Q9H2A2: 2-aminomuconic semialdehyde dehydrogenase {ECO:0000305|PubMed:29703752}

General Information

Protein names	- 2-aminomuconic semialdehyde dehydrogenase {ECO:0000305\|PubMed:29703752} - 1.2.1.32 {ECO:0000269\|PubMed:29703752} - Aldehyde dehydrogenase 12 - Aldehyde dehydrogenase family 8 member A1 {ECO:0000312\|HGNC:HGNC:15471}
Gene names	ALDH8A1
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H2A2

1 N-termini

1 C-termini

0 Cleavages

0 Substrates

Sequence

        10         20         30         40         50         60
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS
        70         80         90        100        110        120
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS
       130        140        150        160        170        180
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS
       190        200        210        220        230        240
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT
       250        260        270        280        290        300
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
       310        320        330        340        350        360
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK
       370        380        390        400        410        420
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA
       430        440        450        460        470        480
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI

KTITVKH

Isoforms

- Isoform 2 of Aldehyde dehydrogenase family 8 member A1 - Isoform 3 of Aldehyde dehydrogenase family 8 member A1 - Isoform 4 of Aldehyde dehydrogenase family 8 member A1 - Isoform 2 of 2-aminomuconic semialdehyde dehydrogenase - Isoform 3 of 2-aminomuconic semialdehyde dehydrogenase - Isoform 4 of 2-aminomuconic semialdehyde dehydrogenase

Sequence View

        10         20         30         40         50         60
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS
        70         80         90        100        110        120
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS
       130        140        150        160        170        180
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS
       190        200        210        220        230        240
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT
       250        260        270        280        290        300
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
       310        320        330        340        350        360
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK
       370        380        390        400        410        420
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA
       430        440        450        460        470        480
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI

KTITVKH         10         20         30         40         50         60
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS
        70         80         90        100        110        120
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS
       130        140        150        160        170        180
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS
       190        200        210        220        230        240
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT
       250        260        270        280        290        300
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
       310        320        330        340        350        360
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK
       370        380        390        400        410        420
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA
       430        440        450        460        470        480
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI

KTITVKH         10         20         30         40         50         60
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS
        70         80         90        100        110        120
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS
       130        140        150        160        170        180
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS
       190        200        210        220        230        240
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT
       250        260        270        280        290        300
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
       310        320        330        340        350        360
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK
       370        380        390        400        410        420
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA
       430        440        450        460        470        480
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI

KTITVKH         10         20         30         40         50         60
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS
        70         80         90        100        110        120
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS
       130        140        150        160        170        180
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS
       190        200        210        220        230        240
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT
       250        260        270        280        290        300
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
       310        320        330        340        350        360
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK
       370        380        390        400        410        420
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA
       430        440        450        460        470        480
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI

KTITVKH         10         20         30         40         50         60
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS
        70         80         90        100        110        120
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS
       130        140        150        160        170        180
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS
       190        200        210        220        230        240
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT
       250        260        270        280        290        300
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
       310        320        330        340        350        360
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK
       370        380        390        400        410        420
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA
       430        440        450        460        470        480
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI

KTITVKH         10         20         30         40         50         60
MAGTNALLML ENFIDGKFLP CSSYIDSYDP STGEVYCRVP NSGKDEIEAA VKAAREAFPS
        70         80         90        100        110        120
WSSRSPQERS RVLNQVADLL EQSLEEFAQA ESKDQGKTLA LARTMDIPRS VQNFRFFASS
       130        140        150        160        170        180
SLHHTSECTQ MDHLGCMHYT VRAPVGVAGL ISPWNLPLYL LTWKIAPAMA AGNTVIAKPS
       190        200        210        220        230        240
ELTSVTAWML CKLLDKAGVP PGVVNIVFGT GPRVGEALVS HPEVPLISFT GSQPTAERIT
       250        260        270        280        290        300
QLSAPHCKKL SLELGGKNPA IIFEDANLDE CIPATVRSSF ANQGEICLCT SRIFVQKSIY
       310        320        330        340        350        360
SEFLKRFVEA TRKWKVGIPS DPLVSIGALI SKAHLEKVRS YVKRALAEGA QIWCGEGVDK
       370        380        390        400        410        420
LSLPARNQAG YFMLPTVITD IKDESCCMTE EIFGPVTCVV PFDSEEEVIE RANNVKYGLA
       430        440        450        460        470        480
ATVWSSNVGR VHRVAKKLQS GLVWTNCWLI RELNLPFGGM KSSGIGREGA KDSYDFFTEI

KTITVKH

Name	Sequence	Position	Evidence type	Method	Source (database)	Evidence name
Q9H2A2-1-unknown	MAGTNA...	1	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
Q9H2A2-1-unknown	MAGTNA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66706
Q9H2A2-1-unknown	MAGTNA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66707
Q9H2A2-1-unknown	MAGTNA...	1	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TNt66708

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...ITVKH	487	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...ITVKH	487	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62324
...ITVKH	487	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt62326

TopFIND

Q9H2A2: 2-aminomuconic semialdehyde dehydrogenase {ECO:0000305|PubMed:29703752}

General Information

1

N-termini

1

C-termini

0

Cleavages

0

Substrates

Sequence

Isoforms

Filter Information:

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Evidence Codes:

Methodology:

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Protein Neighborhood

Domains & Features

1 N-termini - 1 C-termini - 0 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates