Q9BSQ5: Cerebral cavernous malformations 2 protein

General Information

Protein names	- Cerebral cavernous malformations 2 protein - Malcavernin {ECO:0000303\|PubMed:12853948}
Gene names	CCM2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BSQ5

2 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Malcavernin - Isoform 3 of Malcavernin - Isoform 4 of Malcavernin - Isoform 2 of Cerebral cavernous malformations 2 protein - Isoform 3 of Cerebral cavernous malformations 2 protein - Isoform 4 of Cerebral cavernous malformations 2 protein

Sequence View

        10         20         30         40         50         60
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS
        70         80         90        100        110        120
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQEHD AVLSLSAYNV
       130        140        150        160        170        180
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG
       190        200        210        220        230        240
SLSESAVGPV EACCLVILAA ESKVAAEELC CLLGQVFQVV YTESTIDFLD RAIFDGASTP
       250        260        270        280        290        300
THHLSLHSDD SSTKVDIKET YEVEASTFCF PESVDVGGAS PHSKTISESE LSASATELLQ
       310        320        330        340        350        360
DYMLTLRTKL SSQEIQQFAA LLHEYRNGAS IHEFCINLRQ LYGDSRKFLL LGLRPFIPEK
       370        380        390        400        410        420
DSQHFENFLE TIGVKDGRGI ITDSFGRHRR ALSTTSSSTT NGNRATGSSD DRSAPSEGDE
       430        440
WDRMISDISS DIEALGCSMD QDSA         10         20         30         40         50         60
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS
        70         80         90        100        110        120
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQEHD AVLSLSAYNV
       130        140        150        160        170        180
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG
       190        200        210        220        230        240
SLSESAVGPV EACCLVILAA ESKVAAEELC CLLGQVFQVV YTESTIDFLD RAIFDGASTP
       250        260        270        280        290        300
THHLSLHSDD SSTKVDIKET YEVEASTFCF PESVDVGGAS PHSKTISESE LSASATELLQ
       310        320        330        340        350        360
DYMLTLRTKL SSQEIQQFAA LLHEYRNGAS IHEFCINLRQ LYGDSRKFLL LGLRPFIPEK
       370        380        390        400        410        420
DSQHFENFLE TIGVKDGRGI ITDSFGRHRR ALSTTSSSTT NGNRATGSSD DRSAPSEGDE
       430        440
WDRMISDISS DIEALGCSMD QDSA         10         20         30         40         50         60
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS
        70         80         90        100        110        120
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQEHD AVLSLSAYNV
       130        140        150        160        170        180
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG
       190        200        210        220        230        240
SLSESAVGPV EACCLVILAA ESKVAAEELC CLLGQVFQVV YTESTIDFLD RAIFDGASTP
       250        260        270        280        290        300
THHLSLHSDD SSTKVDIKET YEVEASTFCF PESVDVGGAS PHSKTISESE LSASATELLQ
       310        320        330        340        350        360
DYMLTLRTKL SSQEIQQFAA LLHEYRNGAS IHEFCINLRQ LYGDSRKFLL LGLRPFIPEK
       370        380        390        400        410        420
DSQHFENFLE TIGVKDGRGI ITDSFGRHRR ALSTTSSSTT NGNRATGSSD DRSAPSEGDE
       430        440
WDRMISDISS DIEALGCSMD QDSA         10         20         30         40         50         60
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS
        70         80         90        100        110        120
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQEHD AVLSLSAYNV
       130        140        150        160        170        180
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG
       190        200        210        220        230        240
SLSESAVGPV EACCLVILAA ESKVAAEELC CLLGQVFQVV YTESTIDFLD RAIFDGASTP
       250        260        270        280        290        300
THHLSLHSDD SSTKVDIKET YEVEASTFCF PESVDVGGAS PHSKTISESE LSASATELLQ
       310        320        330        340        350        360
DYMLTLRTKL SSQEIQQFAA LLHEYRNGAS IHEFCINLRQ LYGDSRKFLL LGLRPFIPEK
       370        380        390        400        410        420
DSQHFENFLE TIGVKDGRGI ITDSFGRHRR ALSTTSSSTT NGNRATGSSD DRSAPSEGDE
       430        440
WDRMISDISS DIEALGCSMD QDSA         10         20         30         40         50         60
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS
        70         80         90        100        110        120
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQEHD AVLSLSAYNV
       130        140        150        160        170        180
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG
       190        200        210        220        230        240
SLSESAVGPV EACCLVILAA ESKVAAEELC CLLGQVFQVV YTESTIDFLD RAIFDGASTP
       250        260        270        280        290        300
THHLSLHSDD SSTKVDIKET YEVEASTFCF PESVDVGGAS PHSKTISESE LSASATELLQ
       310        320        330        340        350        360
DYMLTLRTKL SSQEIQQFAA LLHEYRNGAS IHEFCINLRQ LYGDSRKFLL LGLRPFIPEK
       370        380        390        400        410        420
DSQHFENFLE TIGVKDGRGI ITDSFGRHRR ALSTTSSSTT NGNRATGSSD DRSAPSEGDE
       430        440
WDRMISDISS DIEALGCSMD QDSA         10         20         30         40         50         60
MEEEGKKGKK PGIVSPFKRV FLKGEKSRDK KAHEKVTERR PLHTVVLSLP ERVEPDRLLS
        70         80         90        100        110        120
DYIEKEVKYL GQLTSIPGYL NPSSRTEILH FIDNAKRAHQ LPGHLTQEHD AVLSLSAYNV
       130        140        150        160        170        180
KLAWRDGEDI ILRVPIHDIA AVSYVRDDAA HLVVLKTAQD PGISPSQSLC AESSRGLSAG
       190        200        210        220        230        240
SLSESAVGPV EACCLVILAA ESKVAAEELC CLLGQVFQVV YTESTIDFLD RAIFDGASTP
       250        260        270        280        290        300
THHLSLHSDD SSTKVDIKET YEVEASTFCF PESVDVGGAS PHSKTISESE LSASATELLQ
       310        320        330        340        350        360
DYMLTLRTKL SSQEIQQFAA LLHEYRNGAS IHEFCINLRQ LYGDSRKFLL LGLRPFIPEK
       370        380        390        400        410        420
DSQHFENFLE TIGVKDGRGI ITDSFGRHRR ALSTTSSSTT NGNRATGSSD DRSAPSEGDE
       430        440
WDRMISDISS DIEALGCSMD QDSA

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BSQ5-1-unknown	MEEEGK...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BSQ5-1-unknown	MEEEGK...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt69759
Q9BSQ5-1-acetylation	MEEEGK...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BSQ5-1-acetylation	MEEEGK...	1	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178867

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...DQDSA	444	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...DQDSA	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65377
...DQDSA	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65378
...DQDSA	444	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt65376

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

TopFIND

Q9BSQ5: Cerebral cavernous malformations 2 protein

General Information

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates