Q99K90: TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

General Information

Protein names	- TGF-beta-activated kinase 1 and MAP3K7-binding protein 2 - Mitogen-activated protein kinase kinase kinase 7-interacting protein 2 - TAK1-binding protein 2 - TAB-2 - TGF-beta-activated kinase 1-binding protein 2
Gene names	Tab2
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q99K90

3 N-termini

4 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAQGSHQIDF QVLHDLRQKF PEVPEVVVSR CMLQNNNNLD ACCAVLSQES TRYLYGEGDL
        70         80         90        100        110        120
NFSDESGISG LRNHMTSLNL DLQSQNVYHH GREGSRVNGS RTLTHSVSDG QLHGGQSNNE
       130        140        150        160        170        180
LFQQEPQTAP AQVPQGFNVF GMPSTSGASN STPHLGFHLG SKGTSNLSQQ TPRFNPIMVT
       190        200        210        220        230        240
LAPNIQTGRS TPTSLHIHGV PPPVLNSPQG NSIYIRPYIT TPSGTARQTQ QHSGWVSQFN
       250        260        270        280        290        300
PMNPQQAYQP SQPGPWTTYP ASNPLPHTST QQPNQQGHQT SHVYMPISSP TTPQPPTIHS
       310        320        330        340        350        360
SGSSQSSAHS QYNIQNISTG PRKNQIEIKL EPPQRNSSSK LRSSGPRTAS TSSLVNSQTL
       370        380        390        400        410        420
NRNQPTVYIA ASPPNTDEMI SRSQPKVYIS ANATAGDEQG MRNQPTLFIS TNSGPSAASR
       430        440        450        460        470        480
NMSGQVSMGP AFIHHHPPKS RVLGGNSATS PRVVVTQPNT KYTFKITVSP NKPPAVSPGV
       490        500        510        520        530        540
VSPTFELTNL LNHPDHYVET ENIQHLTDPA LAHVDRISEA RKLSMGSDDA AYTQALLVHQ
       550        560        570        580        590        600
KARMERLQRE LEMQKKKLDK LKSEVNEMEN NLTRRRLKRS NSISQIPSLE EMQQLRSCNR
       610        620        630        640        650        660
QLQIDIDCLT KEIDLFQARG PHFNPSAIHN FYDNIGFVGP VPPKPKDQRS TIKAPKTQDA
       670        680        690
EDEEGAQWNC TACTFLNHPA LIRCEQCEMP RHF

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q99K90-1-unknown	MAQGSH...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q99K90-75-unknown	MTSLNL...	75	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122559
Q99K90-409-unknown	ISTNSG...	409	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30958

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...QPTLFI	408	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC30958
...VTQPNT	459	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000122559
...RELEMQ	553	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSMUSP00000119515
...MPRHF	693	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	408	TLFI.\|.ISTN	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> TAB2_MOUSE @408

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)