TopFIND 4.0

Q9BQB4: Sclerostin {ECO:0000250|UniProtKB:Q99P68}

General Information

Protein names
- Sclerostin {ECO:0000250|UniProtKB:Q99P68}
Gene names SOST
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9BQB4

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MQLPLALCLV CLLVHTAFRV VEGQGWQAFK NDATEIIPEL GEYPEPPPEL ENNKTMNRAE 
        70         80         90        100        110        120 
NGGRPPHHPF ETKDVSEYSC RELHFTRYVT DGPCRSAKPV TELVCSGQCG PARLLPNAIG 
       130        140        150        160        170        180 
RGKWWRPSGP DFRCIPDRYR AQRVQLLCPG GEAPRARKVR LVASCKCKRL TRFHNQSELK 
       190        200        210    
DFGTEAARPQ KGRKPRPRAR SAKANQAELE NAY

Isoforms

- Isoform 2 of Sclerostin

Sequence View

        10         20         30         40         50         60 
MQLPLALCLV CLLVHTAFRV VEGQGWQAFK NDATEIIPEL GEYPEPPPEL ENNKTMNRAE 
        70         80         90        100        110        120 
NGGRPPHHPF ETKDVSEYSC RELHFTRYVT DGPCRSAKPV TELVCSGQCG PARLLPNAIG 
       130        140        150        160        170        180 
RGKWWRPSGP DFRCIPDRYR AQRVQLLCPG GEAPRARKVR LVASCKCKRL TRFHNQSELK 
       190        200        210    
DFGTEAARPQ KGRKPRPRAR SAKANQAELE NAY



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Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9BQB4-1-unknown MQLPLA... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt90276
    Q9BQB4-24-unknown QGWQAF... 24 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9BQB4-24-unknown QGWQAF... 24 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt113497

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LENAY 213 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...LENAY 213 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt85894

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)