Q9BV36: Melanophilin

General Information

Protein names	- Melanophilin - Exophilin-3 - Slp homolog lacking C2 domains a - SlaC2-a - Synaptotagmin-like protein 2a
Gene names	MLPH
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BV36

3 N-termini

4 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Melanophilin - Isoform 3 of Melanophilin - Isoform 4 of Melanophilin - Isoform 5 of Melanophilin

Sequence View

        10         20         30         40         50         60
MGKKLDLSKL TDEEAQHVLE VVQRDFDLRR KEEERLEALK GKIKKESSKR ELLSDTAHLN
        70         80         90        100        110        120
ETHCARCLQP YQLLVNSKRQ CLECGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW
       130        140        150        160        170        180
YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PELISEERSG DSDQTDEDGE PGSEAQAQAQ
       190        200        210        220        230        240
PFGSKKKRLL SVHDFDFEGD SDDSTQPQGH SLHLSSVPEA RDSPQSLTDE SCSEKAAPHK
       250        260        270        280        290        300
AEGLEEADTG ASGCHSHPEE QPTSISPSRH GALAELCPPG GSHRMALGTA AALGSNVIRN
       310        320        330        340        350        360
EQLPLQYLAD VDTSDEESIR AHVMASHHSK RRGRASSESQ IFELNKHISA VECLLTYLEN
       370        380        390        400        410        420
TVVPPLAKGL GAGVRTEADV EEEALRRKLE ELTSNVSDQE TSSEEEEAKD EKAEPNRDKS
       430        440        450        460        470        480
VGPLPQADPE VGTAAHQTNR QEKSPQDPGD PVQYNRTTDE ELSELEDRVA VTASEVQQAE
       490        500        510        520        530        540
SEVSDIESRI AALRAAGLTV KPSGKPRRKS NLPIFLPRVA GKLGKRPEDP NADPSSEAKA
       550        560        570        580        590        600
MAVPYLLRRK FSNSLKSQGK DDDSFDRKSV YRGSLTQRNP NARKGMASHT FAKPVVAHQS

        10         20         30         40         50         60
MGKKLDLSKL TDEEAQHVLE VVQRDFDLRR KEEERLEALK GKIKKESSKR ELLSDTAHLN
        70         80         90        100        110        120
ETHCARCLQP YQLLVNSKRQ CLECGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW
       130        140        150        160        170        180
YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PELISEERSG DSDQTDEDGE PGSEAQAQAQ
       190        200        210        220        230        240
PFGSKKKRLL SVHDFDFEGD SDDSTQPQGH SLHLSSVPEA RDSPQSLTDE SCSEKAAPHK
       250        260        270        280        290        300
AEGLEEADTG ASGCHSHPEE QPTSISPSRH GALAELCPPG GSHRMALGTA AALGSNVIRN
       310        320        330        340        350        360
EQLPLQYLAD VDTSDEESIR AHVMASHHSK RRGRASSESQ IFELNKHISA VECLLTYLEN
       370        380        390        400        410        420
TVVPPLAKGL GAGVRTEADV EEEALRRKLE ELTSNVSDQE TSSEEEEAKD EKAEPNRDKS
       430        440        450        460        470        480
VGPLPQADPE VGTAAHQTNR QEKSPQDPGD PVQYNRTTDE ELSELEDRVA VTASEVQQAE
       490        500        510        520        530        540
SEVSDIESRI AALRAAGLTV KPSGKPRRKS NLPIFLPRVA GKLGKRPEDP NADPSSEAKA
       550        560        570        580        590        600
MAVPYLLRRK FSNSLKSQGK DDDSFDRKSV YRGSLTQRNP NARKGMASHT FAKPVVAHQS

        10         20         30         40         50         60
MGKKLDLSKL TDEEAQHVLE VVQRDFDLRR KEEERLEALK GKIKKESSKR ELLSDTAHLN
        70         80         90        100        110        120
ETHCARCLQP YQLLVNSKRQ CLECGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW
       130        140        150        160        170        180
YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PELISEERSG DSDQTDEDGE PGSEAQAQAQ
       190        200        210        220        230        240
PFGSKKKRLL SVHDFDFEGD SDDSTQPQGH SLHLSSVPEA RDSPQSLTDE SCSEKAAPHK
       250        260        270        280        290        300
AEGLEEADTG ASGCHSHPEE QPTSISPSRH GALAELCPPG GSHRMALGTA AALGSNVIRN
       310        320        330        340        350        360
EQLPLQYLAD VDTSDEESIR AHVMASHHSK RRGRASSESQ IFELNKHISA VECLLTYLEN
       370        380        390        400        410        420
TVVPPLAKGL GAGVRTEADV EEEALRRKLE ELTSNVSDQE TSSEEEEAKD EKAEPNRDKS
       430        440        450        460        470        480
VGPLPQADPE VGTAAHQTNR QEKSPQDPGD PVQYNRTTDE ELSELEDRVA VTASEVQQAE
       490        500        510        520        530        540
SEVSDIESRI AALRAAGLTV KPSGKPRRKS NLPIFLPRVA GKLGKRPEDP NADPSSEAKA
       550        560        570        580        590        600
MAVPYLLRRK FSNSLKSQGK DDDSFDRKSV YRGSLTQRNP NARKGMASHT FAKPVVAHQS

        10         20         30         40         50         60
MGKKLDLSKL TDEEAQHVLE VVQRDFDLRR KEEERLEALK GKIKKESSKR ELLSDTAHLN
        70         80         90        100        110        120
ETHCARCLQP YQLLVNSKRQ CLECGLFTCK SCGRVHPEEQ GWICDPCHLA RVVKIGSLEW
       130        140        150        160        170        180
YYEHVKARFK RFGSAKVIRS LHGRLQGGAG PELISEERSG DSDQTDEDGE PGSEAQAQAQ
       190        200        210        220        230        240
PFGSKKKRLL SVHDFDFEGD SDDSTQPQGH SLHLSSVPEA RDSPQSLTDE SCSEKAAPHK
       250        260        270        280        290        300
AEGLEEADTG ASGCHSHPEE QPTSISPSRH GALAELCPPG GSHRMALGTA AALGSNVIRN
       310        320        330        340        350        360
EQLPLQYLAD VDTSDEESIR AHVMASHHSK RRGRASSESQ IFELNKHISA VECLLTYLEN
       370        380        390        400        410        420
TVVPPLAKGL GAGVRTEADV EEEALRRKLE ELTSNVSDQE TSSEEEEAKD EKAEPNRDKS
       430        440        450        460        470        480
VGPLPQADPE VGTAAHQTNR QEKSPQDPGD PVQYNRTTDE ELSELEDRVA VTASEVQQAE
       490        500        510        520        530        540
SEVSDIESRI AALRAAGLTV KPSGKPRRKS NLPIFLPRVA GKLGKRPEDP NADPSSEAKA
       550        560        570        580        590        600
MAVPYLLRRK FSNSLKSQGK DDDSFDRKSV YRGSLTQRNP NARKGMASHT FAKPVVAHQS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 4 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9BV36-1-unknown	MGKKLD...	1	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9BV36-1-unknown	MGKKLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80878
Q9BV36-1-unknown	MGKKLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80879
Q9BV36-1-unknown	MGKKLD...	1	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt80880
Q9BV36-2-unknown	GKKLDL...	2		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9BV36-2-unknown	GKKLDL...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178872
Q9BV36-2-unknown	GKKLDL...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178873
Q9BV36-2-unknown	GKKLDL...	2	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt178874
Q9BV36-452-unknown	VQYNRT...	452	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000399081
Q9BV36-452-unknown	VQYNRT...	452	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199547
Q9BV36-452-unknown	VQYNRT...	452	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt199546

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...RCLQPY	70	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000403909
...RCLQPY	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154042
...RCLQPY	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154043
...RCLQPY	70	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154044
...ARFKRF	131	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000409170
...ARFKRF	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154735
...ARFKRF	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154736
...ARFKRF	131	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154737
...QAESEV	482	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000405337
...VAHQS	600	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...VAHQS	600	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76497
...VAHQS	600	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt76496

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)