Q99504: Eyes absent homolog 3

General Information

Protein names	- Eyes absent homolog 3 - 3.1.3.48 {ECO:0000269\|PubMed:19234442, ECO:0000269\|PubMed:19351884}
Gene names	EYA3
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99504

4 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Eyes absent homolog 3 - Isoform 3 of Eyes absent homolog 3 - Isoform 4 of Eyes absent homolog 3 - Isoform 5 of Eyes absent homolog 3

Sequence View

        10         20         30         40         50         60
MEEEQDLPEQ PVKKAKMQES GEQTISQVSN PDVSDQKPET SSLASNLPMS EEIMTCTDYI
        70         80         90        100        110        120
PRSSNDYTSQ MYSAKPYAHI LSVPVSETAY PGQTQYQTLQ QTQPYAVYPQ ATQTYGLPPF
       130        140        150        160        170        180
GALWPGMKPE SGLIQTPSPS QHSVLTCTTG LTTSQPSPAH YSYPIQASST NASLISTSST
       190        200        210        220        230        240
IANIPAAAVA SISNQDYPTY TILGQNQYQA CYPSSSFGVT GQTNSDAEST TLAATTYQSE
       250        260        270        280        290        300
KPSVMAPAPA AQRLSSGDPS TSPSLSQTTP SKDTDDQSRK NMTSKNRGKR KADATSSQDS
       310        320        330        340        350        360
ELERVFLWDL DETIIIFHSL LTGSYAQKYG KDPTVVIGSG LTMEEMIFEV ADTHLFFNDL
       370        380        390        400        410        420
EECDQVHVED VASDDNGQDL SNYSFSTDGF SGSGGSGSHG SSVGVQGGVD WMRKLAFRYR
       430        440        450        460        470        480
KVREIYDKHK SNVGGLLSPQ RKEALQRLRA EIEVLTDSWL GTALKSLLLI QSRKNCVNVL
       490        500        510        520        530        540
ITTTQLVPAL AKVLLYGLGE IFPIENIYSA TKIGKESCFE RIVSRFGKKV TYVVIGDGRD
       550        560        570
EEIAAKQHNM PFWRITNHGD LVSLHQALEL DFL         10         20         30         40         50         60
MEEEQDLPEQ PVKKAKMQES GEQTISQVSN PDVSDQKPET SSLASNLPMS EEIMTCTDYI
        70         80         90        100        110        120
PRSSNDYTSQ MYSAKPYAHI LSVPVSETAY PGQTQYQTLQ QTQPYAVYPQ ATQTYGLPPF
       130        140        150        160        170        180
GALWPGMKPE SGLIQTPSPS QHSVLTCTTG LTTSQPSPAH YSYPIQASST NASLISTSST
       190        200        210        220        230        240
IANIPAAAVA SISNQDYPTY TILGQNQYQA CYPSSSFGVT GQTNSDAEST TLAATTYQSE
       250        260        270        280        290        300
KPSVMAPAPA AQRLSSGDPS TSPSLSQTTP SKDTDDQSRK NMTSKNRGKR KADATSSQDS
       310        320        330        340        350        360
ELERVFLWDL DETIIIFHSL LTGSYAQKYG KDPTVVIGSG LTMEEMIFEV ADTHLFFNDL
       370        380        390        400        410        420
EECDQVHVED VASDDNGQDL SNYSFSTDGF SGSGGSGSHG SSVGVQGGVD WMRKLAFRYR
       430        440        450        460        470        480
KVREIYDKHK SNVGGLLSPQ RKEALQRLRA EIEVLTDSWL GTALKSLLLI QSRKNCVNVL
       490        500        510        520        530        540
ITTTQLVPAL AKVLLYGLGE IFPIENIYSA TKIGKESCFE RIVSRFGKKV TYVVIGDGRD
       550        560        570
EEIAAKQHNM PFWRITNHGD LVSLHQALEL DFL         10         20         30         40         50         60
MEEEQDLPEQ PVKKAKMQES GEQTISQVSN PDVSDQKPET SSLASNLPMS EEIMTCTDYI
        70         80         90        100        110        120
PRSSNDYTSQ MYSAKPYAHI LSVPVSETAY PGQTQYQTLQ QTQPYAVYPQ ATQTYGLPPF
       130        140        150        160        170        180
GALWPGMKPE SGLIQTPSPS QHSVLTCTTG LTTSQPSPAH YSYPIQASST NASLISTSST
       190        200        210        220        230        240
IANIPAAAVA SISNQDYPTY TILGQNQYQA CYPSSSFGVT GQTNSDAEST TLAATTYQSE
       250        260        270        280        290        300
KPSVMAPAPA AQRLSSGDPS TSPSLSQTTP SKDTDDQSRK NMTSKNRGKR KADATSSQDS
       310        320        330        340        350        360
ELERVFLWDL DETIIIFHSL LTGSYAQKYG KDPTVVIGSG LTMEEMIFEV ADTHLFFNDL
       370        380        390        400        410        420
EECDQVHVED VASDDNGQDL SNYSFSTDGF SGSGGSGSHG SSVGVQGGVD WMRKLAFRYR
       430        440        450        460        470        480
KVREIYDKHK SNVGGLLSPQ RKEALQRLRA EIEVLTDSWL GTALKSLLLI QSRKNCVNVL
       490        500        510        520        530        540
ITTTQLVPAL AKVLLYGLGE IFPIENIYSA TKIGKESCFE RIVSRFGKKV TYVVIGDGRD
       550        560        570
EEIAAKQHNM PFWRITNHGD LVSLHQALEL DFL         10         20         30         40         50         60
MEEEQDLPEQ PVKKAKMQES GEQTISQVSN PDVSDQKPET SSLASNLPMS EEIMTCTDYI
        70         80         90        100        110        120
PRSSNDYTSQ MYSAKPYAHI LSVPVSETAY PGQTQYQTLQ QTQPYAVYPQ ATQTYGLPPF
       130        140        150        160        170        180
GALWPGMKPE SGLIQTPSPS QHSVLTCTTG LTTSQPSPAH YSYPIQASST NASLISTSST
       190        200        210        220        230        240
IANIPAAAVA SISNQDYPTY TILGQNQYQA CYPSSSFGVT GQTNSDAEST TLAATTYQSE
       250        260        270        280        290        300
KPSVMAPAPA AQRLSSGDPS TSPSLSQTTP SKDTDDQSRK NMTSKNRGKR KADATSSQDS
       310        320        330        340        350        360
ELERVFLWDL DETIIIFHSL LTGSYAQKYG KDPTVVIGSG LTMEEMIFEV ADTHLFFNDL
       370        380        390        400        410        420
EECDQVHVED VASDDNGQDL SNYSFSTDGF SGSGGSGSHG SSVGVQGGVD WMRKLAFRYR
       430        440        450        460        470        480
KVREIYDKHK SNVGGLLSPQ RKEALQRLRA EIEVLTDSWL GTALKSLLLI QSRKNCVNVL
       490        500        510        520        530        540
ITTTQLVPAL AKVLLYGLGE IFPIENIYSA TKIGKESCFE RIVSRFGKKV TYVVIGDGRD
       550        560        570
EEIAAKQHNM PFWRITNHGD LVSLHQALEL DFL

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q99504-1-Acetylation	MEEEQD...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99504-1-Acetylation	MEEEQD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100672
Q99504-1-Acetylation	MEEEQD...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt100673
Q99504-1-unknown	MEEEQD...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74344
Q99504-1-unknown	MEEEQD...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74346
Q99504-54-unknown	MTCTDY...	54		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74345
Q99504-54-unknown	MTCTDY...	54		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000442280
Q99504-54-unknown	MTCTDY...	54		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101864
Q99504-54-unknown	MTCTDY...	54		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101865
Q99504-127-unknown	MKPESG...	127		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt74343
Q99504-127-unknown	MKPESG...	127		inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405587
Q99504-127-unknown	MKPESG...	127		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt101736

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ELDFL	573	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ELDFL	573	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69961
...ELDFL	573	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69963
...ELDFL	573	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69964

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)