Q9BY41: Histone deacetylase 8

General Information

Protein names	- Histone deacetylase 8 - HD8 - 3.5.1.98
Gene names	HDAC8
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9BY41

1 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Histone deacetylase 8 - Isoform 3 of Histone deacetylase 8 - Isoform 4 of Histone deacetylase 8 - Isoform 5 of Histone deacetylase 8 - Isoform 6 of Histone deacetylase 8 - Isoform 7 of Histone deacetylase 8 - Isoform 8 of Histone deacetylase 8

Sequence View

        10         20         30         40         50         60
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK
        70         80         90        100        110        120
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI
       130        140        150        160        170        180
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH
       190        200        210        220        230        240
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY
       250        260        270        280        290        300
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
       310        320        330        340        350        360
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH
       370
RIQQILNYIK GNLKHVV         10         20         30         40         50         60
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK
        70         80         90        100        110        120
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI
       130        140        150        160        170        180
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH
       190        200        210        220        230        240
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY
       250        260        270        280        290        300
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
       310        320        330        340        350        360
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH
       370
RIQQILNYIK GNLKHVV         10         20         30         40         50         60
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK
        70         80         90        100        110        120
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI
       130        140        150        160        170        180
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH
       190        200        210        220        230        240
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY
       250        260        270        280        290        300
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
       310        320        330        340        350        360
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH
       370
RIQQILNYIK GNLKHVV         10         20         30         40         50         60
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK
        70         80         90        100        110        120
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI
       130        140        150        160        170        180
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH
       190        200        210        220        230        240
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY
       250        260        270        280        290        300
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
       310        320        330        340        350        360
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH
       370
RIQQILNYIK GNLKHVV         10         20         30         40         50         60
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK
        70         80         90        100        110        120
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI
       130        140        150        160        170        180
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH
       190        200        210        220        230        240
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY
       250        260        270        280        290        300
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
       310        320        330        340        350        360
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH
       370
RIQQILNYIK GNLKHVV         10         20         30         40         50         60
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK
        70         80         90        100        110        120
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI
       130        140        150        160        170        180
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH
       190        200        210        220        230        240
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY
       250        260        270        280        290        300
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
       310        320        330        340        350        360
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH
       370
RIQQILNYIK GNLKHVV         10         20         30         40         50         60
MEEPEEPADS GQSLVPVYIY SPEYVSMCDS LAKIPKRASM VHSLIEAYAL HKQMRIVKPK
        70         80         90        100        110        120
VASMEEMATF HTDAYLQHLQ KVSQEGDDDH PDSIEYGLGY DCPATEGIFD YAAAIGGATI
       130        140        150        160        170        180
TAAQCLIDGM CKVAINWSGG WHHAKKDEAS GFCYLNDAVL GILRLRRKFE RILYVDLDLH
       190        200        210        220        230        240
HGDGVEDAFS FTSKVMTVSL HKFSPGFFPG TGDVSDVGLG KGRYYSVNVP IQDGIQDEKY
       250        260        270        280        290        300
YQICESVLKE VYQAFNPKAV VLQLGADTIA GDPMCSFNMT PVGIGKCLKY ILQWQLATLI
       310        320        330        340        350        360
LGGGGYNLAN TARCWTYLTG VILGKTLSSE IPDHEFFTAY GPDYVLEITP SCRPDRNEPH
       370
RIQQILNYIK GNLKHVV

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

1 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9BY41-1-unknown	MEEPEE...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9BY41-1-unknown	MEEPEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76819
Q9BY41-1-unknown	MEEPEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76820
Q9BY41-1-unknown	MEEPEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76821
Q9BY41-1-unknown	MEEPEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76822
Q9BY41-1-unknown	MEEPEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76823
Q9BY41-1-unknown	MEEPEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76824
Q9BY41-1-unknown	MEEPEE...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76825

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...HHAKKD	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72443
...HHAKKD	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91698
...HHAKKD	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91699
...HHAKKD	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91700
...HHAKKD	146	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt91701
...LKHVV	377	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...LKHVV	377	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72439

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)