TopFIND 4.0

Q99952: Tyrosine-protein phosphatase non-receptor type 18

General Information

Protein names
- Tyrosine-protein phosphatase non-receptor type 18
- 3.1.3.48
- Brain-derived phosphatase
Gene names PTPN18
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q99952

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA GSRPENVRKN 
        70         80         90        100        110        120 
RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA YIATQGPLPH TLLDFWRLVW 
       130        140        150        160        170        180 
EFGVKVILMA CREIENGRKR CERYWAQEQE PLQTGLFCIT LIKEKWLNED IMLRTLKVTF 
       190        200        210        220        230        240 
QKESRSVYQL QYMSWPDRGV PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC 
       250        260        270        280        290        300 
TVDYVRQLLL TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS 
       310        320        330        340        350        360 
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM ADTYAVVQKR 
       370        380        390        400        410        420 
GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG AHAEDARGTL PGRVPADQSP 
       430        440        450        460    
AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP RDPPAEWTRV 

Isoforms

- Isoform 2 of Tyrosine-protein phosphatase non-receptor type 18

Sequence View

        10         20         30         40         50         60 
MSRSLDSARS FLERLEARGG REGAVLAGEF SDIQACSAAW KADGVCSTVA GSRPENVRKN 
        70         80         90        100        110        120 
RYKDVLPYDQ TRVILSLLQE EGHSDYINGN FIRGVDGSLA YIATQGPLPH TLLDFWRLVW 
       130        140        150        160        170        180 
EFGVKVILMA CREIENGRKR CERYWAQEQE PLQTGLFCIT LIKEKWLNED IMLRTLKVTF 
       190        200        210        220        230        240 
QKESRSVYQL QYMSWPDRGV PSSPDHMLAM VEEARRLQGS GPEPLCVHCS AGCGRTGVLC 
       250        260        270        280        290        300 
TVDYVRQLLL TQMIPPDFSL FDVVLKMRKQ RPAAVQTEEQ YRFLYHTVAQ MFCSTLQNAS 
       310        320        330        340        350        360 
PHYQNIKENC APLYDDALFL RTPQALLAIP RPPGGVLRSI SVPGSPGHAM ADTYAVVQKR 
       370        380        390        400        410        420 
GAPAGAGSGT QTGTGTGTGA RSAEEAPLYS KVTPRAQRPG AHAEDARGTL PGRVPADQSP 
       430        440        450        460    
AGSGAYEDVA GGAQTGGLGF NLRIGRPKGP RDPPAEWTRV 



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q99952-1-unknown MSRSLD... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q99952-1-unknown MSRSLD... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt86496

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...EWTRV 460 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...EWTRV 460 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt82114

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)