Q9H0H0: Integrator complex subunit 2

General Information

Protein names	- Integrator complex subunit 2 - Int2
Gene names	INTS2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H0H0

2 N-termini

3 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MKDQQTVIMT ECTSLQFVSP FAFEAMQKVD VVCLASLSDP ELRLLLPCLV RMALCAPADQ
        70         80         90        100        110        120
SQSWAQDKKL ILRLLSGVEA VNSIVALLSV DFHALEQDAS KEQQLRHKLG GGSGESILVS
       130        140        150        160        170        180
QLQHGLTLEF EHSDSPRRLR LVLSELLAIM NKVSESNGEF FFKSSELFES PVYLEEAADV
       190        200        210        220        230        240
LCILQAELPS LLPIVDVAEA LLHVRNGAWF LCLLVANVPD SFNEVCRGLI KNGERQDEES
       250        260        270        280        290        300
LGGRRRTDAL RFLCKMNPSQ ALKVRGMVVE ECHLPGLGVA LTLDHTKNEA CEDGVSDLVC
       310        320        330        340        350        360
FVSGLLLGTN AKVRTWFGTF IRNGQQRKRE TSSSVLWQMR RQLLLELMGI LPTVRSTRIV
       370        380        390        400        410        420
EEADVDMEPN VSVYSGLKEE HVVKASALLR LYCALMGIAG LKPTEEEAEQ LLQLMTSRPP
       430        440        450        460        470        480
ATPAGVRFVS LSFCMLLAFS TLVSTPEQEQ LMVVWLSWMI KEEAYFESTS GVSASFGEML
       490        500        510        520        530        540
LLVAMYFHSN QLSAIIDLVC STLGMKIVIK PSSLSRMKTI FTQEIFTEQV VTAHAVRVPV
       550        560        570        580        590        600
TSNLSANITG FLPIHCIYQL LRSRSFTKHK VSIKDWIYRQ LCETSTPLHP QLLPLIDVYI
       610        620        630        640        650        660
NSILTPASKS NPEATNQPVT EQEILNIFQG VIGGDNIRLN QRFSITAQLL VLYYILSYEE
       670        680        690        700        710        720
ALLANTKTLA AMQRKPKSYS SSLMDQIPIK FLIRQAQGLQ QELGGLHSAL LRLLATNYPH
       730        740        750        760        770        780
LCIVDDWICE EEITGTDALL RRMLLTNNAK NHSPKQLQEA FSAVPVNNTQ VMQIIEHLTL
       790        800        810        820        830        840
LSASELIPYA EVLTSNMSQL LNSGVPRRIL QTVNKLWMVL NTVMPRRLWV MTVNALQPSI
       850        860        870        880        890        900
KFVRQQKYTQ NDLMIDPLIV LRCDQRVHRC PPLMDITLHM LNGYLLASKA YLSAHLKETE
       910        920        930        940        950        960
QDRPSQNNTI GLVGQTDAPE VTREELKNAL LAAQDSAAVQ ILLEICLPTE EEKANGVNPD
       970        980        990       1000       1010       1020
SLLRNVQSVI TTSAPNKGME EGEDNLLCNL REVQCLICCL LHQMYIADPN IAKLVHFQGY
      1030       1040       1050       1060       1070       1080
PCELLPLTVA GIPSMHICLD FIPELIAQPE LEKQIFAIQL LSHLCIQYAL PKSLSVARLA
      1090       1100       1110       1120       1130       1140
VNVMGTLLTV LTQAKRYAFF MPTLPSLVSF CRAFPPLYED IMSLLIQIGQ VCASDVATQT
      1150       1160       1170       1180       1190       1200
RDIDPIITRL QQIKEKPSGW SQICKDSSYK NGSRDTGSMD PDVQLCHCIE RTVIEIINMS

VSGI

Isoforms

Sequence View

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Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

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Protein Neighborhood

Domains & Features

2 N-termini - 3 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H0H0-1-unknown	MKDQQT...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H0H0-9-unknown	MTECTS...	9	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000251334
Q9H0H0-9-unknown	MTECTS...	9	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000461996

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...SIVALL	87	inferred from electronic annotation	unknown	Ensembl		inferred from ensembl protein ENSP00000461996
...SVSGI	1204	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...SVSGI	1204		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...SVSGI	1204		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)