TopFIND 4.0

Q9BZG8: 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 {ECO:0000305}

General Information

Protein names
- 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 {ECO:0000305}
- 2.5.1.108 {ECO:0000250|UniProtKB:Q5NCQ5}
- Diphthamide biosynthesis protein 1
- Diphtheria toxin resistance protein 1 {ECO:0000305}
- Ovarian cancer-associated gene 1 protein
- S-adenosyl-L-methionine:L-histidine 3-amino-3-carboxypropyltransferase 1 {ECO:0000305}
Gene names DPH1
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9BZG8

3

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MRRQVMAALV VSGAAEQGGR DGPGRGRAPR GRVANQIPPE ILKNPQLQAA IRVLPSNYNF 
        70         80         90        100        110        120 
EIPKTIWRIQ QAQAKKVALQ MPEGLLLFAC TIVDILERFT EAEVMVMGDV TYGACCVDDF 
       130        140        150        160        170        180 
TARALGADFL VHYGHSCLIP MDTSAQDFRV LYVFVDIRID TTHLLDSLRL TFPPATALAL 
       190        200        210        220        230        240 
VSTIQFVSTL QAAAQELKAE YRVSVPQCKP LSPGEILGCT SPRLSKEVEA VVYLGDGRFH 
       250        260        270        280        290        300 
LESVMIANPN VPAYRYDPYS KVLSREHYDH QRMQAARQEA IATARSAKSW GLILGTLGRQ 
       310        320        330        340        350        360 
GSPKILEHLE SRLRALGLSF VRLLLSEIFP SKLSLLPEVD VWVQVACPRL SIDWGTAFPK 
       370        380        390        400        410        420 
PLLTPYEAAV ALRDISWQQP YPMDFYAGSS LGPWTVNHGQ DRRPHAPGRP ARGKVQEGSA 
       430        440    
RPPSAVACED CSCRDEKVAP LAP

Isoforms

- Isoform 2 of Diphthamide biosynthesis protein 1 - Isoform 3 of Diphthamide biosynthesis protein 1 - Isoform 2 of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 - Isoform 3 of 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

Sequence View

        10         20         30         40         50         60 
MRRQVMAALV VSGAAEQGGR DGPGRGRAPR GRVANQIPPE ILKNPQLQAA IRVLPSNYNF 
        70         80         90        100        110        120 
EIPKTIWRIQ QAQAKKVALQ MPEGLLLFAC TIVDILERFT EAEVMVMGDV TYGACCVDDF 
       130        140        150        160        170        180 
TARALGADFL VHYGHSCLIP MDTSAQDFRV LYVFVDIRID TTHLLDSLRL TFPPATALAL 
       190        200        210        220        230        240 
VSTIQFVSTL QAAAQELKAE YRVSVPQCKP LSPGEILGCT SPRLSKEVEA VVYLGDGRFH 
       250        260        270        280        290        300 
LESVMIANPN VPAYRYDPYS KVLSREHYDH QRMQAARQEA IATARSAKSW GLILGTLGRQ 
       310        320        330        340        350        360 
GSPKILEHLE SRLRALGLSF VRLLLSEIFP SKLSLLPEVD VWVQVACPRL SIDWGTAFPK 
       370        380        390        400        410        420 
PLLTPYEAAV ALRDISWQQP YPMDFYAGSS LGPWTVNHGQ DRRPHAPGRP ARGKVQEGSA 
       430        440    
RPPSAVACED CSCRDEKVAP LAP         10         20         30         40         50         60 
MRRQVMAALV VSGAAEQGGR DGPGRGRAPR GRVANQIPPE ILKNPQLQAA IRVLPSNYNF 
        70         80         90        100        110        120 
EIPKTIWRIQ QAQAKKVALQ MPEGLLLFAC TIVDILERFT EAEVMVMGDV TYGACCVDDF 
       130        140        150        160        170        180 
TARALGADFL VHYGHSCLIP MDTSAQDFRV LYVFVDIRID TTHLLDSLRL TFPPATALAL 
       190        200        210        220        230        240 
VSTIQFVSTL QAAAQELKAE YRVSVPQCKP LSPGEILGCT SPRLSKEVEA VVYLGDGRFH 
       250        260        270        280        290        300 
LESVMIANPN VPAYRYDPYS KVLSREHYDH QRMQAARQEA IATARSAKSW GLILGTLGRQ 
       310        320        330        340        350        360 
GSPKILEHLE SRLRALGLSF VRLLLSEIFP SKLSLLPEVD VWVQVACPRL SIDWGTAFPK 
       370        380        390        400        410        420 
PLLTPYEAAV ALRDISWQQP YPMDFYAGSS LGPWTVNHGQ DRRPHAPGRP ARGKVQEGSA 
       430        440    
RPPSAVACED CSCRDEKVAP LAP         10         20         30         40         50         60 
MRRQVMAALV VSGAAEQGGR DGPGRGRAPR GRVANQIPPE ILKNPQLQAA IRVLPSNYNF 
        70         80         90        100        110        120 
EIPKTIWRIQ QAQAKKVALQ MPEGLLLFAC TIVDILERFT EAEVMVMGDV TYGACCVDDF 
       130        140        150        160        170        180 
TARALGADFL VHYGHSCLIP MDTSAQDFRV LYVFVDIRID TTHLLDSLRL TFPPATALAL 
       190        200        210        220        230        240 
VSTIQFVSTL QAAAQELKAE YRVSVPQCKP LSPGEILGCT SPRLSKEVEA VVYLGDGRFH 
       250        260        270        280        290        300 
LESVMIANPN VPAYRYDPYS KVLSREHYDH QRMQAARQEA IATARSAKSW GLILGTLGRQ 
       310        320        330        340        350        360 
GSPKILEHLE SRLRALGLSF VRLLLSEIFP SKLSLLPEVD VWVQVACPRL SIDWGTAFPK 
       370        380        390        400        410        420 
PLLTPYEAAV ALRDISWQQP YPMDFYAGSS LGPWTVNHGQ DRRPHAPGRP ARGKVQEGSA 
       430        440    
RPPSAVACED CSCRDEKVAP LAP         10         20         30         40         50         60 
MRRQVMAALV VSGAAEQGGR DGPGRGRAPR GRVANQIPPE ILKNPQLQAA IRVLPSNYNF 
        70         80         90        100        110        120 
EIPKTIWRIQ QAQAKKVALQ MPEGLLLFAC TIVDILERFT EAEVMVMGDV TYGACCVDDF 
       130        140        150        160        170        180 
TARALGADFL VHYGHSCLIP MDTSAQDFRV LYVFVDIRID TTHLLDSLRL TFPPATALAL 
       190        200        210        220        230        240 
VSTIQFVSTL QAAAQELKAE YRVSVPQCKP LSPGEILGCT SPRLSKEVEA VVYLGDGRFH 
       250        260        270        280        290        300 
LESVMIANPN VPAYRYDPYS KVLSREHYDH QRMQAARQEA IATARSAKSW GLILGTLGRQ 
       310        320        330        340        350        360 
GSPKILEHLE SRLRALGLSF VRLLLSEIFP SKLSLLPEVD VWVQVACPRL SIDWGTAFPK 
       370        380        390        400        410        420 
PLLTPYEAAV ALRDISWQQP YPMDFYAGSS LGPWTVNHGQ DRRPHAPGRP ARGKVQEGSA 
       430        440    
RPPSAVACED CSCRDEKVAP LAP



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Evidence Codes:


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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

3 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9BZG8-1-unknown MRRQVM... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9BZG8-81-unknown MPEGLL... 81 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73179
    Q9BZG8-141-unknown MDTSAQ... 141 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt73180
    Q9BZG8-141-unknown MDTSAQ... 141 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt108138

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)