Q9H6S3: Epidermal growth factor receptor kinase substrate 8-like protein 2

General Information

Protein names	- Epidermal growth factor receptor kinase substrate 8-like protein 2 - EPS8-like protein 2 - Epidermal growth factor receptor pathway substrate 8-related protein 2 - EPS8-related protein 2
Gene names	EPS8L2
Organism	Homo sapiens
Protease Family
Protease ID
Chromosome location
UniProt ID	Q9H6S3

3 N-termini

6 C-termini

0 Cleavages

0 Substrates

Sequence

Isoforms

- Isoform 2 of Epidermal growth factor receptor kinase substrate 8-like protein 2 - Isoform 3 of Epidermal growth factor receptor kinase substrate 8-like protein 2

Sequence View

        10         20         30         40         50         60
MSQSGAVSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS QYHVQHLATF
        70         80         90        100        110        120
IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS LRLLDIESQE ELEDFPLPTV
       130        140        150        160        170        180
QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV HFFHCDEVEA ELVHEDIESA LADCRLGKKM
       190        200        210        220        230        240
RPQTLKGHQE KIRQRQSILP PPQGPAPIPF QHRGGDSPEA KNRVGPQVPL SEPGFRRRES
       250        260        270        280        290        300
QEEPRAVLAQ KIEKETQILN CALDDIEWFV ARLQKAAEAF KQLNQRKKGK KKGKKAPAEG
       310        320        330        340        350        360
VLTLRARPPS EGEFIDCFQK IKLAINLLAK LQKHIQNPSA AELVHFLFGP LDLIVNTCSG
       370        380        390        400        410        420
PDIARSVSCP LLSRDAVDFL RGHLVPKEMS LWESLGESWM RPRSEWPREP QVPLYVPKFH
       430        440        450        460        470        480
SGWEPPVDVL QEAPWEVEGL ASAPIEEVSP VSRQSIRNSQ KHSPTSEPTP PGDALPPVSS
       490        500        510        520        530        540
PHTHRGYQPT PAMAKYVKIL YDFTARNANE LSVLKDEVLE VLEDGRQWWK LRSRSGQAGY
       550        560        570        580        590        600
VPCNILGEAR PEDAGAPFEQ AGQKYWGPAS PTHKLPPSFP GNKDELMQHM DEVNDELIRK
       610        620        630        640        650        660
ISNIRAQPQR HFRVERSQPV SQPLTYESGP DEVRAWLEAK AFSPRIVENL GILTGPQLFS
       670        680        690        700        710
LNKEELKKVC GEEGVRVYSQ LTMQKAFLEK QQSGSELEEL MNKFHSMNQR RGEDS         10         20         30         40         50         60
MSQSGAVSCC PGATNGSLGR SDGVAKMSPK DLFEQRKKYS NSNVIMHETS QYHVQHLATF
        70         80         90        100        110        120
IMDKSEAITS VDDAIRKLVQ LSSKEKIWTQ EMLLQVNDQS LRLLDIESQE ELEDFPLPTV
       130        140        150        160        170        180
QRSQTVLNQL RYPSVLLLVC QDSEQSKPDV HFFHCDEVEA ELVHEDIESA LADCRLGKKM
       190        200        210        220        230        240
RPQTLKGHQE KIRQRQSILP PPQGPAPIPF QHRGGDSPEA KNRVGPQVPL SEPGFRRRES
       250        260        270        280        290        300
QEEPRAVLAQ KIEKETQILN CALDDIEWFV ARLQKAAEAF KQLNQRKKGK KKGKKAPAEG
       310        320        330        340        350        360
VLTLRARPPS EGEFIDCFQK IKLAINLLAK LQKHIQNPSA AELVHFLFGP LDLIVNTCSG
       370        380        390        400        410        420
PDIARSVSCP LLSRDAVDFL RGHLVPKEMS LWESLGESWM RPRSEWPREP QVPLYVPKFH
       430        440        450        460        470        480
SGWEPPVDVL QEAPWEVEGL ASAPIEEVSP VSRQSIRNSQ KHSPTSEPTP PGDALPPVSS
       490        500        510        520        530        540
PHTHRGYQPT PAMAKYVKIL YDFTARNANE LSVLKDEVLE VLEDGRQWWK LRSRSGQAGY
       550        560        570        580        590        600
VPCNILGEAR PEDAGAPFEQ AGQKYWGPAS PTHKLPPSFP GNKDELMQHM DEVNDELIRK
       610        620        630        640        650        660
ISNIRAQPQR HFRVERSQPV SQPLTYESGP DEVRAWLEAK AFSPRIVENL GILTGPQLFS
       670        680        690        700        710
LNKEELKKVC GEEGVRVYSQ LTMQKAFLEK QQSGSELEEL MNKFHSMNQR RGEDS

Filter Information:

(REFRESH)

Directness:

Physiological Relevance:

Evidence Codes:

Methodology:

Perturbation of System:

Biological System:

Protease Assignment Confidence:

Evidence Names:

Database:

Lab:

Protein Neighborhood

Domains & Features

3 N-termini - 6 C-termini - 0 Cleavages - 0 Substrates

N-termini

Name	Sequence	Position	Modification	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMID)
Q9H6S3-1-unknown	MSQSGA...	1		inferred from electronic annotation	electronic annotation	UniProtKB		inferred from uniprot
Q9H6S3-1-unknown	MSQSGA...	1		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74179
Q9H6S3-2-acetylation	SQSGAV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: Complementary positional proteomics for screening substrates...	20526345
Q9H6S3-2-acetylation	SQSGAV...	2	acetylation-		COFRADIC		Gevaert K.	Van Damme P et al.: PC3-cells, Complementary positional proteomics for screening substrates...	20526345
Q9H6S3-2-acetylation	SQSGAV...	2	acetylation-	inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt162576
Q9H6S3-389-unknown	MSLWES...	389		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt74178
Q9H6S3-389-unknown	MSLWES...	389		inferred from isoform by sequence similarity	unknown	TopFIND		inferred from TNt106732

C-termini

Sequence	Position	Evidence type	Method	Source (database)	Evidence name
...SDGVAK	25	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000437085
...SDGVAK	25	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt153732
...IRKLVQ	79	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432923
...IRKLVQ	79	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154111
...VQLSSK	83	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000433223
...VQLSSK	83	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154165
...EMLLQV	95	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000432765
...EMLLQV	95	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154315
...LRLLDI	105	inferred from electronic annotation	unknown	Ensembl	inferred from ensembl protein ENSP00000435128
...LRLLDI	105	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt154432
...RGEDS	715	inferred from electronic annotation	electronic annotation	UniProtKB	inferred from uniprot
...RGEDS	715	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69796
...RGEDS	715	inferred from isoform by sequence similarity	unknown	TopFIND	inferred from TCt69797

Cleavages

Protease	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)

Substrates

Substrate	Position	Sequence	Evidence type	Method	Source (database)	Source (Lab)	Evidence name	Publications (PMIDs)