TopFIND 4.0

Q9CWR0: Rho guanine nucleotide exchange factor 25

General Information

Protein names
- Rho guanine nucleotide exchange factor 25
- Guanine nucleotide exchange factor GEFT
- Rac/Cdc42/Rho exchange factor GEFT
- RhoA/Rac/Cdc42 guanine nucleotide exchange factor GEFT
- p63RhoGEF
Gene names Arhgef25
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q9CWR0

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MKPPDRPTPG RTDRILGVMG GMLRACAVPG QEGPPERDPL GPGSTKTESD CIEEDQTGQR 
        70         80         90        100        110        120 
EPEVLAWAPQ PESYSIAVSE GSMSASAVSG LAALSGPSSG LSSDPCSPIP PGPVTGLRRW 
       130        140        150        160        170        180 
LDHSKHCLSV ETEAESGQTG QCENWTLGPT LTTGQELPEL TLLTTLLEGP GDKAQPAEEE 
       190        200        210        220        230        240 
TLSQAPKNEE EQKKMALERS MFVLGELVET ERTYEDDLGQ IVEGYMATMA TQGVPESLRG 
       250        260        270        280        290        300 
RDRIVFGNIQ QIYEWHRDYF LQELQQCLKD PDWLAQLFIK HERRLHMYVV YCQNKPKSEH 
       310        320        330        340        350        360 
VLSEFGDSYF EELRQQLGHR LQLNDLLIKP VQRIMKYQLL LKDFLKYYRR AGKDTEELEQ 
       370        380        390        400        410        420 
AVEVMCFVPK RCNDMMSLGR LRGFEGKLTA QGKLLGQDTF LVTEPEAGGL LSSRGRERRV 
       430        440        450        460        470        480 
FLFEQIIIFS EALGGGGRGG AQPGYVYKNS IKVSCLGLEG NLQGNPCRFA LTSRGPEGGI 
       490        500        510        520        530        540 
QRYVLQASDP AVSQAWIKQV AQILESQRDF LNALQSPIEY QRRESQTNSL GRPGGPWVGS 
       550        560        570        580        590        600 
PGRMRPGDLA QASMHTPING SLPSLLLLPR GEVSRVLLPL DTQALSDTPQ TPHDSPALPT 
       610    
VNTPPCQARL AKLDEDEL

Isoforms

- Isoform 2 of Rho guanine nucleotide exchange factor 25

Sequence View

        10         20         30         40         50         60 
MKPPDRPTPG RTDRILGVMG GMLRACAVPG QEGPPERDPL GPGSTKTESD CIEEDQTGQR 
        70         80         90        100        110        120 
EPEVLAWAPQ PESYSIAVSE GSMSASAVSG LAALSGPSSG LSSDPCSPIP PGPVTGLRRW 
       130        140        150        160        170        180 
LDHSKHCLSV ETEAESGQTG QCENWTLGPT LTTGQELPEL TLLTTLLEGP GDKAQPAEEE 
       190        200        210        220        230        240 
TLSQAPKNEE EQKKMALERS MFVLGELVET ERTYEDDLGQ IVEGYMATMA TQGVPESLRG 
       250        260        270        280        290        300 
RDRIVFGNIQ QIYEWHRDYF LQELQQCLKD PDWLAQLFIK HERRLHMYVV YCQNKPKSEH 
       310        320        330        340        350        360 
VLSEFGDSYF EELRQQLGHR LQLNDLLIKP VQRIMKYQLL LKDFLKYYRR AGKDTEELEQ 
       370        380        390        400        410        420 
AVEVMCFVPK RCNDMMSLGR LRGFEGKLTA QGKLLGQDTF LVTEPEAGGL LSSRGRERRV 
       430        440        450        460        470        480 
FLFEQIIIFS EALGGGGRGG AQPGYVYKNS IKVSCLGLEG NLQGNPCRFA LTSRGPEGGI 
       490        500        510        520        530        540 
QRYVLQASDP AVSQAWIKQV AQILESQRDF LNALQSPIEY QRRESQTNSL GRPGGPWVGS 
       550        560        570        580        590        600 
PGRMRPGDLA QASMHTPING SLPSLLLLPR GEVSRVLLPL DTQALSDTPQ TPHDSPALPT 
       610    
VNTPPCQARL AKLDEDEL



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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9CWR0-1-unknown MKPPDR... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...DEDEL 618 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    ...DEDEL 618 inferred from isoform by sequence similarity unknown TopFIND inferred from TCt63048

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)