Q99755: Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

General Information

Protein names	- Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha - PIP5K1-alpha - PtdIns(4)P-5-kinase 1 alpha - 2.7.1.68 - 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha - Phosphatidylinositol 4-phosphate 5-kinase type I alpha - PIP5KIalpha
Gene names	PIP5K1A
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99755

2 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha - Isoform 3 of Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha - Isoform 4 of Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Sequence View

        10         20         30         40         50         60
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI SLVPYASGMP
        70         80         90        100        110        120
IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL STKPERDVLM QDFYVVESIF
       130        140        150        160        170        180
FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF RELFGIRPDD YLYSLCSEPL IELCSSGASG
       190        200        210        220        230        240
SLFYVSSDDE FIIKTVQHKE AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR
       250        260        270        280        290        300
IVVMNNLLPR SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM
       310        320        330        340        350        360
YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT RRPAPQKALY
       370        380        390        400        410        420
STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI GIIDILQSYR FVKKLEHSWK
       430        440        450        460        470        480
ALVHDGDTVS VHRPGFYAER FQRFMCNTVF KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC
       490        500        510        520        530        540
ITYQPSVSGE HKAQVTTKAE VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET
       550        560
LQMLTTSTTL EKLEVAESEF TH         10         20         30         40         50         60
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI SLVPYASGMP
        70         80         90        100        110        120
IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL STKPERDVLM QDFYVVESIF
       130        140        150        160        170        180
FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF RELFGIRPDD YLYSLCSEPL IELCSSGASG
       190        200        210        220        230        240
SLFYVSSDDE FIIKTVQHKE AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR
       250        260        270        280        290        300
IVVMNNLLPR SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM
       310        320        330        340        350        360
YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT RRPAPQKALY
       370        380        390        400        410        420
STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI GIIDILQSYR FVKKLEHSWK
       430        440        450        460        470        480
ALVHDGDTVS VHRPGFYAER FQRFMCNTVF KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC
       490        500        510        520        530        540
ITYQPSVSGE HKAQVTTKAE VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET
       550        560
LQMLTTSTTL EKLEVAESEF TH         10         20         30         40         50         60
MASASSGPSS SVGFSSFDPA VPSCTLSSAA SGIKRPMASE VLEARQDSYI SLVPYASGMP
        70         80         90        100        110        120
IKKIGHRSVD SSGETTYKKT TSSALKGAIQ LGITHTVGSL STKPERDVLM QDFYVVESIF
       130        140        150        160        170        180
FPSEGSNLTP AHHYNDFRFK TYAPVAFRYF RELFGIRPDD YLYSLCSEPL IELCSSGASG
       190        200        210        220        230        240
SLFYVSSDDE FIIKTVQHKE AEFLQKLLPG YYMNLNQNPR TLLPKFYGLY CVQAGGKNIR
       250        260        270        280        290        300
IVVMNNLLPR SVKMHIKYDL KGSTYKRRAS QKEREKPLPT FKDLDFLQDI PDGLFLDADM
       310        320        330        340        350        360
YNALCKTLQR DCLVLQSFKI MDYSLLMSIH NIDHAQREPL SSETQYSVDT RRPAPQKALY
       370        380        390        400        410        420
STAMESIQGE ARRGGTMETD DHMGGIPARN SKGERLLLYI GIIDILQSYR FVKKLEHSWK
       430        440        450        460        470        480
ALVHDGDTVS VHRPGFYAER FQRFMCNTVF KKIPLKPSPS KKFRSGSSFS RRAGSSGNSC
       490        500        510        520        530        540
ITYQPSVSGE HKAQVTTKAE VEPGVHLGRP DVLPQTPPLE EISEGSPIPD PSFSPLVGET
       550        560
LQMLTTSTTL EKLEVAESEF TH

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99755-1-unknown	MASASS...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99755-1-unknown	MASASS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85133
Q99755-1-unknown	MASASS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85134
Q99755-1-unknown	MASASS...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt85135
Q99755-293-unknown	GLFLDA...	293	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2315
Q99755-293-unknown	GLFLDA...	293	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149331
Q99755-293-unknown	GLFLDA...	293	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149332
Q99755-293-unknown	GLFLDA...	293	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt149358

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QDIPDG	292	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC2315
...QDIPDG	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132716
...QDIPDG	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132717
...QDIPDG	292	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt132742
...SEFTH	562	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...SEFTH	562	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80751
...SEFTH	562	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80753
...SEFTH	562	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt80752

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	292	IPDG.\|.GLFL	inferred from experiment	unknown	MEROPS	Yin HL	Mejillano M et al.:Regulation of apoptosis by phos... (C14.003)	11042212,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)