Q9BUX1: Glutathione-specific gamma-glutamylcyclotransferase 1 {ECO:0000303|PubMed:27913623}

General Information

Protein names	- Glutathione-specific gamma-glutamylcyclotransferase 1 {ECO:0000303\|PubMed:27913623} - Gamma-GCG 1 {ECO:0000303\|PubMed:27913623} - 4.3.2.7 {ECO:0000269\|PubMed:27913623} - Blocks Notch protein {ECO:0000303\|PubMed:22445366} - Botch {ECO:0000303\|PubMed:22445366} - Cation transport regulator-like protein 1 {ECO:0000303\|PubMed:19109178}
Gene names	CHAC1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BUX1

3 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Cation transport regulator-like protein 1 - Isoform 2 of Glutathione-specific gamma-glutamylcyclotransferase 1

Sequence View

        10         20         30         40         50         60
MKQESAAPNT PPTSQSPTPS AQFPRNDGDP QALWIFGYGS LVWRPDFAYS DSRVGFVRGY
        70         80         90        100        110        120
SRRFWQGDTF HRGSDKMPGR VVTLLEDHEG CTWGVAYQVQ GEQVSKALKY LNVREAVLGG
       130        140        150        160        170        180
YDTKEVTFYP QDAPDQPLKA LAYVATPQNP GYLGPAPEEA IATQILACRG FSGHNLEYLL
       190        200        210        220
RLADFMQLCG PQAQDEHLAA IVDAVGTMLP CFCPTEQALA LV         10         20         30         40         50         60
MKQESAAPNT PPTSQSPTPS AQFPRNDGDP QALWIFGYGS LVWRPDFAYS DSRVGFVRGY
        70         80         90        100        110        120
SRRFWQGDTF HRGSDKMPGR VVTLLEDHEG CTWGVAYQVQ GEQVSKALKY LNVREAVLGG
       130        140        150        160        170        180
YDTKEVTFYP QDAPDQPLKA LAYVATPQNP GYLGPAPEEA IATQILACRG FSGHNLEYLL
       190        200        210        220
RLADFMQLCG PQAQDEHLAA IVDAVGTMLP CFCPTEQALA LV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BUX1-1-unknown	MKQESA...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BUX1-1-unknown	MKQESA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt70496
Q9BUX1-1-unknown	MKQESA...	1		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9BUX1-1-unknown	MKQESA...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168364
Q9BUX1-43-unknown	WRPDFA...	43	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt168364
Q9BUX1-43-	WRPDFA...	43		Subtiligase Based Positive Selection		Wells	apoptotic_Jurkat_bortezomib	23264352
Q9BUX1-43-	WRPDFA...	43		Subtiligase Based Positive Selection		Wells	apoptosis_U266_bortezomib_induced	23264352

C-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
	...	264	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
	...	264	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt66114

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)