD FGPGYSDEEP
2170
DPGREEEDLA DEMICITTL
10 20 30 40 50 60
MMMMMMMKKM QHQRQHQEDH ANEANYARGT RLPISGEGPT SQPNSSKQTV LSWQAAIDAA
70 80 90 100 110 120
RQAKAAQTMS TSAPPPVGSL SQRKRQQYAK SKKQGNSSNS RPARALFCLS LNNPIRRACI
130 140 150 160 170 180
SIVEWKPFDI FILLAIFANC VALAIYIPFP EDDSNSTNHN LEKVEYAFLI IFTVETFLKI
190 200 210 220 230 240
IAYGLLLHPN AYVRNGWNLL DFVIVIVGLF SVILEQLTKE TEGGNHSSGK SGGFDVKALR
250 260 270 280 290 300
AFRVLRPLRL VSGVPSLQVV LNSIIKAMVP LLHIALLVLF VIIIYAIIGL ELFIGKMHKT
310 320 330 340 350 360
CFFADSDIVA EEDPAPCAFS GNGRQCTANG TECRSGWVGP NGGITNFDNF AFAMLTVFQC
370 380 390 400 410 420
ITMEGWTDVL YWVNDAIGWE WPWVYFVSLI ILGSFFVLNL VLGVLSGEFS KEREKAKARG
430 440 450 460 470 480
DFQKLREKQQ LEEDLKGYLD WITQAEDIDP ENEEEGGEEG KRNTSMPTSE TESVNTENVS
490 500 510 520 530 540
GEGETQGCCG TLWCWWKRRG AAKTGPSGCR RWGQAISKSK LSRRWRRWNR FNRRRCRAAV
550 560 570 580 590 600
KSVTFYWLVI VLVFLNTLTI SSEHYNQPDW LTQIQDIANK VLLALFTCEM LVKMYSLGLQ
610 620 630 640 650 660
AYFVSLFNRF DCFVVCGGIT ETILVELELM SPLGVSVFRC VRLLRIFKVT RHWTSLSNLV
670 680 690 700 710 720
ASLLNSMKSI ASLLLLLFLF IIIFSLLGMQ LFGGKFNFDE TQTKRSTFDN FPQALLTVFQ
730 740 750 760 770 780
ILTGEDWNAV MYDGIMAYGG PSSSGMIVCI YFIILFICGN YILLNVFLAI AVDNLADAES
790 800 810 820 830 840
LNTAQKEEAE EKERKKIARK ESLENKKNNK PEVNQIANSD NKVTIDDYQE DAEDKDPYPP
850 860 870 880 890 900
CDVPVGEEEE EEEEDEPEVP AGPRPRRISE LNMKEKIAPI PEGSAFFILS KTNPIRVGCH
910 920 930 940 950 960
KLINHHIFTN LILVFIMLSS AALAAEDPIR SHSFRNTILG YFDYAFTAIF TVEILLKMTT
970 980 990 1000 1010 1020
FGAFLHKGAF CRNYFNLLDM LVVGVSLVSF GIQSSAISVV KILRVLRVLR PLRAINRAKG
1030 1040 1050 1060 1070 1080
LKHVVQCVFV AIRTIGNIMI VTTLLQFMFA CIGVQLFKGK FYRCTDEAKS NPEECRGLFI
1090 1100 1110 1120 1130 1140
LYKDGDVDSP VVRERIWQNS DFNFDNVLSA MMALFTVSTF EGWPALLYKA IDSNGENVGP
1150 1160 1170 1180 1190 1200
VYNYRVEISI FFIIYIIIVA FFMMNIFVGF VIVTFQEQGE KEYKNCELDK NQRQCVEYAL
1210 1220 1230 1240 1250 1260
KARPLRRYIP KNPYQYKFWY VVNSSPFEYM MFVLIMLNTL CLAMQHYEQS KMFNDAMDIL
1270 1280 1290 1300 1310 1320
NMVFTGVFTV EMVLKVIAFK PKGYFSDAWN TFDSLIVIGS IIDVALSEAD PSESETIPLP
1330 1340 1350 1360 1370 1380
TATPGNSEES NRISITFFRL FRVMRLVKLL SRGEGIRTLL WTFIKSFQAL PYVALLIAML
1390 1400 1410 1420 1430 1440
FFIYAVIGMQ MFGKVAMRDN NQINRNNNFQ TFPQAVLLLF RCATGEAWQE IMLACLPGKL
1450 1460 1470 1480 1490 1500
CDPDSDYNPG EEYTCGSNFA IVYFISFYML CAFLIINLFV AVIMDNFDYL TRDWSILGPH
1510 1520 1530 1540 1550 1560
HLDEFKRIWS EYDPEAKGRI KHLDVVTLLR RIQPPLGFGK LCPHRVACKR LVAMNMPLNS
1570 1580 1590 1600 1610 1620
DGTVMFNATL FALVRTALKI KTEGNLEQAN EELRAVIKKI WKKTSMKLLD QVVPPAGDDE
1630 1640 1650 1660 1670 1680
VTVGKFYATF LIQDYFRKFK KRKEQGLVGK YPAKNTTIAL QAGLRTLHDI GPEIRRAISC
1690 1700 1710 1720 1730 1740
DLQDDEPEDS KPEEEDVFKR NGALLGNHVN HVNSDRRDSL QQTNTTHRPL HVQRPSMPPA
1750 1760 1770 1780 1790 1800
SDTEKPLFPP AGNSGCHNHH NHNSIGKQAP TSTNANLNNA NMSKAAHGKP PSIGNLEHVS
1810 1820 1830 1840 1850 1860
ENGHYSCKHD RELQRRSSIK RTRYYETYIR SESGDEQFPT ICREDPEIHG YFRDPRCLGE
1870 1880 1890 1900 1910 1920
QEYFSSEECC EDDSSPTWSR QNYNYYNRYP GSSMDFERPR GYHHPQGFLE DDDSPTGYDS
1930 1940 1950 1960 1970 1980
RRSPRRRLLP PTPPSHRRSS FNFECLRRQS SQDDVLPSPA LPHRAALPLH LMQQQIMAVA
1990 2000 2010 2020 2030 2040
GLDSSKAQKY SPSHSTRSWA TPPATPPYRD WSPCYTPLIQ VDRSESMDQV NGSLPSLHRS
2050 2060 2070 2080 2090 2100
SWYTDEPDIS YRTFTPASLT VPSSFRNKNS DKQRSADSLV EAVLISEGLG RYARDPKFVS
2110 2120 2130 2140 2150 2160
ATKHEIADAC DLTIDEMESA ASTLLNGSVC PRANGDMGPI SHRQDYELQD FGPGYSDEEP
2170
DPGREEEDLA DEMICITTL
Protein Neighborhood
Domains & Features
1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q99246-1-unknown | MMMMMM... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q99246-1-unknown | MMMMMM... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt69029 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...CITTL | 2179 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...CITTL | 2179 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64647 | |||
| ...CITTL | 2179 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt64648 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|