TopFIND 4.0

Q9C0B1: Alpha-ketoglutarate-dependent dioxygenase FTO {ECO:0000305}

General Information

Protein names
- Alpha-ketoglutarate-dependent dioxygenase FTO {ECO:0000305}
- Fat mass and obesity-associated protein {ECO:0000303|PubMed:17496892}
- U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000269|PubMed:30197295}
- U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000269|PubMed:30197295}
- mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO {ECO:0000305}
- m6A(m)-demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000269|PubMed:28002401, ECO:0000269|PubMed:30197295}
- mRNA N(6)-methyladenosine demethylase FTO {ECO:0000305}
- 1.14.11.53 {ECO:0000269|PubMed:25452335, ECO:0000269|PubMed:26457839, ECO:0000269|PubMed:30197295, ECO:0000305|PubMed:22002720}
- tRNA N1-methyl adenine demethylase FTO {ECO:0000305}
- 1.14.11.- {ECO:0000269|PubMed:30197295}
Gene names FTO
Organism Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID Q9C0B1

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI LREASSVSEE 
        70         80         90        100        110        120 
LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG NPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGSNIKHTEA EIAAACETFL KLNDYLQIET IQALEELAAK EKANEDAVPL CMSADFPRVG 
       190        200        210        220        230        240 
MGSSYNGQDE VDIKSRAAYN VTLLNFMDPQ KMPYLKEEPY FGMGKMAVSW HHDENLVDRS 
       250        260        270        280        290        300 
AVAVYSYSCE GPEEESEDDS HLEGRDPDIW HVGFKISWDI ETPGLAIPLH QGDCYFMLDD 
       310        320        330        340        350        360 
LNATHQHCVL AGSQPRFSST HRVAECSTGT LDYILQRCQL ALQNVCDDVD NDDVSLKSFE 
       370        380        390        400        410        420 
PAVLKQGEEI HNEVEFEWLR QFWFQGNRYR KCTDWWCQPM AQLEALWKKM EGVTNAVLHE 
       430        440        450        460        470        480 
VKREGLPVEQ RNEILTAILA SLTARQNLRR EWHARCQSRI ARTLPADQKP ECRPYWEKDD 
       490        500    
ASMPLPFDLT DIVSELRGQL LEAKP

Isoforms

- Isoform 2 of Alpha-ketoglutarate-dependent dioxygenase FTO - Isoform 3 of Alpha-ketoglutarate-dependent dioxygenase FTO - Isoform 4 of Alpha-ketoglutarate-dependent dioxygenase FTO

Sequence View

        10         20         30         40         50         60 
MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI LREASSVSEE 
        70         80         90        100        110        120 
LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG NPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGSNIKHTEA EIAAACETFL KLNDYLQIET IQALEELAAK EKANEDAVPL CMSADFPRVG 
       190        200        210        220        230        240 
MGSSYNGQDE VDIKSRAAYN VTLLNFMDPQ KMPYLKEEPY FGMGKMAVSW HHDENLVDRS 
       250        260        270        280        290        300 
AVAVYSYSCE GPEEESEDDS HLEGRDPDIW HVGFKISWDI ETPGLAIPLH QGDCYFMLDD 
       310        320        330        340        350        360 
LNATHQHCVL AGSQPRFSST HRVAECSTGT LDYILQRCQL ALQNVCDDVD NDDVSLKSFE 
       370        380        390        400        410        420 
PAVLKQGEEI HNEVEFEWLR QFWFQGNRYR KCTDWWCQPM AQLEALWKKM EGVTNAVLHE 
       430        440        450        460        470        480 
VKREGLPVEQ RNEILTAILA SLTARQNLRR EWHARCQSRI ARTLPADQKP ECRPYWEKDD 
       490        500    
ASMPLPFDLT DIVSELRGQL LEAKP         10         20         30         40         50         60 
MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI LREASSVSEE 
        70         80         90        100        110        120 
LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG NPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGSNIKHTEA EIAAACETFL KLNDYLQIET IQALEELAAK EKANEDAVPL CMSADFPRVG 
       190        200        210        220        230        240 
MGSSYNGQDE VDIKSRAAYN VTLLNFMDPQ KMPYLKEEPY FGMGKMAVSW HHDENLVDRS 
       250        260        270        280        290        300 
AVAVYSYSCE GPEEESEDDS HLEGRDPDIW HVGFKISWDI ETPGLAIPLH QGDCYFMLDD 
       310        320        330        340        350        360 
LNATHQHCVL AGSQPRFSST HRVAECSTGT LDYILQRCQL ALQNVCDDVD NDDVSLKSFE 
       370        380        390        400        410        420 
PAVLKQGEEI HNEVEFEWLR QFWFQGNRYR KCTDWWCQPM AQLEALWKKM EGVTNAVLHE 
       430        440        450        460        470        480 
VKREGLPVEQ RNEILTAILA SLTARQNLRR EWHARCQSRI ARTLPADQKP ECRPYWEKDD 
       490        500    
ASMPLPFDLT DIVSELRGQL LEAKP         10         20         30         40         50         60 
MKRTPTAEER EREAKKLRLL EELEDTWLPY LTPKDDEFYQ QWQLKYPKLI LREASSVSEE 
        70         80         90        100        110        120 
LHKEVQEAFL TLHKHGCLFR DLVRIQGKDL LTPVSRILIG NPGCTYKYLN TRLFTVPWPV 
       130        140        150        160        170        180 
KGSNIKHTEA EIAAACETFL KLNDYLQIET IQALEELAAK EKANEDAVPL CMSADFPRVG 
       190        200        210        220        230        240 
MGSSYNGQDE VDIKSRAAYN VTLLNFMDPQ KMPYLKEEPY FGMGKMAVSW HHDENLVDRS 
       250        260        270        280        290        300 
AVAVYSYSCE GPEEESEDDS HLEGRDPDIW HVGFKISWDI ETPGLAIPLH QGDCYFMLDD 
       310        320        330        340        350        360 
LNATHQHCVL AGSQPRFSST HRVAECSTGT LDYILQRCQL ALQNVCDDVD NDDVSLKSFE 
       370        380        390        400        410        420 
PAVLKQGEEI HNEVEFEWLR QFWFQGNRYR KCTDWWCQPM AQLEALWKKM EGVTNAVLHE 
       430        440        450        460        470        480 
VKREGLPVEQ RNEILTAILA SLTARQNLRR EWHARCQSRI ARTLPADQKP ECRPYWEKDD 
       490        500    
ASMPLPFDLT DIVSELRGQL LEAKP



Filter Information:


(REFRESH)

Directness:


Physiological Relevance:


Evidence Codes:


Methodology:


Perturbation of System:


Biological System:


Protease Assignment Confidence:


Evidence Names:


Database:


Lab:



Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9C0B1-1-unknown MKRTPT... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9C0B1-400-unknown MAQLEA... 400 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt75522

C-termini

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)