TopFIND 4.0

Q9H324: A disintegrin and metalloproteinase with thrombospondin motifs 10

General Information

Protein names
- A disintegrin and metalloproteinase with thrombospondin motifs 10
- ADAM-TS 10
- ADAM-TS10
- ADAMTS-10
- 3.4.24.-
Gene names ADAMTS10
Organism Homo sapiens
Protease Family
Protease ID M12.235
Chromosome location
UniProt ID Q9H324

4

N-termini

4

C-termini

3

Cleavages

0

Substrates

Sequence

        10         20         30         40         50         60 
MAPACQILRW ALALGLGLMF EVTHAFRSQD EFLSSLESYE IAFPTRVDHN GALLAFSPPP 
        70         80         90        100        110        120 
PRRQRRGTGA TAESRLFYKV ASPSTHFLLN LTRSSRLLAG HVSVEYWTRE GLAWQRAARP 
       130        140        150        160        170        180 
HCLYAGHLQG QASTSHVAIS TCGGLHGLIV ADEEEYLIEP LHGGPKGSRS PEESGPHVVY 
       190        200        210        220        230        240 
KRSSLRHPHL DTACGVRDEK PWKGRPWWLR TLKPPPARPL GNETERGQPG LKRSVSRERY 
       250        260        270        280        290        300 
VETLVVADKM MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GSTVNILVTR LILLTEDQPT 
       310        320        330        340        350        360 
LEITHHAGKS LDSFCKWQKS IVNHSGHGNA IPENGVANHD TAVLITRYDI CIYKNKPCGT 
       370        380        390        400        410        420 
LGLAPVGGMC ERERSCSVNE DIGLATAFTI AHEIGHTFGM NHDGVGNSCG ARGQDPAKLM 
       430        440        450        460        470        480 
AAHITMKTNP FVWSSCSRDY ITSFLDSGLG LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR 
       490        500        510        520        530        540 
FQHGVKSRQC KYGEVCSELW CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG 
       550        560        570        580        590        600 
SRPEGVDGAW GPWTPWGDCS RTCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTDD 
       610        620        630        640        650        660 
CPPGSQDFRE VQCSEFDSIP FRGKFYKWKT YRGGGVKACS LTCLAEGFNF YTERAAAVVD 
       670        680        690        700        710        720 
GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG DGSACETIEG VFSPASPGAG 
       730        740        750        760        770        780 
YEDVVWIPKG SVHIFIQDLN LSLSHLALKG DQESLLLEGL PGTPQPHRLP LAGTTFQLRQ 
       790        800        810        820        830        840 
GPDQVQSLEA LGPINASLIV MVLARTELPA LRYRFNAPIA RDSLPPYSWH YAPWTKCSAQ 
       850        860        870        880        890        900 
CAGGSQVQAV ECRNQLDSSA VAPHYCSAHS KLPKRQRACN TEPCPPDWVV GNWSLCSRSC 
       910        920        930        940        950        960 
DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACH GPTCPPEWAA LDWSECTPSC 
       970        980        990       1000       1010       1020 
GPGLRHRVVL CKSADHRATL PPAHCSPAAK PPATMRCNLR RCPPARWVAG EWGECSAQCG 
      1030       1040       1050       1060       1070       1080 
VGQRQRSVRC TSHTGQASHE CTEALRPPTT QQCEAKCDSP TPGDGPEECK DVNKVAYCPL 
      1090       1100    
VLKFQFCSRA YFRQMCCKTC HGH

Isoforms

- Isoform 2 of A disintegrin and metalloproteinase with thrombospondin motifs 10

Sequence View

        10         20         30         40         50         60 
MAPACQILRW ALALGLGLMF EVTHAFRSQD EFLSSLESYE IAFPTRVDHN GALLAFSPPP 
        70         80         90        100        110        120 
PRRQRRGTGA TAESRLFYKV ASPSTHFLLN LTRSSRLLAG HVSVEYWTRE GLAWQRAARP 
       130        140        150        160        170        180 
HCLYAGHLQG QASTSHVAIS TCGGLHGLIV ADEEEYLIEP LHGGPKGSRS PEESGPHVVY 
       190        200        210        220        230        240 
KRSSLRHPHL DTACGVRDEK PWKGRPWWLR TLKPPPARPL GNETERGQPG LKRSVSRERY 
       250        260        270        280        290        300 
VETLVVADKM MVAYHGRRDV EQYVLAIMNI VAKLFQDSSL GSTVNILVTR LILLTEDQPT 
       310        320        330        340        350        360 
LEITHHAGKS LDSFCKWQKS IVNHSGHGNA IPENGVANHD TAVLITRYDI CIYKNKPCGT 
       370        380        390        400        410        420 
LGLAPVGGMC ERERSCSVNE DIGLATAFTI AHEIGHTFGM NHDGVGNSCG ARGQDPAKLM 
       430        440        450        460        470        480 
AAHITMKTNP FVWSSCSRDY ITSFLDSGLG LCLNNRPPRQ DFVYPTVAPG QAYDADEQCR 
       490        500        510        520        530        540 
FQHGVKSRQC KYGEVCSELW CLSKSNRCIT NSIPAAEGTL CQTHTIDKGW CYKRVCVPFG 
       550        560        570        580        590        600 
SRPEGVDGAW GPWTPWGDCS RTCGGGVSSS SRHCDSPRPT IGGKYCLGER RRHRSCNTDD 
       610        620        630        640        650        660 
CPPGSQDFRE VQCSEFDSIP FRGKFYKWKT YRGGGVKACS LTCLAEGFNF YTERAAAVVD 
       670        680        690        700        710        720 
GTPCRPDTVD ICVSGECKHV GCDRVLGSDL REDKCRVCGG DGSACETIEG VFSPASPGAG 
       730        740        750        760        770        780 
YEDVVWIPKG SVHIFIQDLN LSLSHLALKG DQESLLLEGL PGTPQPHRLP LAGTTFQLRQ 
       790        800        810        820        830        840 
GPDQVQSLEA LGPINASLIV MVLARTELPA LRYRFNAPIA RDSLPPYSWH YAPWTKCSAQ 
       850        860        870        880        890        900 
CAGGSQVQAV ECRNQLDSSA VAPHYCSAHS KLPKRQRACN TEPCPPDWVV GNWSLCSRSC 
       910        920        930        940        950        960 
DAGVRSRSVV CQRRVSAAEE KALDDSACPQ PRPPVLEACH GPTCPPEWAA LDWSECTPSC 
       970        980        990       1000       1010       1020 
GPGLRHRVVL CKSADHRATL PPAHCSPAAK PPATMRCNLR RCPPARWVAG EWGECSAQCG 
      1030       1040       1050       1060       1070       1080 
VGQRQRSVRC TSHTGQASHE CTEALRPPTT QQCEAKCDSP TPGDGPEECK DVNKVAYCPL 
      1090       1100    
VLKFQFCSRA YFRQMCCKTC HGH



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Protein Neighborhood

Domains & Features

4 N-termini - 4 C-termini - 3 Cleavages - 0 Substrates

N-termini

C-termini

Cleavages

Substrates

    Substrate Position Sequence Evidence type Method Source (database) Source (Lab) Evidence name Publications (PMIDs)