Q9BQC3: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 {ECO:0000305}

General Information

Protein names	- 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 {ECO:0000305} - 2.5.1.108 {ECO:0000250\|UniProtKB:Q9CR25} - Diphthamide biosynthesis protein 2 - Diphtheria toxin resistance protein 2 {ECO:0000305} - S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 2 {ECO:0000305}
Gene names	DPH2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BQC3

3 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Diphthamide biosynthesis protein 2 - Isoform 2 of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 - Isoform 3 of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

Sequence View

        10         20         30         40         50         60
MESMFSSPAE AALQRETGVP GLLTPLPDLD GVYELERVAG FVRDLGCERV ALQFPDQLLG
        70         80         90        100        110        120
DAVAVAARLE ETTGSKMFIL GDTAYGSCCV DVLGAEQAGA QALIHFGPAC LSPPARPLPV
       130        140        150        160        170        180
AFVLRQRSVA LELCVKAFEA QNPDPKAPVV LLSEPACAHA LEALATLLRP RYLDLLVSSP
       190        200        210        220        230        240
AFPQPVGSLS PEPMPLERFG RRFPLAPGRR LEEYGAFYVG GSKASPDPDL DPDLSRLLLG
       250        260        270        280        290        300
WAPGQPFSSC CPDTGKTQDE GARAGRLRAR RRYLVERARD ARVVGLLAGT LGVAQHREAL
       310        320        330        340        350        360
AHLRNLTQAA GKRSYVLALG RPTPAKLANF PEVDVFVLLA CPLGALAPQL SGSFFQPILA
       370        380        390        400        410        420
PCELEAACNP AWPPPGLAPH LTHYADLLPG SPFHVALPPP ESELWETPDV SLITGDLRPP
       430        440        450        460        470        480
PAWKSSNDHG SLALTPRPQL ELAESSPAAS FLSSRSWQGL EPRLGQTPVT EAVSGRRGIA

IAYEDEGSG         10         20         30         40         50         60
MESMFSSPAE AALQRETGVP GLLTPLPDLD GVYELERVAG FVRDLGCERV ALQFPDQLLG
        70         80         90        100        110        120
DAVAVAARLE ETTGSKMFIL GDTAYGSCCV DVLGAEQAGA QALIHFGPAC LSPPARPLPV
       130        140        150        160        170        180
AFVLRQRSVA LELCVKAFEA QNPDPKAPVV LLSEPACAHA LEALATLLRP RYLDLLVSSP
       190        200        210        220        230        240
AFPQPVGSLS PEPMPLERFG RRFPLAPGRR LEEYGAFYVG GSKASPDPDL DPDLSRLLLG
       250        260        270        280        290        300
WAPGQPFSSC CPDTGKTQDE GARAGRLRAR RRYLVERARD ARVVGLLAGT LGVAQHREAL
       310        320        330        340        350        360
AHLRNLTQAA GKRSYVLALG RPTPAKLANF PEVDVFVLLA CPLGALAPQL SGSFFQPILA
       370        380        390        400        410        420
PCELEAACNP AWPPPGLAPH LTHYADLLPG SPFHVALPPP ESELWETPDV SLITGDLRPP
       430        440        450        460        470        480
PAWKSSNDHG SLALTPRPQL ELAESSPAAS FLSSRSWQGL EPRLGQTPVT EAVSGRRGIA

IAYEDEGSG         10         20         30         40         50         60
MESMFSSPAE AALQRETGVP GLLTPLPDLD GVYELERVAG FVRDLGCERV ALQFPDQLLG
        70         80         90        100        110        120
DAVAVAARLE ETTGSKMFIL GDTAYGSCCV DVLGAEQAGA QALIHFGPAC LSPPARPLPV
       130        140        150        160        170        180
AFVLRQRSVA LELCVKAFEA QNPDPKAPVV LLSEPACAHA LEALATLLRP RYLDLLVSSP
       190        200        210        220        230        240
AFPQPVGSLS PEPMPLERFG RRFPLAPGRR LEEYGAFYVG GSKASPDPDL DPDLSRLLLG
       250        260        270        280        290        300
WAPGQPFSSC CPDTGKTQDE GARAGRLRAR RRYLVERARD ARVVGLLAGT LGVAQHREAL
       310        320        330        340        350        360
AHLRNLTQAA GKRSYVLALG RPTPAKLANF PEVDVFVLLA CPLGALAPQL SGSFFQPILA
       370        380        390        400        410        420
PCELEAACNP AWPPPGLAPH LTHYADLLPG SPFHVALPPP ESELWETPDV SLITGDLRPP
       430        440        450        460        470        480
PAWKSSNDHG SLALTPRPQL ELAESSPAAS FLSSRSWQGL EPRLGQTPVT EAVSGRRGIA

IAYEDEGSG

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BQC3-1-Acetylation	MESMFS...	1	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BQC3-1-Acetylation	MESMFS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BQC3-1-Acetylation	MESMFS...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BQC3-1-Acetylation	MESMFS...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt95967
Q9BQC3-1-unknown	MESMFS...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73181
Q9BQC3-254-unknown	TGKTQD...	254		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2320

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SCCPDT	253	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC2320
...DEGSG	489	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...DEGSG	489	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt68799
...DEGSG	489		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DEGSG	489		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...DEGSG	489		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...DEGSG	489		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP3_HUMAN	253	CPDT.\|.TGKT	inferred from experiment	unknown	MEROPS		Merops CASP3_HUMAN -> DPH2_HUMAN @253

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)