Q9GZT9: Egl nine homolog 1

General Information

Protein names	- Egl nine homolog 1 - 1.14.11.29 {ECO:0000269\|PubMed:25129147} - Hypoxia-inducible factor prolyl hydroxylase 2 - HIF-PH2 - HIF-prolyl hydroxylase 2 - HPH-2 - Prolyl hydroxylase domain-containing protein 2 - PHD2 - SM-20
Gene names	EGLN1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9GZT9

3 N-termini

2 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Egl nine homolog 1 - Isoform 3 of Egl nine homolog 1

Sequence View

        10         20         30         40         50         60
MANDSGGPGG PSPSERDRQY CELCGKMENL LRCSRCRSSF YCCKEHQRQD WKKHKLVCQG
        70         80         90        100        110        120
SEGALGHGVG PHQHSGPAPP AAVPPPRAGA REPRKAAARR DNASGDAAKG KVKAKPPADP
       130        140        150        160        170        180
AAAASPCRAA AGGQGSAVAA EAEPGKEEPP ARSSLFQEKA NLYPPSNTPG DALSPGGGLR
       190        200        210        220        230        240
PNGQTKPLPA LKLALEYIVP CMNKHGICVV DDFLGKETGQ QIGDEVRALH DTGKFTDGQL
       250        260        270        280        290        300
VSQKSDSSKD IRGDKITWIE GKEPGCETIG LLMSSMDDLI RHCNGKLGSY KINGRTKAMV
       310        320        330        340        350        360
ACYPGNGTGY VRHVDNPNGD GRCVTCIYYL NKDWDAKVSG GILRIFPEGK AQFADIEPKF
       370        380        390        400        410        420
DRLLFFWSDR RNPHEVQPAY ATRYAITVWY FDADERARAK VKYLTGEKGV RVELNKPSDS

VGKDVF         10         20         30         40         50         60
MANDSGGPGG PSPSERDRQY CELCGKMENL LRCSRCRSSF YCCKEHQRQD WKKHKLVCQG
        70         80         90        100        110        120
SEGALGHGVG PHQHSGPAPP AAVPPPRAGA REPRKAAARR DNASGDAAKG KVKAKPPADP
       130        140        150        160        170        180
AAAASPCRAA AGGQGSAVAA EAEPGKEEPP ARSSLFQEKA NLYPPSNTPG DALSPGGGLR
       190        200        210        220        230        240
PNGQTKPLPA LKLALEYIVP CMNKHGICVV DDFLGKETGQ QIGDEVRALH DTGKFTDGQL
       250        260        270        280        290        300
VSQKSDSSKD IRGDKITWIE GKEPGCETIG LLMSSMDDLI RHCNGKLGSY KINGRTKAMV
       310        320        330        340        350        360
ACYPGNGTGY VRHVDNPNGD GRCVTCIYYL NKDWDAKVSG GILRIFPEGK AQFADIEPKF
       370        380        390        400        410        420
DRLLFFWSDR RNPHEVQPAY ATRYAITVWY FDADERARAK VKYLTGEKGV RVELNKPSDS

VGKDVF

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 2 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9GZT9-1-unknown	MANDSG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73728
Q9GZT9-1-unknown	MANDSG...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt73729
Q9GZT9-2-unknown	MANDSG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9GZT9-2-Acetylation	ANDSGG...	2	acetylation-	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9GZT9-2-Acetylation	ANDSGG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9GZT9-2-Acetylation	ANDSGG...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9GZT9-2-Acetylation	ANDSGG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110947
Q9GZT9-2-Acetylation	ANDSGG...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt110948

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...GKDVF	426	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...GKDVF	426	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt69347
...GKDVF	426	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TCt69346
...GKDVF	426		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...GKDVF	426		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)