Q9ESD7: Dysferlin
| Protein names | - Dysferlin - Dystrophy-associated fer-1-like protein - Fer-1-like protein 1 |
|---|---|
| Gene names | Dysf |
| Organism | Mus musculus |
| Protease Family | |
| Protease ID | |
| Chromosome location | |
| UniProt ID | Q9ESD7 |
1
N-termini
1
C-termini
0
Cleavages
0
Substrates
Sequence
10 20 30 40 50 60
MLRVFILFAE NVHTPDSDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD
70 80 90 100 110 120
QSSELLVVVK DHETMGRNRF LGEAKIPLQE VLATPSLSAS FNAPLLDAKQ QPTGASLVLQ
130 140 150 160 170 180
VSYTPPPGAV PLFPPPASLA PSPTLPDMDL VPDTGGEEDT EDQGLTGDEA EPFLDQSAAV
190 200 210 220 230 240
GPGGPTTPRK PPSHPPPHYP GAKRKRSSAP PRKLLSDKPQ DFQIRVQVIE GRQLPGVNIK
250 260 270 280 290 300
PVVKVTAAGQ TKRTRIQKGN SPLFNETLFF NVFDSPLELF DEPIFITVVD SRSLRTDALL
310 320 330 340 350 360
GEFRMDVGTV YREPRHAYLR KWLLLSDPDD FSAGARGYLK ASLCVLGPGD EAPLDKKDPS
370 380 390 400 410 420
EDKEDIEGNL LRPTGVALRG AHFCLKLFRA EDLPQMDDAV MDNVKQIFGF DSNKKNLVDP
430 440 450 460 470 480
FVEVSFAGKM LCSKILEKTA NPQWNQNITL PAMFPSMCEK MRIRVMDWDR LTHNDTVATT
490 500 510 520 530 540
YLGMSKISAT GGEIEEEPAG VLKSPQATDL DDNLGFLPTF GPCYVNLYGS PREFTGFPDP
550 560 570 580 590 600
YAELNTGKGE GVAYRGRVLL SLETKLVEHS EQKVEDLPAD DILRVEKYLR RRKYSLFAAF
610 620 630 640 650 660
YSATMLQDVD DAIQFEVSIG NYGNKFDTTC LPLASTTQYS RAVFDGGSLP LPVGCHYYYL
670 680 690 700 710 720
PWGNVKPVVV LSSYWEDISH RIEIQNQLLR VADRLEANLE QVHLALKAQC SSEDVDALVA
730 740 750 760 770 780
QLTDELLADC SQPLCDIHEI PSATHLDQYL LRLRTRHLSQ IKEAALALKL GHSELSTALE
790 800 810 820 830 840
QAEDWLLHLR ALAEEPQNSL PDIIIWMLQG DKRVAYQRVP AHEVLFSRRG PSYCGRNCGK
850 860 870 880 890 900
LQTIFLKYPM EGMPGARMPV QIRIKLWFGL SVDEKEFNQF AEGKLSVFAE TYENQTKLAL
910 920 930 940 950 960
VGNWGTTGLT YPKFSDVTGK IKLPKDSFRP SAGWAWAGDW FVCPEKTLLH DADAGHLSFV
970 980 990 1000 1010 1020
EEVFENQTRL PGGQWIYMSD NYTDVNGEKV LPKDDIECPL GWKWEDEEWS TDLNRAVDEQ
1030 1040 1050 1060 1070 1080
GWEYSITIPP DRKPKHWVPV EKMYYTHRRR RWVRLRRRDL SQMEALKRHR QAEAEGEGWE
1090 1100 1110 1120 1130 1140
YASLFGWKFH LEYRKTDAFR RRRWRRRMEP LEKTGPAAVF ALEGALGGMV DDKSEDSMSV
1150 1160 1170 1180 1190 1200
STLSFGVNRP TISCIFDYGN RYHLRCYLYQ ARDLPAMDKD SFSDPYAIVS FLHQSQKTVV
1210 1220 1230 1240 1250 1260
EKNTLNPTWD QTLIFYEIEI FGEPASIAEH PPCIVVELYD HDTYGADEFM GRCICQPSLE
1270 1280 1290 1300 1310 1320
RMPRLAWFPL TRGSQPAGEL LAAFELIQRE KPAIHHIPGF EMHETSRILD ETEDTDLPYP
1330 1340 1350 1360 1370 1380
PPQREANIYM VPQNIKPALQ RTAIEILAWG LRNMKSYQMA SISSPSLVVE CGGQTVQSCV
1390 1400 1410 1420 1430 1440
IRNLRKNPNF DVCTLFMEVM LPREDLYCPP IVVKVIDNRQ FGRRPVVGQC TIRSLENFLC
1450 1460 1470 1480 1490 1500
DPYSAESPSP QGGPDDVSLL SPGEDVLIDI DDKEPLIPVQ EEEFIDWWSK FFASVGEREK
1510 1520 1530 1540 1550 1560
CGSYLEKDFD TLKVYDTQLE NVEAFGGLSD FCNTFKLYRG RTQEETDDPS VIGEFKGLFK
1570 1580 1590 1600 1610 1620
IYPLPEDPAI PMPPRQFHQL AAQGPQECLV RIYIVRAFGL QPKDPNGKCD PYIKISIGKK
1630 1640 1650 1660 1670 1680
SVSDQDNYIP CTLEPVFGKM FELTCTLPLE KDLKITLYDY DLLSKDEKIG ETVIDLENRL
1690 1700 1710 1720 1730 1740
LSKFGARCGL PQTYCVSGPN QWRDQLRPSQ LLHLFCQQHR IKAPVYRTDR VTFQDKDYTI
1750 1760 1770 1780 1790 1800
EEIEAGRLPN PHLGPVEERL ALHVLQQQGL VPEHVESRPL YSPLQPDIEQ GKLQMWIDIF
1810 1820 1830 1840 1850 1860
PKVLGRPGPP FNITPRKARR FFLRCIIWNT KDVILDDLSL TGEKMSDIYV KGWMVGFEEH
1870 1880 1890 1900 1910 1920
KQKTDVHYRS LGGEGNFNWR FVFPFDYLPA EQVCAVAKKD AFWRLDKTES KIPARVVFQI
1930 1940 1950 1960 1970 1980
WDNDKFSFDD FLGSLQLDLN RMPKPAKTAE KCSLDQLDDT FHPEWFVSLF EQKTVKGWWP
1990 2000 2010 2020 2030 2040
CVTEEGEKKM LAGKLEMTLE IVAESEHEER PAGQGRDEPN MNPKLEDPRR PDTSFLWFTS
2050 2060 2070 2080 2090
PYKTMKFILW RRFRCAIILF IILFILLLFL GVFVYAFPNY AAMKLVKPFR
Isoforms
- Isoform 2 of Dysferlin - Isoform 3 of DysferlinSequence View
10 20 30 40 50 60
MLRVFILFAE NVHTPDSDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD
70 80 90 100 110 120
QSSELLVVVK DHETMGRNRF LGEAKIPLQE VLATPSLSAS FNAPLLDAKQ QPTGASLVLQ
130 140 150 160 170 180
VSYTPPPGAV PLFPPPASLA PSPTLPDMDL VPDTGGEEDT EDQGLTGDEA EPFLDQSAAV
190 200 210 220 230 240
GPGGPTTPRK PPSHPPPHYP GAKRKRSSAP PRKLLSDKPQ DFQIRVQVIE GRQLPGVNIK
250 260 270 280 290 300
PVVKVTAAGQ TKRTRIQKGN SPLFNETLFF NVFDSPLELF DEPIFITVVD SRSLRTDALL
310 320 330 340 350 360
GEFRMDVGTV YREPRHAYLR KWLLLSDPDD FSAGARGYLK ASLCVLGPGD EAPLDKKDPS
370 380 390 400 410 420
EDKEDIEGNL LRPTGVALRG AHFCLKLFRA EDLPQMDDAV MDNVKQIFGF DSNKKNLVDP
430 440 450 460 470 480
FVEVSFAGKM LCSKILEKTA NPQWNQNITL PAMFPSMCEK MRIRVMDWDR LTHNDTVATT
490 500 510 520 530 540
YLGMSKISAT GGEIEEEPAG VLKSPQATDL DDNLGFLPTF GPCYVNLYGS PREFTGFPDP
550 560 570 580 590 600
YAELNTGKGE GVAYRGRVLL SLETKLVEHS EQKVEDLPAD DILRVEKYLR RRKYSLFAAF
610 620 630 640 650 660
YSATMLQDVD DAIQFEVSIG NYGNKFDTTC LPLASTTQYS RAVFDGGSLP LPVGCHYYYL
670 680 690 700 710 720
PWGNVKPVVV LSSYWEDISH RIEIQNQLLR VADRLEANLE QVHLALKAQC SSEDVDALVA
730 740 750 760 770 780
QLTDELLADC SQPLCDIHEI PSATHLDQYL LRLRTRHLSQ IKEAALALKL GHSELSTALE
790 800 810 820 830 840
QAEDWLLHLR ALAEEPQNSL PDIIIWMLQG DKRVAYQRVP AHEVLFSRRG PSYCGRNCGK
850 860 870 880 890 900
LQTIFLKYPM EGMPGARMPV QIRIKLWFGL SVDEKEFNQF AEGKLSVFAE TYENQTKLAL
910 920 930 940 950 960
VGNWGTTGLT YPKFSDVTGK IKLPKDSFRP SAGWAWAGDW FVCPEKTLLH DADAGHLSFV
970 980 990 1000 1010 1020
EEVFENQTRL PGGQWIYMSD NYTDVNGEKV LPKDDIECPL GWKWEDEEWS TDLNRAVDEQ
1030 1040 1050 1060 1070 1080
GWEYSITIPP DRKPKHWVPV EKMYYTHRRR RWVRLRRRDL SQMEALKRHR QAEAEGEGWE
1090 1100 1110 1120 1130 1140
YASLFGWKFH LEYRKTDAFR RRRWRRRMEP LEKTGPAAVF ALEGALGGMV DDKSEDSMSV
1150 1160 1170 1180 1190 1200
STLSFGVNRP TISCIFDYGN RYHLRCYLYQ ARDLPAMDKD SFSDPYAIVS FLHQSQKTVV
1210 1220 1230 1240 1250 1260
EKNTLNPTWD QTLIFYEIEI FGEPASIAEH PPCIVVELYD HDTYGADEFM GRCICQPSLE
1270 1280 1290 1300 1310 1320
RMPRLAWFPL TRGSQPAGEL LAAFELIQRE KPAIHHIPGF EMHETSRILD ETEDTDLPYP
1330 1340 1350 1360 1370 1380
PPQREANIYM VPQNIKPALQ RTAIEILAWG LRNMKSYQMA SISSPSLVVE CGGQTVQSCV
1390 1400 1410 1420 1430 1440
IRNLRKNPNF DVCTLFMEVM LPREDLYCPP IVVKVIDNRQ FGRRPVVGQC TIRSLENFLC
1450 1460 1470 1480 1490 1500
DPYSAESPSP QGGPDDVSLL SPGEDVLIDI DDKEPLIPVQ EEEFIDWWSK FFASVGEREK
1510 1520 1530 1540 1550 1560
CGSYLEKDFD TLKVYDTQLE NVEAFGGLSD FCNTFKLYRG RTQEETDDPS VIGEFKGLFK
1570 1580 1590 1600 1610 1620
IYPLPEDPAI PMPPRQFHQL AAQGPQECLV RIYIVRAFGL QPKDPNGKCD PYIKISIGKK
1630 1640 1650 1660 1670 1680
SVSDQDNYIP CTLEPVFGKM FELTCTLPLE KDLKITLYDY DLLSKDEKIG ETVIDLENRL
1690 1700 1710 1720 1730 1740
LSKFGARCGL PQTYCVSGPN QWRDQLRPSQ LLHLFCQQHR IKAPVYRTDR VTFQDKDYTI
1750 1760 1770 1780 1790 1800
EEIEAGRLPN PHLGPVEERL ALHVLQQQGL VPEHVESRPL YSPLQPDIEQ GKLQMWIDIF
1810 1820 1830 1840 1850 1860
PKVLGRPGPP FNITPRKARR FFLRCIIWNT KDVILDDLSL TGEKMSDIYV KGWMVGFEEH
1870 1880 1890 1900 1910 1920
KQKTDVHYRS LGGEGNFNWR FVFPFDYLPA EQVCAVAKKD AFWRLDKTES KIPARVVFQI
1930 1940 1950 1960 1970 1980
WDNDKFSFDD FLGSLQLDLN RMPKPAKTAE KCSLDQLDDT FHPEWFVSLF EQKTVKGWWP
1990 2000 2010 2020 2030 2040
CVTEEGEKKM LAGKLEMTLE IVAESEHEER PAGQGRDEPN MNPKLEDPRR PDTSFLWFTS
2050 2060 2070 2080 2090
PYKTMKFILW RRFRCAIILF IILFILLLFL GVFVYAFPNY AAMKLVKPFR
10 20 30 40 50 60
MLRVFILFAE NVHTPDSDIS DAYCSAVFAG VKKRTKVIKN SVNPVWNEGF EWDLKGIPLD
70 80 90 100 110 120
QSSELLVVVK DHETMGRNRF LGEAKIPLQE VLATPSLSAS FNAPLLDAKQ QPTGASLVLQ
130 140 150 160 170 180
VSYTPPPGAV PLFPPPASLA PSPTLPDMDL VPDTGGEEDT EDQGLTGDEA EPFLDQSAAV
190 200 210 220 230 240
GPGGPTTPRK PPSHPPPHYP GAKRKRSSAP PRKLLSDKPQ DFQIRVQVIE GRQLPGVNIK
250 260 270 280 290 300
PVVKVTAAGQ TKRTRIQKGN SPLFNETLFF NVFDSPLELF DEPIFITVVD SRSLRTDALL
310 320 330 340 350 360
GEFRMDVGTV YREPRHAYLR KWLLLSDPDD FSAGARGYLK ASLCVLGPGD EAPLDKKDPS
370 380 390 400 410 420
EDKEDIEGNL LRPTGVALRG AHFCLKLFRA EDLPQMDDAV MDNVKQIFGF DSNKKNLVDP
430 440 450 460 470 480
FVEVSFAGKM LCSKILEKTA NPQWNQNITL PAMFPSMCEK MRIRVMDWDR LTHNDTVATT
490 500 510 520 530 540
YLGMSKISAT GGEIEEEPAG VLKSPQATDL DDNLGFLPTF GPCYVNLYGS PREFTGFPDP
550 560 570 580 590 600
YAELNTGKGE GVAYRGRVLL SLETKLVEHS EQKVEDLPAD DILRVEKYLR RRKYSLFAAF
610 620 630 640 650 660
YSATMLQDVD DAIQFEVSIG NYGNKFDTTC LPLASTTQYS RAVFDGGSLP LPVGCHYYYL
670 680 690 700 710 720
PWGNVKPVVV LSSYWEDISH RIEIQNQLLR VADRLEANLE QVHLALKAQC SSEDVDALVA
730 740 750 760 770 780
QLTDELLADC SQPLCDIHEI PSATHLDQYL LRLRTRHLSQ IKEAALALKL GHSELSTALE
790 800 810 820 830 840
QAEDWLLHLR ALAEEPQNSL PDIIIWMLQG DKRVAYQRVP AHEVLFSRRG PSYCGRNCGK
850 860 870 880 890 900
LQTIFLKYPM EGMPGARMPV QIRIKLWFGL SVDEKEFNQF AEGKLSVFAE TYENQTKLAL
910 920 930 940 950 960
VGNWGTTGLT YPKFSDVTGK IKLPKDSFRP SAGWAWAGDW FVCPEKTLLH DADAGHLSFV
970 980 990 1000 1010 1020
EEVFENQTRL PGGQWIYMSD NYTDVNGEKV LPKDDIECPL GWKWEDEEWS TDLNRAVDEQ
1030 1040 1050 1060 1070 1080
GWEYSITIPP DRKPKHWVPV EKMYYTHRRR RWVRLRRRDL SQMEALKRHR QAEAEGEGWE
1090 1100 1110 1120 1130 1140
YASLFGWKFH LEYRKTDAFR RRRWRRRMEP LEKTGPAAVF ALEGALGGMV DDKSEDSMSV
1150 1160 1170 1180 1190 1200
STLSFGVNRP TISCIFDYGN RYHLRCYLYQ ARDLPAMDKD SFSDPYAIVS FLHQSQKTVV
1210 1220 1230 1240 1250 1260
EKNTLNPTWD QTLIFYEIEI FGEPASIAEH PPCIVVELYD HDTYGADEFM GRCICQPSLE
1270 1280 1290 1300 1310 1320
RMPRLAWFPL TRGSQPAGEL LAAFELIQRE KPAIHHIPGF EMHETSRILD ETEDTDLPYP
1330 1340 1350 1360 1370 1380
PPQREANIYM VPQNIKPALQ RTAIEILAWG LRNMKSYQMA SISSPSLVVE CGGQTVQSCV
1390 1400 1410 1420 1430 1440
IRNLRKNPNF DVCTLFMEVM LPREDLYCPP IVVKVIDNRQ FGRRPVVGQC TIRSLENFLC
1450 1460 1470 1480 1490 1500
DPYSAESPSP QGGPDDVSLL SPGEDVLIDI DDKEPLIPVQ EEEFIDWWSK FFASVGEREK
1510 1520 1530 1540 1550 1560
CGSYLEKDFD TLKVYDTQLE NVEAFGGLSD FCNTFKLYRG RTQEETDDPS VIGEFKGLFK
1570 1580 1590 1600 1610 1620
IYPLPEDPAI PMPPRQFHQL AAQGPQECLV RIYIVRAFGL QPKDPNGKCD PYIKISIGKK
1630 1640 1650 1660 1670 1680
SVSDQDNYIP CTLEPVFGKM FELTCTLPLE KDLKITLYDY DLLSKDEKIG ETVIDLENRL
1690 1700 1710 1720 1730 1740
LSKFGARCGL PQTYCVSGPN QWRDQLRPSQ LLHLFCQQHR IKAPVYRTDR VTFQDKDYTI
1750 1760 1770 1780 1790 1800
EEIEAGRLPN PHLGPVEERL ALHVLQQQGL VPEHVESRPL YSPLQPDIEQ GKLQMWIDIF
1810 1820 1830 1840 1850 1860
PKVLGRPGPP FNITPRKARR FFLRCIIWNT KDVILDDLSL TGEKMSDIYV KGWMVGFEEH
1870 1880 1890 1900 1910 1920
KQKTDVHYRS LGGEGNFNWR FVFPFDYLPA EQVCAVAKKD AFWRLDKTES KIPARVVFQI
1930 1940 1950 1960 1970 1980
WDNDKFSFDD FLGSLQLDLN RMPKPAKTAE KCSLDQLDDT FHPEWFVSLF EQKTVKGWWP
1990 2000 2010 2020 2030 2040
CVTEEGEKKM LAGKLEMTLE IVAESEHEER PAGQGRDEPN MNPKLEDPRR PDTSFLWFTS
2050 2060 2070 2080 2090
PYKTMKFILW RRFRCAIILF IILFILLLFL GVFVYAFPNY AAMKLVKPFR
Protein Neighborhood
Domains & Features
1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates
N-termini
| Name | Sequence | Position | Modification | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMID) |
|---|---|---|---|---|---|---|---|---|---|
| Q9ESD7-1-unknown | MLRVFI... | 1 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot |
C-termini
| Name | Sequence | Position | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|---|---|---|---|---|---|---|---|
| ...VKPFR | 2090 | inferred from electronic annotation | electronic annotation | UniProtKB | inferred from uniprot | |||
| ...VKPFR | 2090 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69084 | |||
| ...VKPFR | 2090 | inferred from isoform by sequence similarity | unknown | TopFIND | inferred from TCt69083 |
Cleavages
| Protease | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|
Substrates
| Substrate | Position | Sequence | Evidence type | Method | Source (database) | Source (Lab) | Evidence name | Publications (PMIDs) |
|---|