TopFIND 4.0

Q99MP8: BRCA1-associated protein

General Information

Protein names
- BRCA1-associated protein
- 2.3.2.27 {ECO:0000250|UniProtKB:Q7Z569}
- BRAP2
- Impedes mitogenic signal propagation
- IMP
- RING-type E3 ubiquitin transferase BRAP2 {ECO:0000305}
Gene names Brap
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q99MP8

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MSVSLVVIRL ELAGHSPVPT DFGFSAAAGE MSDEEIKKKT LASAVACLEG KSAGEKAAII 
        70         80         90        100        110        120 
HQHLGRREMT DVIIETMKAR ADEVRDTVEE KKPSAAPVSA QRSREQSESV NTAPESPSKQ 
       130        140        150        160        170        180 
LPDQISFFSG NPSVEIVHGI MHLYKTNKMT SLKEDVRRSA MLCVLTVPAT MTSHDLMKFV 
       190        200        210        220        230        240 
APFNDVIEQM KIIRDSTPNQ YMVLIKFSAQ ADADSFYMAC NGRQFNSIED DVCQLVYVER 
       250        260        270        280        290        300 
AEVLKSEDGA SLPVMDLTEL PKCTVCLERM DESVNGILTT LCNHSFHSQC LQRWDDTTCP 
       310        320        330        340        350        360 
VCRYCQTPEP VEENKCFECG VQENLWICLI CGHIGCGRYV SRHAYKHFEE TQHTYAMQLT 
       370        380        390        400        410        420 
NHRVWDYAGD NYVHRLVASK TDGKIVQYEC EGDTCQEEKI DALQLEYSYL LTSQLESQRI 
       430        440        450        460        470        480 
YWENKIVRIE KDTAEEINNM KTKFKETIEK CDSLELRLSD LLKEKQSVER KCTQLNTRVA 
       490        500        510        520        530        540 
KLSTELQEEQ ELNKCLRANQ LVLQNQLKEE EKLLKETCAQ KDLQITEIQE QLRDVMFYLE 
       550        560        570        580        590    
TQQQISHLPA ETRQEIQEGQ INIAMASAPN PPSSGAGGKL QSRKGRSKRG K

Isoforms

- Isoform 2 of BRCA1-associated protein - Isoform 3 of BRCA1-associated protein

Sequence View

        10         20         30         40         50         60 
MSVSLVVIRL ELAGHSPVPT DFGFSAAAGE MSDEEIKKKT LASAVACLEG KSAGEKAAII 
        70         80         90        100        110        120 
HQHLGRREMT DVIIETMKAR ADEVRDTVEE KKPSAAPVSA QRSREQSESV NTAPESPSKQ 
       130        140        150        160        170        180 
LPDQISFFSG NPSVEIVHGI MHLYKTNKMT SLKEDVRRSA MLCVLTVPAT MTSHDLMKFV 
       190        200        210        220        230        240 
APFNDVIEQM KIIRDSTPNQ YMVLIKFSAQ ADADSFYMAC NGRQFNSIED DVCQLVYVER 
       250        260        270        280        290        300 
AEVLKSEDGA SLPVMDLTEL PKCTVCLERM DESVNGILTT LCNHSFHSQC LQRWDDTTCP 
       310        320        330        340        350        360 
VCRYCQTPEP VEENKCFECG VQENLWICLI CGHIGCGRYV SRHAYKHFEE TQHTYAMQLT 
       370        380        390        400        410        420 
NHRVWDYAGD NYVHRLVASK TDGKIVQYEC EGDTCQEEKI DALQLEYSYL LTSQLESQRI 
       430        440        450        460        470        480 
YWENKIVRIE KDTAEEINNM KTKFKETIEK CDSLELRLSD LLKEKQSVER KCTQLNTRVA 
       490        500        510        520        530        540 
KLSTELQEEQ ELNKCLRANQ LVLQNQLKEE EKLLKETCAQ KDLQITEIQE QLRDVMFYLE 
       550        560        570        580        590    
TQQQISHLPA ETRQEIQEGQ INIAMASAPN PPSSGAGGKL QSRKGRSKRG K         10         20         30         40         50         60 
MSVSLVVIRL ELAGHSPVPT DFGFSAAAGE MSDEEIKKKT LASAVACLEG KSAGEKAAII 
        70         80         90        100        110        120 
HQHLGRREMT DVIIETMKAR ADEVRDTVEE KKPSAAPVSA QRSREQSESV NTAPESPSKQ 
       130        140        150        160        170        180 
LPDQISFFSG NPSVEIVHGI MHLYKTNKMT SLKEDVRRSA MLCVLTVPAT MTSHDLMKFV 
       190        200        210        220        230        240 
APFNDVIEQM KIIRDSTPNQ YMVLIKFSAQ ADADSFYMAC NGRQFNSIED DVCQLVYVER 
       250        260        270        280        290        300 
AEVLKSEDGA SLPVMDLTEL PKCTVCLERM DESVNGILTT LCNHSFHSQC LQRWDDTTCP 
       310        320        330        340        350        360 
VCRYCQTPEP VEENKCFECG VQENLWICLI CGHIGCGRYV SRHAYKHFEE TQHTYAMQLT 
       370        380        390        400        410        420 
NHRVWDYAGD NYVHRLVASK TDGKIVQYEC EGDTCQEEKI DALQLEYSYL LTSQLESQRI 
       430        440        450        460        470        480 
YWENKIVRIE KDTAEEINNM KTKFKETIEK CDSLELRLSD LLKEKQSVER KCTQLNTRVA 
       490        500        510        520        530        540 
KLSTELQEEQ ELNKCLRANQ LVLQNQLKEE EKLLKETCAQ KDLQITEIQE QLRDVMFYLE 
       550        560        570        580        590    
TQQQISHLPA ETRQEIQEGQ INIAMASAPN PPSSGAGGKL QSRKGRSKRG K



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(REFRESH)

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Evidence Codes:


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Biological System:


Protease Assignment Confidence:


Evidence Names:


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Lab:



Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q99MP8-1-unknown MSVSLV... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q99MP8-31-unknown MSDEEI... 31 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt68587
    Q99MP8-218-unknown MACNGR... 218 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt68588
    Q99MP8-218-unknown MACNGR... 218 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt108945

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)