TopFIND 4.0

Q99759: Mitogen-activated protein kinase kinase kinase 3

General Information

Protein names
- Mitogen-activated protein kinase kinase kinase 3
- 2.7.11.25
- MAPK/ERK kinase kinase 3
- MEK kinase 3
- MEKK 3
Gene names MAP3K3
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q99759

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQSDVRIKFE HNGERRIIAF 
        70         80         90        100        110        120 
SRPVKYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL DKAIDILDRS SSMKSLRILL 
       130        140        150        160        170        180 
LSQDRNHNSS SPHSGVSRQV RIKASQSAGD INTIYQPPEP RSRHLSVSSQ NPGRSSPPPG 
       190        200        210        220        230        240 
YVPERQQHIA RQGSYTSINS EGEFIPETSE QCMLDPLSSA ENSLSGSCQS LDRSADSPSF 
       250        260        270        280        290        300 
RKSRMSRAQS FPDNRQEYSD RETQLYDKGV KGGTYPRRYH VSVHHKDYSD GRRTFPRIRR 
       310        320        330        340        350        360 
HQGNLFTLVP SSRSLSTNGE NMGLAVQYLD PRGRLRSADS ENALSVQERN VPTKSPSAPI 
       370        380        390        400        410        420 
NWRRGKLLGQ GAFGRVYLCY DVDTGRELAS KQVQFDPDSP ETSKEVSALE CEIQLLKNLQ 
       430        440        450        460        470        480 
HERIVQYYGC LRDRAEKTLT IFMEYMPGGS VKDQLKAYGA LTESVTRKYT RQILEGMSYL 
       490        500        510        520        530        540 
HSNMIVHRDI KGANILRDSA GNVKLGDFGA SKRLQTICMS GTGMRSVTGT PYWMSPEVIS 
       550        560        570        580        590        600 
GEGYGRKADV WSLGCTVVEM LTEKPPWAEY EAMAAIFKIA TQPTNPQLPS HISEHGRDFL 
       610        620    
RRIFVEARQR PSAEELLTHH FAQLMY

Isoforms

- Isoform 2 of Mitogen-activated protein kinase kinase kinase 3

Sequence View

        10         20         30         40         50         60 
MDEQEALNSI MNDLVALQMN RRHRMPGYET MKNKDTGHSN RQSDVRIKFE HNGERRIIAF 
        70         80         90        100        110        120 
SRPVKYEDVE HKVTTVFGQP LDLHYMNNEL SILLKNQDDL DKAIDILDRS SSMKSLRILL 
       130        140        150        160        170        180 
LSQDRNHNSS SPHSGVSRQV RIKASQSAGD INTIYQPPEP RSRHLSVSSQ NPGRSSPPPG 
       190        200        210        220        230        240 
YVPERQQHIA RQGSYTSINS EGEFIPETSE QCMLDPLSSA ENSLSGSCQS LDRSADSPSF 
       250        260        270        280        290        300 
RKSRMSRAQS FPDNRQEYSD RETQLYDKGV KGGTYPRRYH VSVHHKDYSD GRRTFPRIRR 
       310        320        330        340        350        360 
HQGNLFTLVP SSRSLSTNGE NMGLAVQYLD PRGRLRSADS ENALSVQERN VPTKSPSAPI 
       370        380        390        400        410        420 
NWRRGKLLGQ GAFGRVYLCY DVDTGRELAS KQVQFDPDSP ETSKEVSALE CEIQLLKNLQ 
       430        440        450        460        470        480 
HERIVQYYGC LRDRAEKTLT IFMEYMPGGS VKDQLKAYGA LTESVTRKYT RQILEGMSYL 
       490        500        510        520        530        540 
HSNMIVHRDI KGANILRDSA GNVKLGDFGA SKRLQTICMS GTGMRSVTGT PYWMSPEVIS 
       550        560        570        580        590        600 
GEGYGRKADV WSLGCTVVEM LTEKPPWAEY EAMAAIFKIA TQPTNPQLPS HISEHGRDFL 
       610        620    
RRIFVEARQR PSAEELLTHH FAQLMY



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Directness:


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Evidence Codes:


Methodology:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q99759-1-unknown MDEQEA... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q99759-1-unknown MDEQEA... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt80168

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...AQLMY 626 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...AQLMY 626 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt75786

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)