Q9BZZ2: Sialoadhesin
| Protein names | - Sialoadhesin - Sialic acid-binding Ig-like lectin 1 - Siglec-1 - CD169 |
|---|---|
| Gene names | SIGLEC1 |
| Organism | Homo sapiens |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q9BZZ2 |
2
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY
70 80 90 100 110 120
YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS
130 140 150 160 170 180
EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP
190 200 210 220 230 240
ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG
250 260 270 280 290 300
VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA
310 320 330 340 350 360
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW
370 380 390 400 410 420
YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF
430 440 450 460 470 480
LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD
490 500 510 520 530 540
LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD
550 560 570 580 590 600
ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ
610 620 630 640 650 660
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS
670 680 690 700 710 720
PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ
730 740 750 760 770 780
EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA
790 800 810 820 830 840
GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL
850 860 870 880 890 900
GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV
910 920 930 940 950 960
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC
970 980 990 1000 1010 1020
QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG
1030 1040 1050 1060 1070 1080
DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA
1090 1100 1110 1120 1130 1140
DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT
1150 1160 1170 1180 1190 1200
VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP
1210 1220 1230 1240 1250 1260
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG
1270 1280 1290 1300 1310 1320
VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG
1330 1340 1350 1360 1370 1380
AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS
1390 1400 1410 1420 1430 1440
HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL
1450 1460 1470 1480 1490 1500
QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH
1510 1520 1530 1540 1550 1560
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP
1570 1580 1590 1600 1610 1620
LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG
1630 1640 1650 1660 1670 1680
SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV
1690 1700
EMAFQKETTQ LIDPDAATCE TSTCAPPLG
Isoforms
- Isoform 2 of Sialoadhesin - Isoform 3 of SialoadhesinSequence View
10 20 30 40 50 60
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY
70 80 90 100 110 120
YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS
130 140 150 160 170 180
EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP
190 200 210 220 230 240
ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG
250 260 270 280 290 300
VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA
310 320 330 340 350 360
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW
370 380 390 400 410 420
YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF
430 440 450 460 470 480
LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD
490 500 510 520 530 540
LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD
550 560 570 580 590 600
ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ
610 620 630 640 650 660
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS
670 680 690 700 710 720
PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ
730 740 750 760 770 780
EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA
790 800 810 820 830 840
GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL
850 860 870 880 890 900
GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV
910 920 930 940 950 960
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC
970 980 990 1000 1010 1020
QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG
1030 1040 1050 1060 1070 1080
DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA
1090 1100 1110 1120 1130 1140
DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT
1150 1160 1170 1180 1190 1200
VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP
1210 1220 1230 1240 1250 1260
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG
1270 1280 1290 1300 1310 1320
VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG
1330 1340 1350 1360 1370 1380
AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS
1390 1400 1410 1420 1430 1440
HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL
1450 1460 1470 1480 1490 1500
QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH
1510 1520 1530 1540 1550 1560
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP
1570 1580 1590 1600 1610 1620
LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG
1630 1640 1650 1660 1670 1680
SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV
1690 1700
EMAFQKETTQ LIDPDAATCE TSTCAPPLG
10 20 30 40 50 60
MGFLPKLLLL ASFFPAGQAS WGVSSPQDVQ GVKGSCLLIP CIFSFPADVE VPDGITAIWY
70 80 90 100 110 120
YDYSGQRQVV SHSADPKLVE ARFRGRTEFM GNPEHRVCNL LLKDLQPEDS GSYNFRFEIS
130 140 150 160 170 180
EVNRWSDVKG TLVTVTEEPR VPTIASPVEL LEGTEVDFNC STPYVCLQEQ VRLQWQGQDP
190 200 210 220 230 240
ARSVTFNSQK FEPTGVGHLE TLHMAMSWQD HGRILRCQLS VANHRAQSEI HLQVKYAPKG
250 260 270 280 290 300
VKILLSPSGR NILPGELVTL TCQVNSSYPA VSSIKWLKDG VRLQTKTGVL HLPQAAWSDA
310 320 330 340 350 360
GVYTCQAENG VGSLVSPPIS LHIFMAEVQV SPAGPILENQ TVTLVCNTPN EAPSDLRYSW
370 380 390 400 410 420
YKNHVLLEDA HSHTLRLHLA TRADTGFYFC EVQNVHGSER SGPVSVVVNH PPLTPVLTAF
430 440 450 460 470 480
LETQAGLVGI LHCSVVSEPL ATLVLSHGGH ILASTSGDSD HSPRFSGTSG PNSLRLEIRD
490 500 510 520 530 540
LEETDSGEYK CSATNSLGNA TSTLDFHANA ARLLISPAAE VVEGQAVTLS CRSGLSPTPD
550 560 570 580 590 600
ARFSWYLNGA LLHEGPGSSL LLPAASSTDA GSYHCRARDG HSASGPSSPA VLTVLYPPRQ
610 620 630 640 650 660
PTFTTRLDLD AAGAGAGRRG LLLCRVDSDP PARLQLLHKD RVVATSLPSG GGCSTCGGCS
670 680 690 700 710 720
PRMKVTKAPN LLRVEIHNPL LEEEGLYLCE ASNALGNAST SATFNGQATV LAIAPSHTLQ
730 740 750 760 770 780
EGTEANLTCN VSREAAGSPA NFSWFRNGVL WAQGPLETVT LLPVARTDAA LYACRILTEA
790 800 810 820 830 840
GAQLSTPVLL SVLYPPDRPK LSALLDMGQG HMALFICTVD SRPLALLALF HGEHLLATSL
850 860 870 880 890 900
GPQVPSHGRF QAKAEANSLK LEVRELGLGD SGSYRCEATN VLGSSNTSLF FQVRGAWVQV
910 920 930 940 950 960
SPSPELQEGQ AVVLSCQVHT GVPEGTSYRW YRDGQPLQES TSATLRFAAI TLTQAGAYHC
970 980 990 1000 1010 1020
QAQAPGSATT SLAAPISLHV SYAPRHVTLT TLMDTGPGRL GLLLCRVDSD PPAQLRLLHG
1030 1040 1050 1060 1070 1080
DRLVASTLQG VGGPEGSSPR LHVAVAPNTL RLEIHGAMLE DEGVYICEAS NTLGQASASA
1090 1100 1110 1120 1130 1140
DFDAQAVNVQ VWPGATVREG QLVNLTCLVW TTHPAQLTYT WYQDGQQRLD AHSIPLPNVT
1150 1160 1170 1180 1190 1200
VRDATSYRCG VGPPGRAPRL SRPITLDVLY APRNLRLTYL LESHGGQLAL VLCTVDSRPP
1210 1220 1230 1240 1250 1260
AQLALSHAGR LLASSTAASV PNTLRLELRG PQPRDEGFYS CSARSPLGQA NTSLELRLEG
1270 1280 1290 1300 1310 1320
VRVILAPEAA VPEGAPITVT CADPAAHAPT LYTWYHNGRW LQEGPAASLS FLVATRAHAG
1330 1340 1350 1360 1370 1380
AYSCQAQDAQ GTRSSRPAAL QVLYAPQDAV LSSFRDSRAR SMAVIQCTVD SEPPAELALS
1390 1400 1410 1420 1430 1440
HDGKVLATSS GVHSLASGTG HVQVARNALR LQVQDVPAGD DTYVCTAQNL LGSISTIGRL
1450 1460 1470 1480 1490 1500
QVEGARVVAE PGLDVPEGAA LNLSCRLLGG PGPVGNSTFA WFWNDRRLHA EPVPTLAFTH
1510 1520 1530 1540 1550 1560
VARAQAGMYH CLAELPTGAA ASAPVMLRVL YPPKTPTMMV FVEPEGGLRG ILDCRVDSEP
1570 1580 1590 1600 1610 1620
LASLTLHLGS RLVASSQPQG APAEPHIHVL ASPNALRVDI EALRPSDQGE YICSASNVLG
1630 1640 1650 1660 1670 1680
SASTSTYFGV RALHRLHQFQ QLLWVLGLLV GLLLLLLGLG ACYTWRRRRV CKQSMGENSV
1690 1700
EMAFQKETTQ LIDPDAATCE TSTCAPPLG
Protein Neighborhood
Domains & Features
2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q9BZZ2-1-unknown | MGFLPK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt90200 | |||
| Q9BZZ2-1-unknown | MGFLPK... | 1 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt90201 | |||
| Q9BZZ2-20-unknown | SWGVSS... | 20 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| Q9BZZ2-20-unknown | SWGVSS... | 20 | inferred from similarity | unknown | UniProtKB | inferred from uniprot (by similarity) | |||
| Q9BZZ2-20-unknown | SWGVSS... | 20 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt112282 | |||
| Q9BZZ2-20-unknown | SWGVSS... | 20 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TNt112283 |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...APPLG | 1709 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|