TopFIND 4.0

Q9D842: Aprataxin and PNK-like factor

General Information

Protein names
- Aprataxin and PNK-like factor
- 4.2.99.18 {ECO:0000250|UniProtKB:Q8IW19}
- Apurinic-apyrimidinic endonuclease APLF
Gene names Aplf
Organism Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID Q9D842

2

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MPSDFFLQPL DGGPRVPVGP GQTVIGRGPL LGITDKRVSR RHAILEVVDS QLRIKPIHRN 
        70         80         90        100        110        120 
PCFYQSSEKS QHSPMETQVW SQLHPGDSFS LLLDKYAFRV FSAESEVEME CTLRNSQMLD 
       130        140        150        160        170        180 
EDDILSEMQK SPVVNLPDKT TGASQLQGSP EITKTKCPTI DPMSSSGECR AFSEHQPRPT 
       190        200        210        220        230        240 
QRKRILPAWM LAESLSDQSL STPAEGGDKD VIQRSGKAGT CEDRTPGNTS WHGKKRLSPS 
       250        260        270        280        290        300 
GNSKSVSAEQ DPGKKCRKAD QEGPGVSSEN VPESSSSNIV KDPDVDIVKT NKQKDGILIE 
       310        320        330        340        350        360 
ELGEVSKHKA ATKPTTNEEG ESCARVQSKS PPEKSQGCHP ESSSAPSSPD ALHTDTADPV 
       370        380        390        400        410        420 
LGCSEESKVR RTACMYGANC YRRNPLHFQH FSHPGDSDYG EVHGTDEGVI GDRPECPYGA 
       430        440        450        460        470        480 
SCYRKNPQHK MEYRHSALPA RVALDEDDDD VGQPSDDEDE EDYEPTDEDS DWHPGKDDEE 
       490    
QEDVDELLKE AKSSLHLKH

Isoforms

- Isoform 2 of Aprataxin and PNK-like factor - Isoform 3 of Aprataxin and PNK-like factor

Sequence View

        10         20         30         40         50         60 
MPSDFFLQPL DGGPRVPVGP GQTVIGRGPL LGITDKRVSR RHAILEVVDS QLRIKPIHRN 
        70         80         90        100        110        120 
PCFYQSSEKS QHSPMETQVW SQLHPGDSFS LLLDKYAFRV FSAESEVEME CTLRNSQMLD 
       130        140        150        160        170        180 
EDDILSEMQK SPVVNLPDKT TGASQLQGSP EITKTKCPTI DPMSSSGECR AFSEHQPRPT 
       190        200        210        220        230        240 
QRKRILPAWM LAESLSDQSL STPAEGGDKD VIQRSGKAGT CEDRTPGNTS WHGKKRLSPS 
       250        260        270        280        290        300 
GNSKSVSAEQ DPGKKCRKAD QEGPGVSSEN VPESSSSNIV KDPDVDIVKT NKQKDGILIE 
       310        320        330        340        350        360 
ELGEVSKHKA ATKPTTNEEG ESCARVQSKS PPEKSQGCHP ESSSAPSSPD ALHTDTADPV 
       370        380        390        400        410        420 
LGCSEESKVR RTACMYGANC YRRNPLHFQH FSHPGDSDYG EVHGTDEGVI GDRPECPYGA 
       430        440        450        460        470        480 
SCYRKNPQHK MEYRHSALPA RVALDEDDDD VGQPSDDEDE EDYEPTDEDS DWHPGKDDEE 
       490    
QEDVDELLKE AKSSLHLKH         10         20         30         40         50         60 
MPSDFFLQPL DGGPRVPVGP GQTVIGRGPL LGITDKRVSR RHAILEVVDS QLRIKPIHRN 
        70         80         90        100        110        120 
PCFYQSSEKS QHSPMETQVW SQLHPGDSFS LLLDKYAFRV FSAESEVEME CTLRNSQMLD 
       130        140        150        160        170        180 
EDDILSEMQK SPVVNLPDKT TGASQLQGSP EITKTKCPTI DPMSSSGECR AFSEHQPRPT 
       190        200        210        220        230        240 
QRKRILPAWM LAESLSDQSL STPAEGGDKD VIQRSGKAGT CEDRTPGNTS WHGKKRLSPS 
       250        260        270        280        290        300 
GNSKSVSAEQ DPGKKCRKAD QEGPGVSSEN VPESSSSNIV KDPDVDIVKT NKQKDGILIE 
       310        320        330        340        350        360 
ELGEVSKHKA ATKPTTNEEG ESCARVQSKS PPEKSQGCHP ESSSAPSSPD ALHTDTADPV 
       370        380        390        400        410        420 
LGCSEESKVR RTACMYGANC YRRNPLHFQH FSHPGDSDYG EVHGTDEGVI GDRPECPYGA 
       430        440        450        460        470        480 
SCYRKNPQHK MEYRHSALPA RVALDEDDDD VGQPSDDEDE EDYEPTDEDS DWHPGKDDEE 
       490    
QEDVDELLKE AKSSLHLKH



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Protease Assignment Confidence:


Evidence Names:


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Protein Neighborhood

Domains & Features

2 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini
    Name Sequence Position Modification Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMID)
    Q9D842-1-unknown MPSDFF... 1 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot
    Q9D842-109-unknown MECTLR... 109 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt67231
    Q9D842-109-unknown MECTLR... 109 inferred from isoform by sequence similarity unknown TopFIND inferred from TNt104748

C-termini

    Name Sequence Position Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)
    ...LHLKH 499 inferred from electronic annotation electronic annotation UniProtKB inferred from uniprot

Cleavages

    Protease Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)