Q99439: Calponin-2

General Information

Protein names	- Calponin-2 - Calponin H2, smooth muscle - Neutral calponin
Gene names	CNN2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99439

8 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MSSTQFNKGP SYGLSAEVKN RLLSKYDPQK EAELRTWIEG LTGLSIGPDF QKGLKDGTIL
        70         80         90        100        110        120
CTLMNKLQPG SVPKINRSMQ NWHQLENLSN FIKAMVSYGM NPVDLFEAND LFESGNMTQV
       130        140        150        160        170        180
QVSLLALAGK AKTKGLQSGV DIGVKYSEKQ ERNFDDATMK AGQCVIGLQM GTNKCASQSG
       190        200        210        220        230        240
MTAYGTRRHL YDPKNHILPP MDHSTISLQM GTNKCASQVG MTAPGTRRHI YDTKLGTDKC
       250        260        270        280        290        300
DNSSMSLQMG YTQGANQSGQ VFGLGRQIYD PKYCPQGTVA DGAPSGTGDC PDPGEVPEYP

PYYQEEAGY

Isoforms

- Isoform 2 of Calponin-2

Sequence View

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Protease Assignment Confidence:

Evidence Names:

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Protein Neighborhood

Domains & Features

8 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q99439-1-unknown	MSSTQF...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt71143
Q99439-2-unknown	MSSTQF...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99439-2-Acetylation	SSTQFN...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q99439-2-Acetylation	SSTQFN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q99439-2-Acetylation	SSTQFN...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q99439-2-Acetylation	SSTQFN...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt111721
Q99439-142-unknown	IGVKYS...	142		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2311
Q99439-250-unknown	GYTQGA...	250		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167213
Q99439-250-	GYTQGA...	250			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99439-254-unknown	GANQSG...	254		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt167215
Q99439-254-	GANQSG...	254			Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q99439-254-	GANQSG...	254			Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QSGVDI	141	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2311
...EEAGY	309	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...EEAGY	309	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt66761

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	141	GVDI.\|.IGVK	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> CNN2_HUMAN @141

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)