Q9ESZ8: General transcription factor II-I

General Information

Protein names	- General transcription factor II-I - GTFII-I - TFII-I - Bruton tyrosine kinase-associated protein 135 - BAP-135 - BTK-associated protein 135
Gene names	Gtf2i
Organism	Mus musculus
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9ESZ8

4 N-termini

2 C-termini

1 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of General transcription factor II-I - Isoform 3 of General transcription factor II-I - Isoform 4 of General transcription factor II-I - Isoform 5 of General transcription factor II-I - Isoform 6 of General transcription factor II-I

Sequence View

        10         20         30         40         50         60
MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
        70         80         90        100        110        120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF
       130        140        150        160        170        180
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI
       190        200        210        220        230        240
SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK
       250        260        270        280        290        300
EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS
       310        320        330        340        350        360
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN FEKWNARITD
       370        380        390        400        410        420
LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE
       430        440        450        460        470        480
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE
       490        500        510        520        530        540
ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR
       550        560        570        580        590        600
PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF
       610        620        630        640        650        660
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV SYLPPGMASK
       670        680        690        700        710        720
INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA VRTPTQTNGS NVPFKPRGRE
       730        740        750        760        770        780
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF
       790        800        810        820        830        840
RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG
       850        860        870        880        890        900
VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
       910        920        930        940        950        960
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE
       970        980        990
GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW         10         20         30         40         50         60
MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
        70         80         90        100        110        120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF
       130        140        150        160        170        180
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI
       190        200        210        220        230        240
SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK
       250        260        270        280        290        300
EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS
       310        320        330        340        350        360
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN FEKWNARITD
       370        380        390        400        410        420
LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE
       430        440        450        460        470        480
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE
       490        500        510        520        530        540
ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR
       550        560        570        580        590        600
PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF
       610        620        630        640        650        660
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV SYLPPGMASK
       670        680        690        700        710        720
INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA VRTPTQTNGS NVPFKPRGRE
       730        740        750        760        770        780
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF
       790        800        810        820        830        840
RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG
       850        860        870        880        890        900
VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
       910        920        930        940        950        960
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE
       970        980        990
GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW         10         20         30         40         50         60
MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
        70         80         90        100        110        120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF
       130        140        150        160        170        180
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI
       190        200        210        220        230        240
SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK
       250        260        270        280        290        300
EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS
       310        320        330        340        350        360
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN FEKWNARITD
       370        380        390        400        410        420
LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE
       430        440        450        460        470        480
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE
       490        500        510        520        530        540
ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR
       550        560        570        580        590        600
PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF
       610        620        630        640        650        660
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV SYLPPGMASK
       670        680        690        700        710        720
INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA VRTPTQTNGS NVPFKPRGRE
       730        740        750        760        770        780
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF
       790        800        810        820        830        840
RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG
       850        860        870        880        890        900
VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
       910        920        930        940        950        960
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE
       970        980        990
GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW         10         20         30         40         50         60
MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
        70         80         90        100        110        120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF
       130        140        150        160        170        180
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI
       190        200        210        220        230        240
SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK
       250        260        270        280        290        300
EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS
       310        320        330        340        350        360
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN FEKWNARITD
       370        380        390        400        410        420
LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE
       430        440        450        460        470        480
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE
       490        500        510        520        530        540
ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR
       550        560        570        580        590        600
PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF
       610        620        630        640        650        660
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV SYLPPGMASK
       670        680        690        700        710        720
INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA VRTPTQTNGS NVPFKPRGRE
       730        740        750        760        770        780
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF
       790        800        810        820        830        840
RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG
       850        860        870        880        890        900
VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
       910        920        930        940        950        960
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE
       970        980        990
GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW         10         20         30         40         50         60
MAQVVMSALP AEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE
        70         80         90        100        110        120
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF
       130        140        150        160        170        180
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPEHYDLATL KWILENKAGI
       190        200        210        220        230        240
SFIIKRPFLE PKKHLGGRVL AAEAERSMLS PSGSCGPIKV KTEPTEDSGI SLEMAAVTVK
       250        260        270        280        290        300
EESEDPDYYQ YNIQGPSETD GVDEKLPLSK ALQGSHHSSE GNEGTEVEVP AEDSTQHVPS
       310        320        330        340        350        360
ETSEDPEVEV TIEDDDYSPP TKRLKSTEPP PPPPVPEPAN AGKRKVREFN FEKWNARITD
       370        380        390        400        410        420
LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE
       430        440        450        460        470        480
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE
       490        500        510        520        530        540
ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR
       550        560        570        580        590        600
PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF
       610        620        630        640        650        660
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVV SYLPPGMASK
       670        680        690        700        710        720
INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNSSPQTSA VRTPTQTNGS NVPFKPRGRE
       730        740        750        760        770        780
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF
       790        800        810        820        830        840
RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG
       850        860        870        880        890        900
VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN
       910        920        930        940        950        960
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQNESE
       970        980        990
GPVIQESAEA SQLEVPVTEE IKETDGSSQI KQEPDPTW

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

4 N-termini - 2 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Evidence name
Q9ESZ8-1-unknown	MAQVVM...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76633
Q9ESZ8-1-unknown	MAQVVM...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76634
Q9ESZ8-1-unknown	MAQVVM...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76635
Q9ESZ8-1-unknown	MAQVVM...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76636
Q9ESZ8-1-unknown	MAQVVM...	1		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt76637
Q9ESZ8-2-unknown	MAQVVM...	1		inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9ESZ8-2-unknown	MAQVVM...	1		inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ESZ8-2-Acetylation	AQVVMS...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9ESZ8-2-Acetylation	AQVVMS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111347
Q9ESZ8-2-Acetylation	AQVVMS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111348
Q9ESZ8-2-Acetylation	AQVVMS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111349
Q9ESZ8-2-Acetylation	AQVVMS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111350
Q9ESZ8-2-Acetylation	AQVVMS...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt111351
Q9ESZ8-2-Acetylation	AQVVMS...	2	acetylation-	inferred from similarity	unknown	UniProtKB	inferred from uniprot (by similarity)
Q9ESZ8-686-unknown	VTVEGP...	686		inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31161
Q9ESZ8-686-unknown	VTVEGP...	686		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt154988
Q9ESZ8-686-unknown	VTVEGP...	686		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155252
Q9ESZ8-686-unknown	VTVEGP...	686		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155286
Q9ESZ8-686-unknown	VTVEGP...	686		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155475
Q9ESZ8-686-unknown	VTVEGP...	686		inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt155492

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...VPEIEV	685	inferred from cleavage	unknown	TopFIND	Inferred from cleavage TC31161
...VPEIEV	685	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138415
...VPEIEV	685	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138684
...VPEIEV	685	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138719
...VPEIEV	685	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138911
...VPEIEV	685	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt138930
...PDPTW	998	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...PDPTW	998	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72254
...PDPTW	998	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72253
...PDPTW	998	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72252
...PDPTW	998	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72255
...PDPTW	998	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt72251

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CATE_MOUSE	685	EIEV.\|.VTVE	inferred from experiment	unknown	MEROPS		Merops CATE_MOUSE -> GTF2I_MOUSE @685

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)