TopFIND 4.0

Q9BV94: ER degradation-enhancing alpha-mannosidase-like protein 2

General Information

Protein names
- ER degradation-enhancing alpha-mannosidase-like protein 2
Gene names EDEM2
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9BV94

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPFRLLIPLG LLCALLPQHH GAPGPDGSAP DPAHYRERVK AMFYHAYDSY LENAFPFDEL 
        70         80         90        100        110        120 
RPLTCDGHDT WGSFSLTLID ALDTLLILGN VSEFQRVVEV LQDSVDFDID VNASVFETNI 
       130        140        150        160        170        180 
RVVGGLLSAH LLSKKAGVEV EAGWPCSGPL LRMAEEAARK LLPAFQTPTG MPYGTVNLLH 
       190        200        210        220        230        240 
GVNPGETPVT CTAGIGTFIV EFATLSSLTG DPVFEDVARV ALMRLWESRS DIGLVGNHID 
       250        260        270        280        290        300 
VLTGKWVAQD AGIGAGVDSY FEYLVKGAIL LQDKKLMAMF LEYNKAIRNY TRFDDWYLWV 
       310        320        330        340        350        360 
QMYKGTVSMP VFQSLEAYWP GLQSLIGDID NAMRTFLNYY TVWKQFGGLP EFYNIPQGYT 
       370        380        390        400        410        420 
VEKREGYPLR PELIESAMYL YRATGDPTLL ELGRDAVESI EKISKVECGF ATIKDLRDHK 
       430        440        450        460        470        480 
LDNRMESFFL AETVKYLYLL FDPTNFIHNN GSTFDAVITP YGECILGAGG YIFNTEAHPI 
       490        500        510        520        530        540 
DPAALHCCQR LKEEQWEVED LMREFYSLKR SRSKFQKNTV SSGPWEPPAR PGTLFSPENH 
       550        560        570    
DQARERKPAK QKVPLLSCPS QPFTSKLALL GQVFLDSS

Isoforms

- Isoform 2 of ER degradation-enhancing alpha-mannosidase-like protein 2

Sequence View

        10         20         30         40         50         60 
MPFRLLIPLG LLCALLPQHH GAPGPDGSAP DPAHYRERVK AMFYHAYDSY LENAFPFDEL 
        70         80         90        100        110        120 
RPLTCDGHDT WGSFSLTLID ALDTLLILGN VSEFQRVVEV LQDSVDFDID VNASVFETNI 
       130        140        150        160        170        180 
RVVGGLLSAH LLSKKAGVEV EAGWPCSGPL LRMAEEAARK LLPAFQTPTG MPYGTVNLLH 
       190        200        210        220        230        240 
GVNPGETPVT CTAGIGTFIV EFATLSSLTG DPVFEDVARV ALMRLWESRS DIGLVGNHID 
       250        260        270        280        290        300 
VLTGKWVAQD AGIGAGVDSY FEYLVKGAIL LQDKKLMAMF LEYNKAIRNY TRFDDWYLWV 
       310        320        330        340        350        360 
QMYKGTVSMP VFQSLEAYWP GLQSLIGDID NAMRTFLNYY TVWKQFGGLP EFYNIPQGYT 
       370        380        390        400        410        420 
VEKREGYPLR PELIESAMYL YRATGDPTLL ELGRDAVESI EKISKVECGF ATIKDLRDHK 
       430        440        450        460        470        480 
LDNRMESFFL AETVKYLYLL FDPTNFIHNN GSTFDAVITP YGECILGAGG YIFNTEAHPI 
       490        500        510        520        530        540 
DPAALHCCQR LKEEQWEVED LMREFYSLKR SRSKFQKNTV SSGPWEPPAR PGTLFSPENH 
       550        560        570    
DQARERKPAK QKVPLLSCPS QPFTSKLALL GQVFLDSS



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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9BV94-1-unknown MPFRLL... 1 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73629
    Q9BV94-22-unknown APGPDG... 22 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...FLDSS 578 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...FLDSS 578 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt69247

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)