Q9H223: EH domain-containing protein 4 {ECO:0000305}

General Information

Protein names	- EH domain-containing protein 4 {ECO:0000305} - Hepatocellular carcinoma-associated protein 10/11 {ECO:0000303\|PubMed:12097419} - PAST homolog 4 {ECO:0000305}
Gene names	EHD4
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H223

4 N-termini

3 C-termini

1 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MFSWMGRQAG GRERAGGADA VQTVTGGLRS LYLRKVLPLE EAYRFHEFHS PALEDADFEN
        70         80         90        100        110        120
KPMILLVGQY STGKTTFIRY LLEQDFPGMR IGPEPTTDSF IAVMYGETEG STPGNALVVD
       130        140        150        160        170        180
PKKPFRKLSR FGNAFLNRFM CSQLPNQVLK SISVIDSPGI LSGEKQRISR GYDFCQVLQW
       190        200        210        220        230        240
FAERVDRIIL LFDAHKLDIS DEFSEAIKAF RGQDDKIRVV LNKADQVDTQ QLMRVYGALM
       250        260        270        280        290        300
WSLGKVINTP EVLRVYIGSF WAQPLQNTDN RRLFEAEAQD LFRDIQSLPQ KAAVRKLNDL
       310        320        330        340        350        360
IKRARLAKVH AYIISYLKKE MPSVFGKENK KRELISRLPE IYIQLQREYQ ISAGDFPEVK
       370        380        390        400        410        420
AMQEQLENYD FTKFHSLKPK LIEAVDNMLS NKISPLMNLI SQEETSTPTQ LVQGGAFDGT
       430        440        450        460        470        480
TEGPFNQGYG EGAKEGADEE EWVVAKDKPV YDELFYTLSP INGKISGVNA KKEMVTSKLP
       490        500        510        520        530        540
NSVLGKIWKL ADCDCDGMLD EEEFALAKHL IKIKLDGYEL PSSLPPHLVP PSHRKSLPKA

D

Isoforms

Sequence View

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Protein Neighborhood

Domains & Features

4 N-termini - 3 C-termini - 1 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H223-1-acetylation	MFSWMG...	1	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H223-1-unknown	MFSWMG...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H223-419-	GTTEGP...	419			Subtiligase Based Positive Selection		Wells	apoptotic_MM1s_bort	23264352
Q9H223-497-unknown	GMLDEE...	497		inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1349

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
...DCDCDG	496	inferred from cleavage	unknown	TopFIND		Inferred from cleavage TC1349
...LPKAD	541	inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
...LPKAD	541		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LPKAD	541		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,
...LPKAD	541		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345,
...LPKAD	541		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345,

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)
CASP1_HUMAN	496	DCDG.\|.GMLD	inferred from experiment	unknown	MEROPS	Wells JA	Agard NJ et al.:Inflammatory stimuli regulate c... (C14.001)	20173201,

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)